BR0016882A - ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato - Google Patents

ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato

Info

Publication number
BR0016882A
BR0016882A BR0016882-3A BR0016882A BR0016882A BR 0016882 A BR0016882 A BR 0016882A BR 0016882 A BR0016882 A BR 0016882A BR 0016882 A BR0016882 A BR 0016882A
Authority
BR
Brazil
Prior art keywords
dimethylaminomethyl
hydroxybenzoate
phenyl
esters derived
hydroxycyclohexyl
Prior art date
Application number
BR0016882-3A
Other languages
English (en)
Inventor
Juan Huguet Clotet
Marisabel Mourelle Mancini
Elisabet De Ramon Amat
Original Assignee
Vita Invest Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest Sa filed Critical Vita Invest Sa
Publication of BR0016882A publication Critical patent/BR0016882A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"éSTERES DERIVADOS DE (RR,SS)-3-(2-DIMETILAMINOMETIL-1-HIDROXICICLOEXIL)FENIL 2-HIDROXIBENZOATO". Novos ésteres derivados de (RR,SS)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato, análogos a Tramadol, um processo para obtê-los e o uso destes compostos para a produção de um medicamento com propriedades analgésicas. Estes novos produtos de fórmula geral (I) apresentam uma atividade analgésica maior que a de tramadol.
BR0016882-3A 1999-12-30 2000-12-26 ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato BR0016882A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
PCT/ES2000/000486 WO2001049650A1 (es) 1999-12-30 2000-12-26 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil)fenilo

Publications (1)

Publication Number Publication Date
BR0016882A true BR0016882A (pt) 2002-11-05

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016882-3A BR0016882A (pt) 1999-12-30 2000-12-26 ésteres derivados de (rr,ss)-3-(2-dimetilaminometil-1-hidroxicicloexil)fenil 2-hidroxibenzoato

Country Status (30)

Country Link
US (1) US6894076B2 (pt)
EP (1) EP1251120B1 (pt)
JP (1) JP2003519208A (pt)
KR (1) KR20020063281A (pt)
CN (1) CN1414946A (pt)
AP (1) AP1234A (pt)
AT (1) ATE284380T1 (pt)
AU (1) AU775918B2 (pt)
BG (1) BG106883A (pt)
BR (1) BR0016882A (pt)
CA (1) CA2395976A1 (pt)
CZ (1) CZ20022189A3 (pt)
DE (1) DE60016631D1 (pt)
EA (1) EA004770B1 (pt)
EE (1) EE200200365A (pt)
ES (1) ES2160534B1 (pt)
HR (1) HRP20020559A2 (pt)
HU (1) HUP0204147A3 (pt)
IL (1) IL150392A0 (pt)
IS (1) IS6440A (pt)
MA (1) MA26862A1 (pt)
MX (1) MXPA02006514A (pt)
NO (1) NO20023098D0 (pt)
NZ (1) NZ520263A (pt)
OA (1) OA12132A (pt)
PL (1) PL356056A1 (pt)
SK (1) SK9252002A3 (pt)
WO (1) WO2001049650A1 (pt)
YU (1) YU50902A (pt)
ZA (1) ZA200205193B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
WO2009092601A1 (en) 2008-01-25 2009-07-30 Grünenthal GmbH Pharmaceutical dosage form
MX2010012039A (es) 2008-05-09 2010-11-30 Gruenenthal Gmbh Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio.
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
RU2567723C2 (ru) 2009-07-22 2015-11-10 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
PE20131126A1 (es) 2010-09-02 2013-10-21 Gruenenthal Chemie Forma de dosificacion resistente a alteracion que comprende un polimero anionico
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
DK2736497T3 (da) 2011-07-29 2017-11-13 Gruenenthal Gmbh Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel.
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
WO2013156453A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096438A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
KR20170139158A (ko) 2015-04-24 2017-12-18 그뤼넨탈 게엠베하 즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
CN107001347B (zh) 2015-10-15 2019-09-24 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
EE200200365A (et) 2003-10-15
IS6440A (is) 2002-06-25
HUP0204147A3 (en) 2003-10-28
NO20023098L (no) 2002-06-26
ZA200205193B (en) 2003-06-27
JP2003519208A (ja) 2003-06-17
CZ20022189A3 (cs) 2003-03-12
MXPA02006514A (es) 2004-07-30
MA26862A1 (fr) 2004-12-20
US6894076B2 (en) 2005-05-17
AP1234A (en) 2003-12-28
DE60016631D1 (de) 2005-01-13
HRP20020559A2 (en) 2004-02-29
YU50902A (sh) 2006-01-16
NZ520263A (en) 2004-07-30
US20030100598A1 (en) 2003-05-29
AP2002002571A0 (en) 2002-09-30
EA004770B1 (ru) 2004-08-26
ES2160534B1 (es) 2002-04-16
ES2160534A1 (es) 2001-11-01
EP1251120A1 (en) 2002-10-23
IL150392A0 (en) 2002-12-01
AU2012601A (en) 2001-07-16
WO2001049650A1 (es) 2001-07-12
CN1414946A (zh) 2003-04-30
AU775918B2 (en) 2004-08-19
EA200200614A1 (ru) 2002-12-26
PL356056A1 (en) 2004-06-14
HUP0204147A2 (hu) 2003-04-28
BG106883A (en) 2003-05-30
CA2395976A1 (en) 2001-07-12
ATE284380T1 (de) 2004-12-15
NO20023098D0 (no) 2002-06-26
EP1251120B1 (en) 2004-12-08
SK9252002A3 (en) 2003-04-01
OA12132A (en) 2006-05-05
KR20020063281A (ko) 2002-08-01

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: LABORATORIOS VITA, S.A. (ES)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.