PT84560B - Processo para a preparacao de derivados dissimetricos do acido 1,4-di- -hidropiridino-3,5-dicarboxilico - Google Patents

Processo para a preparacao de derivados dissimetricos do acido 1,4-di- -hidropiridino-3,5-dicarboxilico

Info

Publication number
PT84560B
PT84560B PT84560A PT8456087A PT84560B PT 84560 B PT84560 B PT 84560B PT 84560 A PT84560 A PT 84560A PT 8456087 A PT8456087 A PT 8456087A PT 84560 B PT84560 B PT 84560B
Authority
PT
Portugal
Prior art keywords
group
dicarboxylic acid
dissimetric
dihydropyridine
derivatives
Prior art date
Application number
PT84560A
Other languages
English (en)
Other versions
PT84560A (fr
Inventor
Francois Bellamy
Didier Pruneau
Jacques Robin
Original Assignee
Fournier Innovation Synergie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Innovation Synergie filed Critical Fournier Innovation Synergie
Publication of PT84560A publication Critical patent/PT84560A/pt
Publication of PT84560B publication Critical patent/PT84560B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Coloring (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Laminated Bodies (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT84560A 1986-04-02 1987-03-26 Processo para a preparacao de derivados dissimetricos do acido 1,4-di- -hidropiridino-3,5-dicarboxilico PT84560B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8604685A FR2596760B1 (fr) 1986-04-02 1986-04-02 Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique

Publications (2)

Publication Number Publication Date
PT84560A PT84560A (fr) 1987-04-01
PT84560B true PT84560B (pt) 1989-11-30

Family

ID=9333794

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84560A PT84560B (pt) 1986-04-02 1987-03-26 Processo para a preparacao de derivados dissimetricos do acido 1,4-di- -hidropiridino-3,5-dicarboxilico

Country Status (25)

Country Link
US (2) US4806544A (pt)
EP (1) EP0240398B1 (pt)
JP (1) JPS6317883A (pt)
KR (1) KR900005956B1 (pt)
CN (1) CN1015460B (pt)
AT (1) ATE63555T1 (pt)
AU (2) AU590690B2 (pt)
CS (1) CS268828B2 (pt)
DD (2) DD278793A5 (pt)
DE (1) DE3770037D1 (pt)
DK (1) DK161787A (pt)
ES (1) ES2028886T3 (pt)
FI (1) FI86302C (pt)
FR (1) FR2596760B1 (pt)
GR (1) GR3002267T3 (pt)
HU (2) HUT53080A (pt)
IL (1) IL81933A (pt)
NO (1) NO167029C (pt)
NZ (1) NZ219758A (pt)
OA (1) OA08508A (pt)
PT (1) PT84560B (pt)
SU (1) SU1586515A3 (pt)
TN (1) TNSN87043A1 (pt)
YU (2) YU57287A (pt)
ZA (1) ZA872258B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0506801A1 (de) * 1989-12-22 1992-10-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue dihydropyridine
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
WO1993006082A1 (en) * 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US8841296B2 (en) 2009-03-27 2014-09-23 Council of Scientific and Industrial Research, Anusandhan Bhawan, Rafi Marg Substituted 1, 4-dioxa-8-azaspiro[4,5]decanes useful as fungicides and a process for the preparation thereof
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102796111B (zh) * 2012-09-10 2014-09-24 贵州大学 氧氮杂螺环酰胺基团的羧(磺)酸酯类化合物及制备方法和用途
CN104860873A (zh) * 2015-05-28 2015-08-26 石家庄学院 一种(s)-1,4-二氢吡啶钙离子拮抗剂的制备方法
WO2017063307A1 (zh) * 2015-10-13 2017-04-20 山东轩竹医药科技有限公司 1，4-二氢吡啶-3，5-二羧酸酯衍生物的制备方法及中间体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
GB1245087A (en) * 1967-10-26 1971-09-02 Wyeth John & Brother Ltd Heterocyclic compounds
JPS4932542B1 (pt) * 1970-08-17 1974-08-31
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
US4250312A (en) * 1979-12-28 1981-02-10 Argus Chemical Corp. Process for preparing 4-piperidone spiroketal compounds
US4250313A (en) * 1980-02-01 1981-02-10 Argus Chemical Corp. Process for preparing 4-piperidone spiroketal compounds
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
WO1983003249A1 (en) * 1982-03-17 1983-09-29 Yoshitomi Pharmaceutical 1,4-dihydropyridine-3,5-dicarboxylate derivatives
JPS58159462A (ja) * 1982-03-17 1983-09-21 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
FR2577552B1 (fr) * 1985-02-20 1987-09-04 Sori Soc Rech Ind Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
JPS6317883A (ja) 1988-01-25
SU1586515A3 (ru) 1990-08-15
KR900005956B1 (ko) 1990-08-18
EP0240398B1 (fr) 1991-05-15
CS268828B2 (en) 1990-04-11
DK161787D0 (da) 1987-03-30
PT84560A (fr) 1987-04-01
HU199479B (en) 1990-02-28
DK161787A (da) 1987-10-03
IL81933A (en) 1991-06-30
US4806544A (en) 1989-02-21
YU44714B (en) 1990-12-31
FR2596760B1 (fr) 1988-12-09
FI871316A0 (fi) 1987-03-25
NO167029B (no) 1991-06-17
DD278793A5 (de) 1990-05-16
AU590690B2 (en) 1989-11-09
NZ219758A (en) 1989-04-26
NO871339D0 (no) 1987-03-31
GR3002267T3 (en) 1992-12-30
CN87102452A (zh) 1987-10-14
AU610753B2 (en) 1991-05-23
ATE63555T1 (de) 1991-06-15
YU48088A (en) 1988-12-31
NO167029C (no) 1991-09-25
YU57287A (en) 1988-10-31
FR2596760A1 (fr) 1987-10-09
OA08508A (fr) 1988-07-29
EP0240398A1 (fr) 1987-10-07
HUT53080A (en) 1990-09-28
DE3770037D1 (de) 1991-06-20
CN1015460B (zh) 1992-02-12
ES2028886T3 (es) 1992-07-16
FI871316A (fi) 1987-10-03
FI86302C (fi) 1992-08-10
TNSN87043A1 (fr) 1990-01-01
ZA872258B (en) 1987-11-25
FI86302B (fi) 1992-04-30
HUT49613A (en) 1989-10-30
AU7041087A (en) 1987-10-08
CS229287A2 (en) 1989-08-14
IL81933A0 (en) 1987-10-20
AU4126389A (en) 1989-12-21
DD263291A5 (de) 1988-12-28
KR870010055A (ko) 1987-11-30
NO871339L (no) 1987-10-05
US4900833A (en) 1990-02-13

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Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19921130