ES2193568T3 - Procedimiento de preparacion de lactamas n-derivadas enriquecidas enantiomericamente. - Google Patents

Procedimiento de preparacion de lactamas n-derivadas enriquecidas enantiomericamente.

Info

Publication number
ES2193568T3
ES2193568T3 ES98951307T ES98951307T ES2193568T3 ES 2193568 T3 ES2193568 T3 ES 2193568T3 ES 98951307 T ES98951307 T ES 98951307T ES 98951307 T ES98951307 T ES 98951307T ES 2193568 T3 ES2193568 T3 ES 2193568T3
Authority
ES
Spain
Prior art keywords
enriquecidas
enantiomericamente
lactames
derived
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98951307T
Other languages
English (en)
Inventor
Michael John Dawson
Mahmound Mahmoudian
Christopher John Wallis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2193568T3 publication Critical patent/ES2193568T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento de producción de productos intermedios sensiblemente puros desde el punto de vista de los enantiómeros, que son representados por la fórmula (IV) en la que P es un grupo de activación y de protección. Se obtienen estos productos intermedios a partir de sus compuestos racémicos tratando la mezcla mediante una enzima acilasa procedente de Bacillus sp sp).
ES98951307T 1997-08-22 1998-08-20 Procedimiento de preparacion de lactamas n-derivadas enriquecidas enantiomericamente. Expired - Lifetime ES2193568T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9717928.7A GB9717928D0 (en) 1997-08-22 1997-08-22 Process for the enatioselective hydrolysis of n-derivatised lactams

Publications (1)

Publication Number Publication Date
ES2193568T3 true ES2193568T3 (es) 2003-11-01

Family

ID=10817952

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98951307T Expired - Lifetime ES2193568T3 (es) 1997-08-22 1998-08-20 Procedimiento de preparacion de lactamas n-derivadas enriquecidas enantiomericamente.

Country Status (35)

Country Link
US (1) US6340587B1 (es)
EP (1) EP1003903B1 (es)
JP (1) JP3565868B2 (es)
KR (1) KR100479894B1 (es)
CN (1) CN1133749C (es)
AP (1) AP1104A (es)
AR (1) AR016395A1 (es)
AT (1) ATE233323T1 (es)
AU (1) AU738897B2 (es)
BR (1) BR9810472B1 (es)
CA (1) CA2295017A1 (es)
CZ (1) CZ294302B6 (es)
DE (1) DE69811677T2 (es)
DK (1) DK1003903T3 (es)
EA (1) EA001964B1 (es)
EE (1) EE03934B1 (es)
ES (1) ES2193568T3 (es)
GB (1) GB9717928D0 (es)
HK (1) HK1025796A1 (es)
HR (1) HRP990408B1 (es)
HU (1) HU222657B1 (es)
ID (1) ID25830A (es)
IL (1) IL133541A (es)
IN (1) IN183908B (es)
IS (1) IS2201B (es)
NO (1) NO320081B1 (es)
NZ (1) NZ501880A (es)
PL (1) PL191108B1 (es)
PT (1) PT1003903E (es)
RS (1) RS49542B (es)
SI (1) SI1003903T1 (es)
SK (1) SK282782B6 (es)
TR (1) TR199903210T2 (es)
TW (1) TW589301B (es)
WO (1) WO1999010519A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1095160T3 (da) 1998-07-09 2004-05-17 Lonza Ag Fremgangsmåde til fremstilling af (1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivater
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
US6780635B2 (en) * 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1348765B1 (en) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
HUE026849T2 (en) 2010-01-27 2016-08-29 Viiv Healthcare Company Corp Service Company Therapeutic combination containing dolutegravir, abacavir and lamivudine
CN103695495B (zh) * 2014-01-14 2014-08-27 营口三征新科技化工有限公司 一种制备(1R,4s)-(-)-2-氮杂双环[2,2,1]庚-5-烯-3-酮的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2067693T3 (es) * 1989-10-16 1995-04-01 Chiroscience Ltd Azabicicloheptanona quiral y un procedimiento para su preparacion.
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén

Also Published As

Publication number Publication date
EA001964B1 (ru) 2001-10-22
AP9901721A0 (en) 1999-12-31
CA2295017A1 (en) 1999-03-04
TR199903210T2 (xx) 2000-07-21
AU738897B2 (en) 2001-09-27
DE69811677D1 (de) 2003-04-03
HUP0002661A3 (en) 2001-12-28
BR9810472B1 (pt) 2011-01-11
KR20010014078A (ko) 2001-02-26
DE69811677T2 (de) 2003-10-16
EE03934B1 (et) 2002-12-16
CN1133749C (zh) 2004-01-07
AP1104A (en) 2002-09-04
BR9810472A (pt) 2000-09-19
SK184499A3 (en) 2000-09-12
ID25830A (id) 2000-11-09
PL191108B1 (pl) 2006-03-31
EE200000075A (et) 2000-10-16
HRP990408A2 (en) 2000-04-30
CN1261405A (zh) 2000-07-26
TW589301B (en) 2004-06-01
EP1003903B1 (en) 2003-02-26
CZ471699A3 (cs) 2000-06-14
HRP990408B1 (en) 2006-05-31
NO320081B1 (no) 2005-10-17
YU69399A (sh) 2002-06-19
GB9717928D0 (en) 1997-10-29
JP2001504354A (ja) 2001-04-03
WO1999010519A1 (en) 1999-03-04
EA199901059A1 (ru) 2000-08-28
HK1025796A1 (en) 2000-11-24
EP1003903A1 (en) 2000-05-31
IN183908B (es) 2000-05-13
JP3565868B2 (ja) 2004-09-15
PL337647A1 (en) 2000-08-28
HUP0002661A2 (hu) 2000-12-28
AR016395A1 (es) 2001-07-04
HU222657B1 (hu) 2003-09-29
SI1003903T1 (en) 2003-08-31
IL133541A0 (en) 2001-04-30
DK1003903T3 (da) 2003-06-10
NO996368D0 (no) 1999-12-21
US6340587B1 (en) 2002-01-22
AU9738698A (en) 1999-03-16
NZ501880A (en) 2001-08-31
PT1003903E (pt) 2003-06-30
SK282782B6 (sk) 2002-12-03
IS5297A (is) 1999-12-14
CZ294302B6 (cs) 2004-11-10
ATE233323T1 (de) 2003-03-15
NO996368L (no) 2000-02-21
RS49542B (sr) 2007-02-05
IS2201B (is) 2007-02-15
IL133541A (en) 2003-10-31
KR100479894B1 (ko) 2005-03-30

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