ES2028886T3 - Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico. - Google Patents
Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico.Info
- Publication number
- ES2028886T3 ES2028886T3 ES198787400598T ES87400598T ES2028886T3 ES 2028886 T3 ES2028886 T3 ES 2028886T3 ES 198787400598 T ES198787400598 T ES 198787400598T ES 87400598 T ES87400598 T ES 87400598T ES 2028886 T3 ES2028886 T3 ES 2028886T3
- Authority
- ES
- Spain
- Prior art keywords
- dicarboxylic acid
- group
- dysimetric
- dihydropyridine
- hetero
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Photoreceptors In Electrophotography (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Coloring (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Laminated Bodies (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
LA PRESENTE INVENCION TRATA DE NUEVOS ESTERES ASIMETRICOS DERIVADOS DEL ACIDO 1,4-DIHIDROPIRIDIN-3,5-DICARBOXILICO DE FORMULA (I), EN LA QUE R1 REPRESENTA UN GRUPO ALQUILO DE 1 A 4 CARBONOS, UN GRUPO BENCILO, UN GRUPO BENZOILO O UN GRUPO FENILO EVENTUALMENTE SUSTITUIDO CON UNO O VARIOS GRUPOS ALCOXI DE 1 A 4 CARBONOS, ALQUILO DE 1 A 4 CARBONOS, CIANO, NITRO, HIDROXI, TRIFLUOROMETILO, O CON UNO O VARIOS ATOMOS DE HALOGENO, R3 Y R4, IDENTICOS O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO, UN GRUPO NITRO O UN ATOMO DE CLORO, SUS ISOMEROS OPTICOS Y DIASTEREOISOMEROS, ASI COMO LAS SALES DE ADICION CORRESPONDIENTES. ESTOS NUEVOS ESTERES SON UTILES EN TERAPEUTICA, ESPECIALMENTE, COMO AGENTES ANTIHIPERTENSORES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8604685A FR2596760B1 (fr) | 1986-04-02 | 1986-04-02 | Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2028886T3 true ES2028886T3 (es) | 1992-07-16 |
Family
ID=9333794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787400598T Expired - Lifetime ES2028886T3 (es) | 1986-04-02 | 1987-03-18 | Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico. |
Country Status (25)
Country | Link |
---|---|
US (2) | US4806544A (es) |
EP (1) | EP0240398B1 (es) |
JP (1) | JPS6317883A (es) |
KR (1) | KR900005956B1 (es) |
CN (1) | CN1015460B (es) |
AT (1) | ATE63555T1 (es) |
AU (2) | AU590690B2 (es) |
CS (1) | CS268828B2 (es) |
DD (2) | DD263291A5 (es) |
DE (1) | DE3770037D1 (es) |
DK (1) | DK161787A (es) |
ES (1) | ES2028886T3 (es) |
FI (1) | FI86302C (es) |
FR (1) | FR2596760B1 (es) |
GR (1) | GR3002267T3 (es) |
HU (2) | HU199479B (es) |
IL (1) | IL81933A (es) |
NO (1) | NO167029C (es) |
NZ (1) | NZ219758A (es) |
OA (1) | OA08508A (es) |
PT (1) | PT84560B (es) |
SU (1) | SU1586515A3 (es) |
TN (1) | TNSN87043A1 (es) |
YU (2) | YU57287A (es) |
ZA (1) | ZA872258B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0506801A1 (de) * | 1989-12-22 | 1992-10-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue dihydropyridine |
DE4125271A1 (de) * | 1991-07-31 | 1993-02-11 | Bayer Ag | Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester |
WO1993006082A1 (en) * | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
WO2010109299A2 (en) * | 2009-03-27 | 2010-09-30 | Council Of Scientific & Industrial Research | Substituted 1, 4-dioxa-8-azaspiro [4,5] decanes useful as fungicides and a process for the preparation thereof |
WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
CN102796111B (zh) * | 2012-09-10 | 2014-09-24 | 贵州大学 | 氧氮杂螺环酰胺基团的羧(磺)酸酯类化合物及制备方法和用途 |
CN104860873A (zh) * | 2015-05-28 | 2015-08-26 | 石家庄学院 | 一种(s)-1,4-二氢吡啶钙离子拮抗剂的制备方法 |
WO2017063307A1 (zh) * | 2015-10-13 | 2017-04-20 | 山东轩竹医药科技有限公司 | 1,4-二氢吡啶-3,5-二羧酸酯衍生物的制备方法及中间体 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670824C3 (de) * | 1967-03-20 | 1978-08-03 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridin-33-dicarbonsäurealkylester |
GB1245087A (en) * | 1967-10-26 | 1971-09-02 | Wyeth John & Brother Ltd | Heterocyclic compounds |
JPS4932542B1 (es) * | 1970-08-17 | 1974-08-31 | ||
GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
US4250312A (en) * | 1979-12-28 | 1981-02-10 | Argus Chemical Corp. | Process for preparing 4-piperidone spiroketal compounds |
US4250313A (en) * | 1980-02-01 | 1981-02-10 | Argus Chemical Corp. | Process for preparing 4-piperidone spiroketal compounds |
DE3208628A1 (de) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS58159462A (ja) * | 1982-03-17 | 1983-09-21 | Yoshitomi Pharmaceut Ind Ltd | 1,4−ジヒドロピリジン−3,5−ジカルボン酸エステル誘導体 |
