BR9810472A - Processos para a preparação de (1r,4s)-2-aza-biciclo [2.2.1] hept-5-en-3-ona n-protegida substancialmente enaciomericamente pura e para a resolução enanciomérica de uma mistura racêmica de (±) 2-aza-biciclo [2.2.1] hept-5-en-3-ona n-protegida - Google Patents

Processos para a preparação de (1r,4s)-2-aza-biciclo [2.2.1] hept-5-en-3-ona n-protegida substancialmente enaciomericamente pura e para a resolução enanciomérica de uma mistura racêmica de (±) 2-aza-biciclo [2.2.1] hept-5-en-3-ona n-protegida

Info

Publication number
BR9810472A
BR9810472A BR9810472-1A BR9810472A BR9810472A BR 9810472 A BR9810472 A BR 9810472A BR 9810472 A BR9810472 A BR 9810472A BR 9810472 A BR9810472 A BR 9810472A
Authority
BR
Brazil
Prior art keywords
hept
aza
protected
pure
enaciomerically
Prior art date
Application number
BR9810472-1A
Other languages
English (en)
Other versions
BR9810472B1 (pt
Inventor
Michael John Dawson
Mahmoud Mahmoudian
Christopher John Wallis
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR9810472A publication Critical patent/BR9810472A/pt
Publication of BR9810472B1 publication Critical patent/BR9810472B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"PROCESSOS PARA A PREPARAçãO DE (1R,4S)-2-AZA-BICICLO[2.2.1]HEPT-5-EN-3-ONA N-PROTEGIDA SUBSTANCIALMENTE ENACIOMERICAMENTE PURA E PARA A RESOLUçãO ENANCIOMéRICA DE UMA MISTURA RACêMICA DE (±) 2-AZA-BICICLO[2.2.1]HEPT-5-EN-3-ONA N-PROTEGIDA" A presente invenção refere-se a um processo para a produção de intermediários de fórmula (IV): substancialmente enanciomericamente puros, na qual P é um grupo ativador ou protetor, a partir de seus racematos pelo tratamento da mistura com uma enzima acilase derivada de Bacillus sp.
BRPI9810472-1A 1997-08-22 1998-08-20 processos para a preparação de (1r,4s)-2-aza-biciclo[2.2.1]hept-5-en-3-ona n-protegida substancialmente enaciomericamente pura e para a resolução enanciomérica de uma mistura racêmica de (±) 2-aza-biciclo[2.2.1]hept-5-en-3-ona n-protegida. BR9810472B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9717928.7 1997-08-22
GBGB9717928.7A GB9717928D0 (en) 1997-08-22 1997-08-22 Process for the enatioselective hydrolysis of n-derivatised lactams
PCT/EP1998/005291 WO1999010519A1 (en) 1997-08-22 1998-08-20 Process for preparing enantiomerically enriched n-derivatised lactams

Publications (2)

Publication Number Publication Date
BR9810472A true BR9810472A (pt) 2000-09-19
BR9810472B1 BR9810472B1 (pt) 2011-01-11

Family

ID=10817952

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9810472-1A BR9810472B1 (pt) 1997-08-22 1998-08-20 processos para a preparação de (1r,4s)-2-aza-biciclo[2.2.1]hept-5-en-3-ona n-protegida substancialmente enaciomericamente pura e para a resolução enanciomérica de uma mistura racêmica de (±) 2-aza-biciclo[2.2.1]hept-5-en-3-ona n-protegida.

Country Status (35)

