ES2028886T3 - Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico. - Google Patents

Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico.

Info

Publication number
ES2028886T3
ES2028886T3 ES198787400598T ES87400598T ES2028886T3 ES 2028886 T3 ES2028886 T3 ES 2028886T3 ES 198787400598 T ES198787400598 T ES 198787400598T ES 87400598 T ES87400598 T ES 87400598T ES 2028886 T3 ES2028886 T3 ES 2028886T3
Authority
ES
Spain
Prior art keywords
dicarboxylic acid
group
dysimetric
dihydropyridine
hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787400598T
Other languages
English (en)
Inventor
Jacques Robin
Didier Pruneau
Francois Bellamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Innovation et Synergie SA
Original Assignee
Fournier Innovation et Synergie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Innovation et Synergie SA filed Critical Fournier Innovation et Synergie SA
Application granted granted Critical
Publication of ES2028886T3 publication Critical patent/ES2028886T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Coloring (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Laminated Bodies (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE NUEVOS ESTERES ASIMETRICOS DERIVADOS DEL ACIDO 1,4-DIHIDROPIRIDIN-3,5-DICARBOXILICO DE FORMULA (I), EN LA QUE R1 REPRESENTA UN GRUPO ALQUILO DE 1 A 4 CARBONOS, UN GRUPO BENCILO, UN GRUPO BENZOILO O UN GRUPO FENILO EVENTUALMENTE SUSTITUIDO CON UNO O VARIOS GRUPOS ALCOXI DE 1 A 4 CARBONOS, ALQUILO DE 1 A 4 CARBONOS, CIANO, NITRO, HIDROXI, TRIFLUOROMETILO, O CON UNO O VARIOS ATOMOS DE HALOGENO, R3 Y R4, IDENTICOS O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO, UN GRUPO NITRO O UN ATOMO DE CLORO, SUS ISOMEROS OPTICOS Y DIASTEREOISOMEROS, ASI COMO LAS SALES DE ADICION CORRESPONDIENTES. ESTOS NUEVOS ESTERES SON UTILES EN TERAPEUTICA, ESPECIALMENTE, COMO AGENTES ANTIHIPERTENSORES.
ES198787400598T 1986-04-02 1987-03-18 Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico. Expired - Lifetime ES2028886T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8604685A FR2596760B1 (fr) 1986-04-02 1986-04-02 Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique

Publications (1)

Publication Number Publication Date
ES2028886T3 true ES2028886T3 (es) 1992-07-16

Family

ID=9333794

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787400598T Expired - Lifetime ES2028886T3 (es) 1986-04-02 1987-03-18 Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico.

Country Status (25)

Country Link
US (2) US4806544A (es)
EP (1) EP0240398B1 (es)
JP (1) JPS6317883A (es)
KR (1) KR900005956B1 (es)
CN (1) CN1015460B (es)
AT (1) ATE63555T1 (es)
AU (2) AU590690B2 (es)
CS (1) CS268828B2 (es)
DD (2) DD263291A5 (es)
DE (1) DE3770037D1 (es)
DK (1) DK161787A (es)
ES (1) ES2028886T3 (es)
FI (1) FI86302C (es)
FR (1) FR2596760B1 (es)
GR (1) GR3002267T3 (es)
HU (2) HU199479B (es)
IL (1) IL81933A (es)
NO (1) NO167029C (es)
NZ (1) NZ219758A (es)
OA (1) OA08508A (es)
PT (1) PT84560B (es)
SU (1) SU1586515A3 (es)
TN (1) TNSN87043A1 (es)
YU (2) YU57287A (es)
ZA (1) ZA872258B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0506801A1 (de) * 1989-12-22 1992-10-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue dihydropyridine
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
WO1993006082A1 (en) * 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
WO2010109299A2 (en) * 2009-03-27 2010-09-30 Council Of Scientific & Industrial Research Substituted 1, 4-dioxa-8-azaspiro [4,5] decanes useful as fungicides and a process for the preparation thereof
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102796111B (zh) * 2012-09-10 2014-09-24 贵州大学 氧氮杂螺环酰胺基团的羧(磺)酸酯类化合物及制备方法和用途
CN104860873A (zh) * 2015-05-28 2015-08-26 石家庄学院 一种(s)-1,4-二氢吡啶钙离子拮抗剂的制备方法
WO2017063307A1 (zh) * 2015-10-13 2017-04-20 山东轩竹医药科技有限公司 1，4-二氢吡啶-3，5-二羧酸酯衍生物的制备方法及中间体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
GB1245087A (en) * 1967-10-26 1971-09-02 Wyeth John & Brother Ltd Heterocyclic compounds
JPS4932542B1 (es) * 1970-08-17 1974-08-31
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
US4250312A (en) * 1979-12-28 1981-02-10 Argus Chemical Corp. Process for preparing 4-piperidone spiroketal compounds
US4250313A (en) * 1980-02-01 1981-02-10 Argus Chemical Corp. Process for preparing 4-piperidone spiroketal compounds
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58159462A (ja) * 1982-03-17 1983-09-21 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
WO1983003249A1 (en) * 1982-03-17 1983-09-29 Yoshitomi Pharmaceutical 1,4-dihydropyridine-3,5-dicarboxylate derivatives
FR2577552B1 (fr) * 1985-02-20 1987-09-04 Sori Soc Rech Ind Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
IL81933A0 (en) 1987-10-20
SU1586515A3 (ru) 1990-08-15
EP0240398A1 (fr) 1987-10-07
CS229287A2 (en) 1989-08-14
CN87102452A (zh) 1987-10-14
JPS6317883A (ja) 1988-01-25
FI871316A0 (fi) 1987-03-25
NO871339L (no) 1987-10-05
ZA872258B (en) 1987-11-25
KR900005956B1 (ko) 1990-08-18
CS268828B2 (en) 1990-04-11
PT84560B (pt) 1989-11-30
AU4126389A (en) 1989-12-21
AU590690B2 (en) 1989-11-09
US4900833A (en) 1990-02-13
YU57287A (en) 1988-10-31
YU44714B (en) 1990-12-31
NO167029B (no) 1991-06-17
DD278793A5 (de) 1990-05-16
ATE63555T1 (de) 1991-06-15
FR2596760A1 (fr) 1987-10-09
DK161787D0 (da) 1987-03-30
IL81933A (en) 1991-06-30
CN1015460B (zh) 1992-02-12
US4806544A (en) 1989-02-21
AU7041087A (en) 1987-10-08
DE3770037D1 (de) 1991-06-20
FI86302B (fi) 1992-04-30
HUT49613A (en) 1989-10-30
GR3002267T3 (en) 1992-12-30
HUT53080A (en) 1990-09-28
PT84560A (fr) 1987-04-01
NZ219758A (en) 1989-04-26
AU610753B2 (en) 1991-05-23
EP0240398B1 (fr) 1991-05-15
TNSN87043A1 (fr) 1990-01-01
NO871339D0 (no) 1987-03-31
KR870010055A (ko) 1987-11-30
HU199479B (en) 1990-02-28
DK161787A (da) 1987-10-03
YU48088A (en) 1988-12-31
FI871316A (fi) 1987-10-03
FR2596760B1 (fr) 1988-12-09
FI86302C (fi) 1992-08-10
NO167029C (no) 1991-09-25
DD263291A5 (de) 1988-12-28
OA08508A (fr) 1988-07-29

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