YU50902A - Novi estri izvedeni iz (rr,ss)-3-(2-dimetilaminometil-1-hidroksicikloheksil)fenil 2-hidroksibenzoata - Google Patents

Novi estri izvedeni iz (rr,ss)-3-(2-dimetilaminometil-1-hidroksicikloheksil)fenil 2-hidroksibenzoata

Info

Publication number
YU50902A
YU50902A YU50902A YUP50902A YU50902A YU 50902 A YU50902 A YU 50902A YU 50902 A YU50902 A YU 50902A YU P50902 A YUP50902 A YU P50902A YU 50902 A YU50902 A YU 50902A
Authority
YU
Yugoslavia
Prior art keywords
dimethylaminomethyl
hydroxybenzoate
phenyl
esters derived
hydroxycyclohexyl
Prior art date
Application number
YU50902A
Other languages
English (en)
Inventor
Clotet Juan Huguet
Mancini Marisabel Mourelle
Amat Elisabet De Ramon
Original Assignee
Laboratorios Vita S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vita S.A. filed Critical Laboratorios Vita S.A.
Publication of YU50902A publication Critical patent/YU50902A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Novi estri izvedeni od (RR,SS)-3-(2-dimetilaminometil-1-hidroksicikloheksil)fenil 2-hidroksibenzoata, analogni Tramadol-u, postupak za njihovo dobijanje i upotreba ovih jedinjenja za proizvodnju leka sa analgetičkim svojstvima. Ovi novi proizvodi opšte formule (I) pokazuju jače analgetičko dejstvo od tramadola.[The invention concerns novel esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclocyclohexyl)phenyl, Tramadol analogs, method for obtaining said esters and to the utilization of said compounds for the production of a medicament having analgesic properties. These novel products of general formula (I) show a higher analgesic activity than tramadol.
YU50902A 1999-12-30 2000-12-26 Novi estri izvedeni iz (rr,ss)-3-(2-dimetilaminometil-1-hidroksicikloheksil)fenil 2-hidroksibenzoata YU50902A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000060A ES2160534B1 (es) 1999-12-30 1999-12-30 Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.

Publications (1)

Publication Number Publication Date
YU50902A true YU50902A (sh) 2006-01-16

Family

ID=8491916

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50902A YU50902A (sh) 1999-12-30 2000-12-26 Novi estri izvedeni iz (rr,ss)-3-(2-dimetilaminometil-1-hidroksicikloheksil)fenil 2-hidroksibenzoata

Country Status (30)

Country Link
US (1) US6894076B2 (sh)
EP (1) EP1251120B1 (sh)
JP (1) JP2003519208A (sh)
KR (1) KR20020063281A (sh)
CN (1) CN1414946A (sh)
AP (1) AP1234A (sh)
AT (1) ATE284380T1 (sh)
AU (1) AU775918B2 (sh)
BG (1) BG106883A (sh)
BR (1) BR0016882A (sh)
CA (1) CA2395976A1 (sh)
CZ (1) CZ20022189A3 (sh)
DE (1) DE60016631D1 (sh)
EA (1) EA004770B1 (sh)
EE (1) EE200200365A (sh)
ES (1) ES2160534B1 (sh)
HR (1) HRP20020559A2 (sh)
HU (1) HUP0204147A3 (sh)
IL (1) IL150392A0 (sh)
IS (1) IS6440A (sh)
MA (1) MA26862A1 (sh)
MX (1) MXPA02006514A (sh)
NO (1) NO20023098D0 (sh)
NZ (1) NZ520263A (sh)
OA (1) OA12132A (sh)
PL (1) PL356056A1 (sh)
SK (1) SK9252002A3 (sh)
WO (1) WO2001049650A1 (sh)
YU (1) YU50902A (sh)
ZA (1) ZA200205193B (sh)