Country Link
US (1) US6340587B1 (pt)
EP (1) EP1003903B1 (pt)
JP (1) JP3565868B2 (pt)
KR (1) KR100479894B1 (pt)
CN (1) CN1133749C (pt)
AP (1) AP1104A (pt)
AR (1) AR016395A1 (pt)
AT (1) ATE233323T1 (pt)
AU (1) AU738897B2 (pt)
BR (1) BR9810472B1 (pt)
CA (1) CA2295017A1 (pt)
CZ (1) CZ294302B6 (pt)
DE (1) DE69811677T2 (pt)
DK (1) DK1003903T3 (pt)
EA (1) EA001964B1 (pt)
EE (1) EE03934B1 (pt)
ES (1) ES2193568T3 (pt)
GB (1) GB9717928D0 (pt)
HK (1) HK1025796A1 (pt)
HR (1) HRP990408B1 (pt)
HU (1) HU222657B1 (pt)
ID (1) ID25830A (pt)
IL (1) IL133541A (pt)
IN (1) IN183908B (pt)
IS (1) IS2201B (pt)
NO (1) NO320081B1 (pt)
NZ (1) NZ501880A (pt)
PL (1) PL191108B1 (pt)
PT (1) PT1003903E (pt)
RS (1) RS49542B (pt)
SI (1) SI1003903T1 (pt)
SK (1) SK282782B6 (pt)
TR (1) TR199903210T2 (pt)
TW (1) TW589301B (pt)
WO (1) WO1999010519A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1095160T3 (da) * 1998-07-09 2004-05-17 Lonza Ag Fremgangsmåde til fremstilling af (1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivater
DE19962543A1 (de) 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
US6780635B2 (en) * 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1348765B1 (en) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
ES2969969T3 (es) 2010-01-27 2024-05-23 Viiv Healthcare Co Combinaciones de dolutegravir y lamivudina para el tratamiento de la infección por VIH
CN103695495B (zh) * 2014-01-14 2014-08-27 营口三征新科技化工有限公司 一种制备(1R,4s)-(-)-2-氮杂双环[2,2,1]庚-5-烯-3-酮的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0424064T3 (da) * 1989-10-16 1995-06-26 Chiroscience Ltd Chirale azabicycloheptanoner og fremgangsmåde til fremstilling deraf
GB9108384D0 (en) 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
SK285228B6 (sk) * 1997-05-13 2006-09-07 Lonza Ag Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén

Also Published As

Publication number Publication date
ID25830A (id) 2000-11-09
EE03934B1 (et) 2002-12-16
JP3565868B2 (ja) 2004-09-15
GB9717928D0 (en) 1997-10-29
IS5297A (is) 1999-12-14
PL191108B1 (pl) 2006-03-31
TR199903210T2 (xx) 2000-07-21
HUP0002661A2 (hu) 2000-12-28
WO1999010519A1 (en) 1999-03-04
ATE233323T1 (de) 2003-03-15
TW589301B (en) 2004-06-01
HRP990408A2 (en) 2000-04-30
SI1003903T1 (en) 2003-08-31
KR100479894B1 (ko) 2005-03-30
DE69811677T2 (de) 2003-10-16
KR20010014078A (ko) 2001-02-26
AU9738698A (en) 1999-03-16
NO996368D0 (no) 1999-12-21
NO320081B1 (no) 2005-10-17
SK282782B6 (sk) 2002-12-03
DK1003903T3 (da) 2003-06-10
AP9901721A0 (en) 1999-12-31
CA2295017A1 (en) 1999-03-04
NO996368L (no) 2000-02-21
YU69399A (sh) 2002-06-19
HU222657B1 (hu) 2003-09-29
AU738897B2 (en) 2001-09-27
IS2201B (is) 2007-02-15
HUP0002661A3 (en) 2001-12-28
BR9810472B1 (pt) 2011-01-11
CN1133749C (zh) 2004-01-07
HRP990408B1 (en) 2006-05-31
DE69811677D1 (de) 2003-04-03
RS49542B (sr) 2007-02-05
AP1104A (en) 2002-09-04
CN1261405A (zh) 2000-07-26
EP1003903A1 (en) 2000-05-31
HK1025796A1 (en) 2000-11-24
JP2001504354A (ja) 2001-04-03
US6340587B1 (en) 2002-01-22
PT1003903E (pt) 2003-06-30
IN183908B (pt) 2000-05-13
CZ471699A3 (cs) 2000-06-14
IL133541A0 (en) 2001-04-30
EP1003903B1 (en) 2003-02-26
PL337647A1 (en) 2000-08-28
SK184499A3 (en) 2000-09-12
AR016395A1 (es) 2001-07-04
NZ501880A (en) 2001-08-31
ES2193568T3 (es) 2003-11-01
EA199901059A1 (ru) 2000-08-28
EA001964B1 (ru) 2001-10-22
CZ294302B6 (cs) 2004-11-10
EE200000075A (et) 2000-10-16
IL133541A (en) 2003-10-31

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/01/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 11.01.2021