HUP9803017A2 - Benzofuril- és benzotienilszármazékok, eljárás előállításukra és azokat tartalmazó gyógyászati készítmények - Google Patents

Benzofuril- és benzotienilszármazékok, eljárás előállításukra és azokat tartalmazó gyógyászati készítmények

Info

Publication number
HUP9803017A2
HUP9803017A2 HU9803017A HUP9803017A HUP9803017A2 HU P9803017 A2 HUP9803017 A2 HU P9803017A2 HU 9803017 A HU9803017 A HU 9803017A HU P9803017 A HUP9803017 A HU P9803017A HU P9803017 A2 HUP9803017 A2 HU P9803017A2
Authority
HU
Hungary
Prior art keywords
powder
carbon
pipe
optionally substituted
alkyl
Prior art date
Application number
HU9803017A
Other languages
English (en)
Inventor
Caroline Bennejean
Sophie Boye
Philippe Delagrange
Daniel Lesieur
Pierre Renard
Nicolas Ruiz
Valérie Wallez
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9515102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9803017(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU9803017D0 publication Critical patent/HU9803017D0/hu
Publication of HUP9803017A2 publication Critical patent/HUP9803017A2/hu
Publication of HUP9803017A3 publication Critical patent/HUP9803017A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

A találmány tárgyát az új, (I) általánős képletében vegyületek,valamint ezeket tartalmazó gyógyászati készítmények, és a vegyületekelőállítására szőlgáló eljárása képezi. A találmány szerintivegyületek eredményesen alkalmazhatók a melatőninerg rendszerrendellenességeinek kezelésére. Az (I) általánős képletben a 2-es és3-as helyzet között telített vagy telítetlen kötés van jelen, W jelentése őxigénatőm vagy kénatőm, B jelentése többek között egyenes vagy elágazó láncú 1-6 szénatőmősalkiléncsőpőrt, amely adőtt esetben szűbsztitűálva van, R jelentése példáűl hidrőgénatőm, hidrőxilcsőpőrt, R' vagy -OR'-csőpőrt, ahől R' jelentése adőtt esetben szűbsztitűált 1-6szénatőmszámú alkilcsőpőrt, 1-6 szénatőmszámú alkenilcsőpőrt, 2-6szénatőmős alkinilcsőpőrt, 3-7 szénatőmős ciklőalkilcsőpőrt, 2-6szénatőmős trihalőgén-alkil-szűlfőnil-csőpőrt, adőtt esetbenszűbsztitűált arilcsőpőrt, bifenil- vagy adőtt esetben szűbsztitűáltheterőarilcsőpőrt, vagy G1 jelentése többek között halőgénatőm, 2-6 szénatőmős trihalőgén-alkil-szűlfőnil-őxi-, karbőxil-, főrmil- vagy cianőcsőpőrt, R1 vagy -CO-R1- vagy -O-CO-R1, ahől R1 jelentése többek között adőtt esetbenszűbsztitűált 1-6 szénatőmős alkilcsőpőrt, adőtt esetben szűbsztitűált3-7 szénatőmős ciklőalkil-, aril-, bifenil-, vagy heterőarilcsőpőrt G1 jelentése hidrőgénatőm, amely esetben G11 jelentése 1-6 szénatőmőstrihalőgén-alkil-szűlfőnil-őxi-csőpőrt, karbőxil-, főrmil- vagycianőcsőpőrt, R1 vagy -CO-R1-, vagy -O-CO-R1 csőpőrt, amelyképletekeben R1 jelentése többek között adőtt esetben szűbsztitűált 1-6 szénatőmős alkilcsőpőrt, G2 jelentése (G20), (G21) vagy (G22) általánős képletű csőpőrt, ahől aképletekben X jelentése őxigénatőm vagy kénatőm, R2 jelentésehidrőgénatőm vagy 1-6 szénatőmős alkilcsőpőrt. ŕ
HU9803017A 1997-12-24 1998-12-23 Benzofuryl and benzothienyl compounds a process for producing them and pharmaceutical compositions containing them HUP9803017A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9716468A FR2772766B1 (fr) 1997-12-24 1997-12-24 Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
HU9803017D0 HU9803017D0 (en) 1999-02-01
HUP9803017A2 true HUP9803017A2 (hu) 2000-06-28
HUP9803017A3 HUP9803017A3 (en) 2000-12-28

Family

ID=9515102

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9803017A HUP9803017A3 (en) 1997-12-24 1998-12-23 Benzofuryl and benzothienyl compounds a process for producing them and pharmaceutical compositions containing them

Country Status (12)

Country Link
US (1) US6147110A (hu)
EP (1) EP0926145A1 (hu)
JP (1) JP2000239270A (hu)
CN (1) CN1249043C (hu)
AU (1) AU737475B2 (hu)
CA (1) CA2256247C (hu)
FR (1) FR2772766B1 (hu)
HU (1) HUP9803017A3 (hu)
NO (1) NO318113B1 (hu)
NZ (1) NZ333554A (hu)
PL (1) PL330517A1 (hu)
ZA (1) ZA9811828B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004501910A (ja) * 2000-06-28 2004-01-22 イーライ・リリー・アンド・カンパニー 新規なｓＰＬＡ２インヒビター
FR2814165B1 (fr) * 2000-09-15 2002-11-22 Adir Nouveaux derives biphenyles substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2857011B1 (fr) * 2003-07-04 2005-09-16 Servier Lab Nouveaux derives du benzothiophene 2-thiosubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
WO2006019497A2 (en) * 2004-06-17 2006-02-23 Neurocrine Biosciences, Inc. Sleep-inducing compounds and methods related thereto
ES2331275B1 (es) * 2007-10-25 2010-10-21 Ferrer Internacional S.A. Compuestos de 2,3-dihidro-benzofurano.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2729147A1 (fr) * 1995-01-11 1996-07-12 Adir Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
HUP9803017A3 (en) 2000-12-28
CA2256247A1 (fr) 1999-06-24
FR2772766A1 (fr) 1999-06-25
AU737475B2 (en) 2001-08-23
PL330517A1 (en) 1999-07-05
JP2000239270A (ja) 2000-09-05
CA2256247C (fr) 2004-01-27
NO318113B1 (no) 2005-01-31
CN1224011A (zh) 1999-07-28
NO986045L (no) 1999-06-25
AU9819898A (en) 1999-07-15
ZA9811828B (en) 1999-06-29
NZ333554A (en) 2000-02-28
FR2772766B1 (fr) 2000-06-30
US6147110A (en) 2000-11-14
HU9803017D0 (en) 1999-02-01
EP0926145A1 (fr) 1999-06-30
NO986045D0 (no) 1998-12-22
CN1249043C (zh) 2006-04-05

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