MX9304057A - Procedimiento enzimatico para resolver mezclas ra cemicas de delta-valerolactona - Google Patents
Procedimiento enzimatico para resolver mezclas ra cemicas de delta-valerolactonaInfo
- Publication number
- MX9304057A MX9304057A MX9304057A MX9304057A MX9304057A MX 9304057 A MX9304057 A MX 9304057A MX 9304057 A MX9304057 A MX 9304057A MX 9304057 A MX9304057 A MX 9304057A MX 9304057 A MX9304057 A MX 9304057A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- delta
- mixtures
- enantiomer
- cemic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 title 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- WMHRYMDGHQIARA-UHFFFAOYSA-N 4-hydroxyoxan-2-one Chemical class OC1CCOC(=O)C1 WMHRYMDGHQIARA-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000012374 esterification agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
El campo de aplicación del invento es la resolución de mezclas racémicas de delta-valerolactonas, por medios enzimáticos. El problema planteado era obtener fácilmente y con buen rendimiento, determinados enantiómeros de oxetanonas que presentan buenas propiedades farmacéuticas.Los métodos conocidos son engorrosos y de poco rendimiento. Este problema se resuelve, según el invento, resolviendo en una etapa temprana del proceso de obtención de dichas oxetanonas, una mezcla racémica de beta-hidroxi-delta valerolactonas, de fórmula general I en la que R es hidrógeno o asilo y R1 y R2 representan, independientemente, hidrógeno, alquilo, alcoxialquilo o arilalquilo eventualmente sustituido, empleando una hidrolasa en presencia de un diluyente y, en caso de que R sea hidrógeno, de un agente de esterificación, y la mezcla obtenida, de un enantiómero para el que R es hidrógeno y de otro enantiómero para el que R es hidrógeno y de otro enantiómero para el que R es asilo, se separa del modo usual en sus componentes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0137492A AT398579B (de) | 1992-07-06 | 1992-07-06 | Enzymatisches verfahren zur trennung racemischer gemische von delta-valerolactonen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9304057A true MX9304057A (es) | 1994-02-28 |
Family
ID=3512505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9304057A MX9304057A (es) | 1992-07-06 | 1993-07-06 | Procedimiento enzimatico para resolver mezclas ra cemicas de delta-valerolactona |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5412110A (es) |
| EP (1) | EP0578016A3 (es) |
| JP (1) | JPH06153988A (es) |
| KR (1) | KR940005806A (es) |
| CN (1) | CN1082113A (es) |
| AT (1) | AT398579B (es) |
| AU (1) | AU670088B2 (es) |
| BR (1) | BR9302763A (es) |
| CA (1) | CA2096597A1 (es) |
| CZ (1) | CZ133293A3 (es) |
| FI (1) | FI933079A (es) |
| HR (1) | HRP931019A2 (es) |
| HU (1) | HUT67439A (es) |
| IL (1) | IL105720A (es) |
| MX (1) | MX9304057A (es) |
| MY (1) | MY109188A (es) |
| NO (1) | NO932030L (es) |
| NZ (1) | NZ247636A (es) |
| SI (1) | SI9300361A (es) |
| SK (1) | SK69793A3 (es) |
| TR (1) | TR27224A (es) |
| YU (1) | YU40493A (es) |
| ZA (1) | ZA933682B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020500A (en) * | 1995-08-22 | 2000-02-01 | The Lubrizol Corporation | Hydroxy-substituted monolactones useful as intermediates for preparing lubricating oil and fuel additives |
| KR100238290B1 (ko) * | 1997-06-16 | 2000-01-15 | 윤종용 | 테이프 레코더의 릴디스크 제동장치 |
| JPH11165762A (ja) * | 1997-12-01 | 1999-06-22 | Lintec Corp | チップ体搬送用カバーテープおよび封止構造体 |
| EP1651627A2 (en) * | 2003-07-15 | 2006-05-03 | Ranbaxy Laboratories Limited | Process for preparation of oxetan-2-ones |
| KR101035526B1 (ko) * | 2004-04-26 | 2011-05-23 | 덴끼 가가꾸 고교 가부시키가이샤 | 커버 테이프 및 전자 부품 포장용 캐리어 테이프 시스템 |