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US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
EP2249811A1 (en) 2008-01-25 2010-11-17 Grünenthal GmbH Pharmaceutical dosage form
EP2273983B1 (en) 2008-05-09 2016-07-20 Grünenthal GmbH Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
US8058469B2 (en) * 2008-11-03 2011-11-15 Sabic Innovative Plastics Ip B.V. Method for making carbamates, ureas and isocyanates
PL2456427T3 (pl) 2009-07-22 2015-07-31 Gruenenthal Gmbh Wytłaczana na gorąco postać dawki o kontrolowanym uwalnianiu
PL2456424T3 (pl) 2009-07-22 2013-12-31 Gruenenthal Gmbh Stabilizowana przed utlenianiem odporna na naruszenie postać dawkowania
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
AU2011297901B2 (en) 2010-09-02 2014-07-31 Grunenthal Gmbh Tamper resistant dosage form comprising inorganic salt
MX2013002293A (es) 2010-09-02 2013-05-09 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico.
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
US20130028972A1 (en) 2011-07-29 2013-01-31 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
PE20141638A1 (es) 2011-07-29 2014-11-22 Gruenenthal Chemie Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
EA201401139A1 (ru) 2012-04-18 2015-03-31 Грюненталь Гмбх Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX2015016254A (es) 2013-05-29 2016-04-20 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
WO2016170097A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
DK3354649T3 (da) 2015-10-15 2020-02-24 Jiangsu Hengrui Medicine Co Oxaspiroderivat, fremstillingsmetode derfor og anvendelser deraf i lægemidler

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DE1199764B (de) * 1963-04-02 1965-09-02 Gruenenthal Chemie Verfahren zur Herstellung von basisch substituierten Phenolaethern
DE1518663A1 (de) 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US3562589A (en) * 1968-09-09 1971-02-09 Ite Imperial Corp Electrically resetting undervoltage trip for circuit breakers
US5470885A (en) * 1993-09-29 1995-11-28 The Research Foundation Of The State University Of New York Fluorocarbons as anti-inflammatory agents
DE19525137C2 (de) 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
ES2141688B1 (es) * 1998-11-06 2001-02-01 Vita Invest Sa Nuevos esteres derivados de compuestos fenil-ciclohexil sustituidos.
GB9924604D0 (en) * 1999-10-18 1999-12-22 European Molecular Biology Lab Embl Genetic switch

Also Published As

Publication number Publication date
MA26862A1 (fr) 2004-12-20
AP1234A (en) 2003-12-28
MXPA02006514A (es) 2004-07-30
HUP0204147A3 (en) 2003-10-28
NO20023098L (no) 2002-06-26
EA200200614A1 (ru) 2002-12-26
BG106883A (en) 2003-05-30
AU2012601A (en) 2001-07-16
CZ20022189A3 (cs) 2003-03-12
JP2003519208A (ja) 2003-06-17
US6894076B2 (en) 2005-05-17
NO20023098D0 (no) 2002-06-26
ATE284380T1 (de) 2004-12-15
WO2001049650A1 (es) 2001-07-12
IL150392A0 (en) 2002-12-01
HRP20020559A2 (en) 2004-02-29
PL356056A1 (en) 2004-06-14
ES2160534A1 (es) 2001-11-01
EE200200365A (et) 2003-10-15
NZ520263A (en) 2004-07-30
SK9252002A3 (en) 2003-04-01
BR0016882A (pt) 2002-11-05
CA2395976A1 (en) 2001-07-12
OA12132A (en) 2006-05-05
IS6440A (is) 2002-06-25
KR20020063281A (ko) 2002-08-01
EA004770B1 (ru) 2004-08-26
DE60016631D1 (de) 2005-01-13
ZA200205193B (en) 2003-06-27
EP1251120B1 (en) 2004-12-08
AU775918B2 (en) 2004-08-19
US20030100598A1 (en) 2003-05-29
CN1414946A (zh) 2003-04-30
AP2002002571A0 (en) 2002-09-30
ES2160534B1 (es) 2002-04-16
HUP0204147A2 (hu) 2003-04-28
EP1251120A1 (en) 2002-10-23

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