MX2021014111A - Proceso para la preparacion de epimeros de fosforamidita de galnac. - Google Patents
Proceso para la preparacion de epimeros de fosforamidita de galnac.Info
- Publication number
- MX2021014111A MX2021014111A MX2021014111A MX2021014111A MX2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A MX 2021014111 A MX2021014111 A MX 2021014111A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- epimers
- galnac
- galnac phosphoramidite
- phosphoramidite
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención comprende un proceso para la preparación de un epímero de fosforamidita de GalNAc de fórmula I, en donde R1 es un grupo protector de hidroxilo, n es un número entero de 0 a 10 y m es un número entero de 0 a 20, enantiómeros y/o isómeros ópticos correspondientes del mismo y el uso del proceso para la preparación de conjugados de oligonucleótidos de complejo GalNAc.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19175309 | 2019-05-20 | ||
PCT/EP2020/063749 WO2020234208A1 (en) | 2019-05-20 | 2020-05-18 | Process for the preparation of galnac phosphoramidite epimers |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021014111A true MX2021014111A (es) | 2021-12-10 |
Family
ID=66625050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021014111A MX2021014111A (es) | 2019-05-20 | 2020-05-18 | Proceso para la preparacion de epimeros de fosforamidita de galnac. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220259248A1 (es) |
EP (1) | EP3972984A1 (es) |
JP (1) | JP2022533220A (es) |
KR (1) | KR20220010496A (es) |
CN (1) | CN113840828B (es) |
AR (1) | AR118949A1 (es) |
AU (1) | AU2020278797A1 (es) |
CA (1) | CA3134494A1 (es) |
IL (1) | IL288116A (es) |
MX (1) | MX2021014111A (es) |
SG (1) | SG11202110680PA (es) |
TW (1) | TW202110483A (es) |
WO (1) | WO2020234208A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117756866A (zh) * | 2022-01-30 | 2024-03-26 | 大睿生物医药科技(上海)有限公司 | 含有n-乙酰半乳糖胺的靶向配体 |
WO2024075760A1 (ja) * | 2022-10-05 | 2024-04-11 | 第一三共株式会社 | 2分岐型n-アセチル-d-ガラクトサミン構造を有する化合物の製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2982825C (en) * | 2015-08-06 | 2023-10-17 | F. Hoffmann-La Roche Ag | Processes for the preparation of galnac acid derivatives |
WO2017084987A1 (en) | 2015-11-16 | 2017-05-26 | F. Hoffmann-La Roche Ag | GalNAc CLUSTER PHOSPHORAMIDITE |
WO2018215049A1 (en) * | 2017-05-23 | 2018-11-29 | F. Hoffmann-La Roche Ag | Process for galnac oligonucleotide conjugates |
-
2020
- 2020-05-18 CN CN202080037148.6A patent/CN113840828B/zh active Active
- 2020-05-18 WO PCT/EP2020/063749 patent/WO2020234208A1/en unknown
- 2020-05-18 SG SG11202110680PA patent/SG11202110680PA/en unknown
- 2020-05-18 CA CA3134494A patent/CA3134494A1/en active Pending
- 2020-05-18 US US17/612,900 patent/US20220259248A1/en active Pending
- 2020-05-18 JP JP2021569002A patent/JP2022533220A/ja active Pending
- 2020-05-18 KR KR1020217037546A patent/KR20220010496A/ko active Search and Examination
- 2020-05-18 MX MX2021014111A patent/MX2021014111A/es unknown
- 2020-05-18 AU AU2020278797A patent/AU2020278797A1/en active Pending
- 2020-05-18 AR ARP200101400A patent/AR118949A1/es unknown
- 2020-05-18 EP EP20725557.1A patent/EP3972984A1/en active Pending
- 2020-05-19 TW TW109116480A patent/TW202110483A/zh unknown
-
2021
- 2021-11-15 IL IL288116A patent/IL288116A/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11202110680PA (en) | 2021-10-28 |
TW202110483A (zh) | 2021-03-16 |
WO2020234208A1 (en) | 2020-11-26 |
US20220259248A1 (en) | 2022-08-18 |
KR20220010496A (ko) | 2022-01-25 |
JP2022533220A (ja) | 2022-07-21 |
CA3134494A1 (en) | 2020-11-26 |
EP3972984A1 (en) | 2022-03-30 |
IL288116A (en) | 2022-01-01 |
CN113840828A (zh) | 2021-12-24 |
CN113840828B (zh) | 2024-01-16 |
AU2020278797A1 (en) | 2021-10-07 |
AR118949A1 (es) | 2021-11-10 |
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