ES2145223T3 - Procedimiento de produccion de tiofosfolipidos del tipo eter. - Google Patents

Procedimiento de produccion de tiofosfolipidos del tipo eter.

Info

Publication number
ES2145223T3
ES2145223T3 ES95306514T ES95306514T ES2145223T3 ES 2145223 T3 ES2145223 T3 ES 2145223T3 ES 95306514 T ES95306514 T ES 95306514T ES 95306514 T ES95306514 T ES 95306514T ES 2145223 T3 ES2145223 T3 ES 2145223T3
Authority
ES
Spain
Prior art keywords
thiophospholipids
ether type
production procedure
chem
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95306514T
Other languages
English (en)
Inventor
Mitsuaki Ohtani
Masahiro Fuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2145223T3 publication Critical patent/ES2145223T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/06—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PROPORCIONA UN METODO PARA PRODUCIR UN TIOFOSFOLIPIDO DE TIPO ETER DE LA FORMULA (I): EN DONDE: N ES UN ENTERO DE 13 A 17; A ES UN GRUPO ACILO C{SUB, 14}-C{SUB, 20}; G ES UN GRUPO SELECCIONADO DEL GRUPO QUE CONSTA DE: EL CUAL ES UTIL COMO UN SUSTRATO SINTETICO DE INHIBIDORES A{SUB, 2} DE FOSFOLIPASA CITOSOLICA, SIENDO DICHO METODO APLICABLE A PRODUCCION EN BRUTO DEL COMPUESTO (I), INTERMEDIARIOS DEL MISMO Y LA PREPARACION DE ESTOS.
ES95306514T 1994-09-20 1995-09-15 Procedimiento de produccion de tiofosfolipidos del tipo eter. Expired - Lifetime ES2145223T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22467994A JP3839857B2 (ja) 1994-09-20 1994-09-20 エーテル型チオリン脂質化合物の製造方法

Publications (1)

Publication Number Publication Date
ES2145223T3 true ES2145223T3 (es) 2000-07-01

Family

ID=16817531

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95306514T Expired - Lifetime ES2145223T3 (es) 1994-09-20 1995-09-15 Procedimiento de produccion de tiofosfolipidos del tipo eter.

Country Status (12)

Country Link
US (3) US5663405A (es)
EP (1) EP0703237B1 (es)
JP (1) JP3839857B2 (es)
KR (1) KR100367438B1 (es)
AT (1) ATE190979T1 (es)
CA (1) CA2158381A1 (es)
DE (1) DE69515770T2 (es)
DK (1) DK0703237T3 (es)
ES (1) ES2145223T3 (es)
GR (1) GR3033172T3 (es)
PT (1) PT703237E (es)
TW (1) TW294671B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6130211A (en) * 1996-05-28 2000-10-10 Kerix, L.L.C. Phosphocholinate cardenolides
DE102009052034A1 (de) * 2009-11-05 2011-05-12 Merck Patent Gmbh Synthese von Phosphorestern
EP2844688B1 (en) 2012-05-02 2020-06-03 Lubrizol Advanced Materials, Inc. Aromatic dispersant composition
US10150838B2 (en) 2013-08-29 2018-12-11 Lubrizol Advanced Materials, Inc. Non-fused aromatic dispersant composition
CN106967113A (zh) * 2017-04-05 2017-07-21 西北农林科技大学 血小板活化因子衍生物及其合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221696A (en) * 1989-03-29 1993-06-22 Alcon Laboratories, Inc. Use of monoacyl phosphoglycerides to enhance the corneal penetration of ophthalmic drugs
JP2899061B2 (ja) * 1990-05-18 1999-06-02 協和メデックス株式会社 カルシウムの定量法
JP3204681B2 (ja) 1991-05-24 2001-09-04 株式会社シノテスト 新規なエーテル型チオリン脂質化合物およびその製造法
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5464754A (en) * 1993-08-17 1995-11-07 The Regents Of The University Of California Assay and substrate for arachidonoyl-specific phospholipase A2
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel

Also Published As

Publication number Publication date
KR100367438B1 (ko) 2003-03-15
JP3839857B2 (ja) 2006-11-01
DE69515770D1 (de) 2000-04-27
KR960010665A (ko) 1996-04-20
JPH0892265A (ja) 1996-04-09
US5981778A (en) 1999-11-09
TW294671B (es) 1997-01-01
US5663405A (en) 1997-09-02
GR3033172T3 (en) 2000-08-31
CA2158381A1 (en) 1996-03-21
EP0703237B1 (en) 2000-03-22
PT703237E (pt) 2000-07-31
ATE190979T1 (de) 2000-04-15
EP0703237A1 (en) 1996-03-27
DK0703237T3 (da) 2000-07-10
DE69515770T2 (de) 2000-07-27
US5760270A (en) 1998-06-02

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