WO1983003249A1 (en) * | 1982-03-17 | 1983-09-29 | Yoshitomi Pharmaceutical | 1,4-dihydropyridine-3,5-dicarboxylate derivatives |
FR2577552B1 (fr) * | 1985-02-20 | 1987-09-04 | Sori Soc Rech Ind | Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique |
-
1986
- 1986-04-02 FR FR8604685A patent/FR2596760B1/fr not_active Expired
-
1987
- 1987-03-18 DE DE8787400598T patent/DE3770037D1/de not_active Expired - Fee Related
- 1987-03-18 ES ES198787400598T patent/ES2028886T3/es not_active Expired - Lifetime
- 1987-03-18 US US07/027,262 patent/US4806544A/en not_active Expired - Fee Related
- 1987-03-18 AT AT87400598T patent/ATE63555T1/de not_active IP Right Cessation
- 1987-03-18 EP EP87400598A patent/EP0240398B1/fr not_active Expired - Lifetime
- 1987-03-18 IL IL81933A patent/IL81933A/xx unknown
- 1987-03-19 AU AU70410/87A patent/AU590690B2/en not_active Ceased
- 1987-03-24 NZ NZ219758A patent/NZ219758A/xx unknown
- 1987-03-25 TN TNTNSN87043A patent/TNSN87043A1/fr unknown
- 1987-03-25 FI FI871316A patent/FI86302C/fi not_active IP Right Cessation
- 1987-03-26 PT PT84560A patent/PT84560B/pt not_active IP Right Cessation
- 1987-03-27 ZA ZA872258A patent/ZA872258B/xx unknown
- 1987-03-30 DK DK161787A patent/DK161787A/da not_active IP Right Cessation
- 1987-03-31 NO NO871339A patent/NO167029C/no unknown
- 1987-03-31 OA OA59099A patent/OA08508A/xx unknown
- 1987-04-01 HU HU871403A patent/HU199479B/hu unknown
- 1987-04-01 CS CS872292A patent/CS268828B2/cs unknown
- 1987-04-01 KR KR1019870003078A patent/KR900005956B1/ko not_active IP Right Cessation
- 1987-04-01 YU YU00572/87A patent/YU57287A/xx unknown
- 1987-04-01 HU HU893897A patent/HUT53080A/hu unknown
- 1987-04-01 SU SU874202348A patent/SU1586515A3/ru active
- 1987-04-01 CN CN87102452A patent/CN1015460B/zh not_active Expired
- 1987-04-01 DD DD87301364A patent/DD263291A5/de not_active IP Right Cessation
- 1987-04-01 DD DD87325139A patent/DD278793A5/de not_active IP Right Cessation
- 1987-04-02 JP JP62083694A patent/JPS6317883A/ja active Pending
-
1988
- 1988-03-09 YU YU480/88A patent/YU44714B/xx unknown
- 1988-09-22 US US07/249,402 patent/US4900833A/en not_active Expired - Fee Related
-
1989
- 1989-09-11 AU AU41263/89A patent/AU610753B2/en not_active Ceased
-
1991
- 1991-07-05 GR GR91400959T patent/GR3002267T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69100079D1 (de) | Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
DK160877C (da) | Fremgangsmaade til fremstilling af 2-penemforbindelser | |
DK0490566T3 (da) | Fremstilling og anvendelse af N-iodpropargyloxycarbonylaminosyreestere og derivater som antimikrobielle midler | |
ES2028886T3 (es) | Procedimiento de preparacion de un derivado ester heterociclico disimetrico del acido 1,4-dihidropiridina-3,5-dicarboxilico. | |
ES8307260A1 (es) | Procedimiento para la obtencion de derivados de trifluormetil-fenoxifenil-silicio. | |
DK12584A (da) | Bicyclo(4.2.0)1,3,5-octatrienderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende disse | |
DE3866292D1 (de) | Piperazinylalkylpiperazindion-derivate, ihre verfahren zur herstellung und diese enthaltende pharmazeutische zusammenstellungen. | |
SE8800846L (sv) | Optiskt aktiva oxo-isoindolinderivat | |
DK469285A (da) | Thiadiazolderivater, der indvirker paa centralnervesystemet, fremgangsmaade til fremstilling deraf og midler indeholdende derivaterne | |
FR2674246B1 (fr) | Nouveaux derives de l'acide alpha-methylene 5-thiazolacetique, leur procede de preparation et les intermediaires de ce procede, leur application a titre de fongicides et les compositions les renfermant. | |
KR910004632A (ko) | 신규한 1-옥사-2-옥소-8-아자스피로[4,5]데칸 유도체와 그들을 포함하는 약제학적 조성물 및 그 제조방법 | |
SE8204791D0 (sv) | Process for preparing alkoxy-vincaminic acid esters and alkoxy-apovincaminic acid esters | |
ATE17710T1 (de) | Keten-0,0-acetale und verfahren zu ihrer herstellung. | |
DK0763516T3 (da) | Fremstilling og anvendelse af rene enantiomerer af 8-halogen-6-hydroxyoctansyrer, deres alkylestere og deres salte med rene enantiomerer af alfa-methylbenzylamin | |
ES8105291A1 (es) | Procedimiento para la obtencion de derivados del decahidro- quinolinol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 240398 Country of ref document: ES |