| KR101145344B1 (ko) * | 2010-04-09 | 2012-05-14 | 박진성 | 전자 부품 이송용 커버 테이프 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE87036T1 (de) * | 1986-11-28 | 1993-04-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von carbonsaeureestern. |
| DE3743824C2 (de) * | 1987-12-23 | 1997-03-06 | Hoechst Ag | Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung |
| JP2542941B2 (ja) * | 1990-02-02 | 1996-10-09 | チッソ株式会社 | 光学活性ヒドロキシラクトン類の製造方法 |
| DE4005150A1 (de) * | 1990-02-17 | 1991-08-22 | Hoechst Ag | Verfahren zur enzymatischen racematspaltung von pantolacton |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| CA2118795A1 (en) * | 1991-09-20 | 1993-04-01 | John Crosby | Pyranones |
| WO1993006235A1 (en) * | 1991-09-20 | 1993-04-01 | Zeneca Limited | Process for the preparation of enantiomerically pure 4-hydroxytetrahydro-2-pyranone derivatives |
| DE4225817A1 (de) * | 1992-08-05 | 1994-02-10 | Chemie Linz Deutschland | Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen |
-
1992
- 1992-07-06 AT AT0137492A patent/AT398579B/de not_active IP Right Cessation
- 1992-08-28 US US07/936,782 patent/US5412110A/en not_active Expired - Fee Related
-
1993
- 1993-05-17 NZ NZ247636A patent/NZ247636A/en unknown
- 1993-05-17 IL IL105720A patent/IL105720A/en not_active IP Right Cessation
- 1993-05-19 CA CA002096597A patent/CA2096597A1/en not_active Abandoned
- 1993-05-26 ZA ZA933682A patent/ZA933682B/xx unknown
- 1993-06-03 NO NO932030A patent/NO932030L/no unknown
- 1993-06-10 YU YU40493A patent/YU40493A/sh unknown
- 1993-06-16 EP EP93109597A patent/EP0578016A3/xx not_active Withdrawn
- 1993-06-17 AU AU41325/93A patent/AU670088B2/en not_active Ceased
- 1993-06-30 TR TR00587/93A patent/TR27224A/xx unknown
- 1993-07-01 SK SK697-93A patent/SK69793A3/sk unknown
- 1993-07-01 CZ CZ931332A patent/CZ133293A3/cs unknown
- 1993-07-05 HU HU9301956A patent/HUT67439A/hu unknown
- 1993-07-05 CN CN93108080A patent/CN1082113A/zh active Pending
- 1993-07-05 HR HRA1374/92A patent/HRP931019A2/xx not_active Application Discontinuation
- 1993-07-05 BR BR9302763A patent/BR9302763A/pt not_active Application Discontinuation
- 1993-07-05 KR KR1019930012517A patent/KR940005806A/ko not_active Application Discontinuation
- 1993-07-05 FI FI933079A patent/FI933079A/fi not_active Application Discontinuation
- 1993-07-05 MY MYPI93001306A patent/MY109188A/en unknown
- 1993-07-05 JP JP5165567A patent/JPH06153988A/ja not_active Withdrawn
- 1993-07-06 MX MX9304057A patent/MX9304057A/es unknown
- 1993-07-06 SI SI9300361A patent/SI9300361A/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO932030L (no) | 1994-01-07 |
| MY109188A (en) | 1996-12-31 |
| SI9300361A (en) | 1994-03-31 |
| US5412110A (en) | 1995-05-02 |
| AU670088B2 (en) | 1996-07-04 |
| TR27224A (tr) | 1994-12-20 |
| FI933079A0 (fi) | 1993-07-05 |
| EP0578016A3 (en) | 1995-03-01 |
| ZA933682B (en) | 1993-12-21 |
| HRP931019A2 (en) | 1997-04-30 |
| CZ133293A3 (en) | 1994-02-16 |
| BR9302763A (pt) | 1994-02-16 |
| KR940005806A (ko) | 1994-03-22 |
| JPH06153988A (ja) | 1994-06-03 |
| CA2096597A1 (en) | 1994-01-07 |
| HUT67439A (en) | 1995-04-28 |
| NO932030D0 (no) | 1993-06-03 |
| HU9301956D0 (en) | 1993-10-28 |
| ATA137492A (de) | 1994-05-15 |
| YU40493A (sh) | 1996-07-24 |
| IL105720A0 (en) | 1993-09-22 |
| IL105720A (en) | 1998-01-04 |
| FI933079A (fi) | 1994-01-07 |
| NZ247636A (en) | 1995-04-27 |
| SK69793A3 (en) | 1994-05-11 |
| AT398579B (de) | 1994-12-27 |
| EP0578016A2 (de) | 1994-01-12 |
| CN1082113A (zh) | 1994-02-16 |
| AU4132593A (en) | 1994-01-13 |
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