ATE295728T1 - Herstellung von 3-fluoroxindolderivaten - Google Patents
Herstellung von 3-fluoroxindolderivatenInfo
- Publication number
- ATE295728T1 ATE295728T1 AT97909835T AT97909835T ATE295728T1 AT E295728 T1 ATE295728 T1 AT E295728T1 AT 97909835 T AT97909835 T AT 97909835T AT 97909835 T AT97909835 T AT 97909835T AT E295728 T1 ATE295728 T1 AT E295728T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- fluoroxindole
- production
- enantiomer
- similar
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2829696P | 1996-10-11 | 1996-10-11 | |
US2754396P | 1996-10-15 | 1996-10-15 | |
US4821897P | 1997-05-30 | 1997-05-30 | |
PCT/US1997/015323 WO1998016222A1 (en) | 1996-10-11 | 1997-10-07 | Preparation of 3-fluoro oxindole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE295728T1 true ATE295728T1 (de) | 2005-06-15 |
Family
ID=27363036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97909835T ATE295728T1 (de) | 1996-10-11 | 1997-10-07 | Herstellung von 3-fluoroxindolderivaten |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0946173B1 (de) |
JP (1) | JP4121153B2 (de) |
KR (1) | KR100506540B1 (de) |
AT (1) | ATE295728T1 (de) |
AU (1) | AU728455B2 (de) |
CA (1) | CA2267947C (de) |
DE (1) | DE69733316T2 (de) |
ES (1) | ES2241041T3 (de) |
IL (1) | IL129012A (de) |
TW (1) | TW457233B (de) |
WO (1) | WO1998016222A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03000032A (es) * | 2000-06-29 | 2003-08-19 | Neurosearch As | Uso de derivados de oxindol 3-sustituidos como moduladores de los canales de potasio kcnq. |
CN110240558B (zh) * | 2019-07-10 | 2022-05-27 | 上海华理生物医药股份有限公司 | 一种Flindokalner消旋体的新合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972894A (en) * | 1973-04-27 | 1976-08-03 | The Ohio State University Research Foundation | Synthesis of oxindoles from anilines and β-thio carboxylic esters or amides |
DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
GB8621040D0 (en) * | 1986-08-30 | 1986-10-08 | Smith Kline French Lab | Process |
-
1997
- 1997-10-03 TW TW086114472A patent/TW457233B/zh active
- 1997-10-07 EP EP97909835A patent/EP0946173B1/de not_active Expired - Lifetime
- 1997-10-07 KR KR10-2004-7021189A patent/KR100506540B1/ko not_active IP Right Cessation
- 1997-10-07 JP JP51832598A patent/JP4121153B2/ja not_active Expired - Fee Related
- 1997-10-07 IL IL12901297A patent/IL129012A/xx not_active IP Right Cessation
- 1997-10-07 AU AU47343/97A patent/AU728455B2/en not_active Ceased
- 1997-10-07 WO PCT/US1997/015323 patent/WO1998016222A1/en active IP Right Grant
- 1997-10-07 CA CA002267947A patent/CA2267947C/en not_active Expired - Fee Related
- 1997-10-07 DE DE69733316T patent/DE69733316T2/de not_active Expired - Fee Related
- 1997-10-07 AT AT97909835T patent/ATE295728T1/de not_active IP Right Cessation
- 1997-10-07 ES ES97909835T patent/ES2241041T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU4734397A (en) | 1998-05-11 |
WO1998016222A1 (en) | 1998-04-23 |
IL129012A (en) | 2003-02-12 |
TW457233B (en) | 2001-10-01 |
CA2267947A1 (en) | 1998-04-23 |
EP0946173B1 (de) | 2005-05-18 |
EP0946173A1 (de) | 1999-10-06 |
CA2267947C (en) | 2009-04-07 |
JP2001524935A (ja) | 2001-12-04 |
EP0946173A4 (de) | 2000-01-05 |
JP4121153B2 (ja) | 2008-07-23 |
AU728455B2 (en) | 2001-01-11 |
DE69733316D1 (de) | 2005-06-23 |
ES2241041T3 (es) | 2005-10-16 |
DE69733316T2 (de) | 2006-01-26 |
KR100506540B1 (ko) | 2005-08-05 |
KR20050013161A (ko) | 2005-02-02 |
IL129012A0 (en) | 2000-02-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1023987A1 (en) | Sulphinic acid derivatives, method for producing, and their use | |
FI961809A (fi) | Uudet (R)-5-karbamoyyli-8-fluori-3-N,N-disubstituoitu-amino 3,4-dihydro-2H-1-bentsopyraanit | |
DE69010139D1 (de) | Haarkräftigungsmittel. | |
MX9203338A (es) | Nuevos derivados del oxico a_nor-esteroide-3-carboxilico. | |
DK0696281T3 (da) | Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater | |
ES485621A1 (es) | Un procedimiento para la preparacion de derivados de diben- zopirano | |
AU4938985A (en) | Polypeptide | |
DK0772604T3 (da) | Trialzolforbindelser og deres anvendelse som dopamin-D3-ligander | |
MY117090A (en) | Substituted benzamidines, their preparation and their use as pharmaceutical compounds | |
IL113011A (en) | R-mandelic acid salt of (2s,3s)-3- (2-methoxybenzylamino)-2- phenylpiperidine | |
UA26403A (uk) | Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція | |
ATE295728T1 (de) | Herstellung von 3-fluoroxindolderivaten | |
EA199600007A2 (ru) | Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза | |
IT1237529B (it) | Composti spiro-indolino-ossazine con caratteristiche fotocromatiche e fotosensibilizzatrici e procedimento per la loro preparazione | |
HUP0000783A2 (hu) | N-(piridinil-amino)-izoindolinok és származékaik, eljárás előállításukra, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
ATE207482T1 (de) | Verfahren zur herstellung von n2-arylsulfonyl-l- argininamiden | |
HUP0001058A2 (hu) | 5-Hidroxi-metil-2-amino-tetralinok mint szív-érrendszerre ható szerek, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
NO972605L (no) | Ny fremgangsmåte for fremstilling av ranitidin | |
EP0158283A3 (de) | Substituierte 1-Aminoalkylamino-4-aryloxypiperidine, Verfahren zu ihrer Herstellung, ihre Zwischenprodukte und ihre Verwendung als Medikamente | |
AU573062B2 (en) | Dihydrodithiazine derivatives | |
ATE168683T1 (de) | Substituierte iminoacetonitrile mit myokardprotektiver wirkung | |
AU7453487A (en) | Cis and trans stilbenes | |
MX9605668A (es) | Sal de estilbazolio, su preparacion y uso. | |
ES8606375A1 (es) | Un procedimiento para preparar un derivado de aminoprpilaminobleomicina | |
ES8707945A3 (es) | Un procedimiento para la preparacion de una sal de adicion de acido de 2-(7-indeniloximetil) morfolina. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0946173 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |