RO121815B1 - Derivaţi pentaciclici substituiţi, compoziţie farmaceutică ce îi conţine şi utilizarea acestora ca inhibitori de neuraminidază - Google Patents

Derivaţi pentaciclici substituiţi, compoziţie farmaceutică ce îi conţine şi utilizarea acestora ca inhibitori de neuraminidază Download PDF

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Publication number
RO121815B1
RO121815B1 ROA200000635A RO200000635A RO121815B1 RO 121815 B1 RO121815 B1 RO 121815B1 RO A200000635 A ROA200000635 A RO A200000635A RO 200000635 A RO200000635 A RO 200000635A RO 121815 B1 RO121815 B1 RO 121815B1
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Romania
Prior art keywords
acetylamino
methyl
ethyl
carboxylate
amino
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ROA200000635A
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English (en)
Romanian (ro)
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S. Babu Yarlagadda
Chand Pooran
John A. Montgomery
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Biocryst Pharmaceuticals, Inc.
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Publication of RO121815B1 publication Critical patent/RO121815B1/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/14—Compounds containing azido groups with azido groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
ROA200000635A 1997-12-17 1998-12-17 Derivaţi pentaciclici substituiţi, compoziţie farmaceutică ce îi conţine şi utilizarea acestora ca inhibitori de neuraminidază RO121815B1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6995697P 1997-12-17 1997-12-17
US8525298P 1998-05-13 1998-05-13
PCT/US1998/026871 WO1999033781A1 (en) 1997-12-17 1998-12-17 Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors

Publications (1)

Publication Number Publication Date
RO121815B1 true RO121815B1 (ro) 2008-05-30

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ROA200000635A RO121815B1 (ro) 1997-12-17 1998-12-17 Derivaţi pentaciclici substituiţi, compoziţie farmaceutică ce îi conţine şi utilizarea acestora ca inhibitori de neuraminidază

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US (1) US6562861B1 (enExample)
EP (1) EP1040094B9 (enExample)
JP (3) JP4102022B2 (enExample)
KR (1) KR20010024743A (enExample)
CN (1) CN1282316A (enExample)
AR (1) AR016162A1 (enExample)
AT (1) ATE425955T1 (enExample)
AU (1) AU2200199A (enExample)
BE (1) BE2018C032I2 (enExample)
BR (1) BR9813480A (enExample)
CA (1) CA2315262C (enExample)
CY (2) CY1109153T1 (enExample)
DE (1) DE69840674D1 (enExample)
DK (1) DK1040094T3 (enExample)
ES (1) ES2324746T3 (enExample)
FR (1) FR18C1037I2 (enExample)
HU (1) HUP0100142A3 (enExample)
IL (1) IL136812A0 (enExample)
LT (1) LTC1040094I2 (enExample)
NL (1) NL300952I2 (enExample)
NO (1) NO20003084L (enExample)
PL (1) PL196674B1 (enExample)
PT (1) PT1040094E (enExample)
RO (1) RO121815B1 (enExample)
SI (1) SI1040094T1 (enExample)
SK (1) SK8712000A3 (enExample)
WO (1) WO1999033781A1 (enExample)
ZA (1) ZA9811595B (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ412898A3 (cs) 1996-06-14 1999-08-11 Biocryst Pharmaceuticals, Inc. Substituované cyklopentanové sloučeniny, použitelné jako inhibitory neuraminidázy
PT1040094E (pt) * 1997-12-17 2009-06-03 Biocryst Pharm Inc Compostos de ciclopentano e de ciclopenteno substituídos úteis como inibidores da neuraminidase
JP2002521312A (ja) * 1998-04-23 2002-07-16 アボット・ラボラトリーズ ノイラミニダーゼの阻害剤
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) * 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
WO2000028328A1 (en) 1998-11-05 2000-05-18 Biocryst Pharmaceuticals, Inc. New cyclopentane and cyclopentene compounds and use for detecting influenza virus
CN1358170A (zh) * 1999-06-28 2002-07-10 生物晶体药品股份有限公司 (一)－(1s,4r)n－保护4－氨基－2－环戊烯－1－羧酸酯的制备方法
US6762316B1 (en) * 1999-06-28 2004-07-13 Biocryst Pharmaceuticals, Inc. Preparation of substituted cyclopentane and cyclopentene compounds and certain intermediates
SK19042001A3 (sk) * 1999-06-28 2002-04-04 Ortho-Mcneil Pharmaceutical, Inc. Spôsob prípravy substituovaných derivátov cyklopentánu a ich nové kryštalické štruktúry
CA2377287A1 (en) * 1999-06-28 2001-01-04 Biocryst Pharmaceuticals Inc. Preparation of substituted cyclopentane and cyclopentene compounds and certain intermediates
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
US6627396B1 (en) 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
AU2001243253A1 (en) * 2000-02-24 2001-09-03 Biocryst Pharmaceuticals, Inc. Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
CA2397661C (en) * 2000-03-01 2012-01-03 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
AU2001252578A1 (en) * 2000-04-25 2001-11-07 Sankyo Company Limited Preventives for influenza
GB0015324D0 (en) * 2000-06-22 2000-08-16 Biota Scient Management Medicaments
AUPR001000A0 (en) 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US7038059B2 (en) 2000-10-18 2006-05-02 Kuraray Co., Ltd. Process for preparation of 4-n-substituted amino-2-aza-1-oxabicyclo[3.3.0] oct-2-ene-6-carboxylic acid esters and process for preparation of their intermediates
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
US8101745B2 (en) * 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
WO2007087056A2 (en) * 2006-01-13 2007-08-02 Scolr Pharma, Inc. Peramivir derivative for oral administration
BRPI0707769A2 (pt) * 2006-02-13 2011-05-10 Biocryst Pharm Inc tratamentos antivirais intravenosos
US20070203241A1 (en) * 2006-02-13 2007-08-30 Babu Yarlagadda S Antiviral treatments
WO2007117241A1 (en) * 2006-04-12 2007-10-18 Biocryst Pharmaceuticals, Inc. Intramuscular antiviral treatments
US20070244193A1 (en) * 2006-04-12 2007-10-18 Babu Yarlagadda S Intramuscular antiviral treatments
CN100432047C (zh) * 2006-07-03 2008-11-12 华南农业大学 一种抗流感及禽流感病毒药物帕拉米韦的合成方法
AU2008208865B2 (en) 2007-01-23 2013-01-24 Therapicon Srl Antiviral compounds
US20080194801A1 (en) * 2007-02-14 2008-08-14 Swanson Basil I Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
EP2540727B1 (en) 2007-08-02 2018-07-25 Millennium Pharmaceuticals, Inc. Sulfamoylating reagent
CN101367750B (zh) 2007-08-14 2012-05-23 中国人民解放军军事医学科学院毒物药物研究所 (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途
TWI448301B (zh) * 2007-11-05 2014-08-11 Ala Wai Pharma Inc 用於增強經口投與之極性劑的生物可用性之調配物
AU2014200052B2 (en) * 2007-11-05 2016-01-07 Ala Wai Pharma, Inc. Formulations for enhanced bioavailability of orally administered polar agents
CN101538228B (zh) * 2008-03-21 2012-05-30 北京普世康医药技术有限公司 抗流感和禽流感病毒药物化合物帕拉米韦的合成方法
CN101486664B (zh) * 2008-12-31 2013-09-04 北京大学深圳研究生院 用作流感病毒神经氨酸酶抑制剂的多取代五元环小分子化合物
BRPI1010981A2 (pt) 2009-05-15 2018-12-04 Redx Pharma Ltd "derivados de fármaco redox"
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
WO2011150205A2 (en) 2010-05-27 2011-12-01 Dr. Reddy's Laboratories Ltd. Highly selective asymmetric hydroformylation of (1s,4r) or (1r,4s)-2-azabicyclo[2.2.1]hept-5-en-3- one (+) or (-)-lactam
CN102584637B (zh) * 2011-01-17 2014-07-09 天津药物研究院 帕拉米韦水合物晶体、制备方法、药用组合物及其用途
CN102603577A (zh) * 2011-01-19 2012-07-25 董慧珍 一种抗流感和禽流感药物的衍生物及其用途
CN102757365B (zh) * 2011-04-29 2013-10-30 上海泓博智源医药技术有限公司 一种制备帕拉米韦关键中间体的方法
CN103827082B (zh) * 2011-04-29 2016-01-20 上海泓博智源医药技术有限公司 一种制备帕拉米韦及其中间体的新工艺
CN102964267B (zh) * 2011-09-01 2015-06-10 中山大学 一种具有流感病毒神经氨酸酶抑制活性的环己烯化合物及其制备方法以及其应用
CN102863359B (zh) * 2012-05-16 2014-05-07 常州制药厂有限公司 一种抗流感药物的合成方法
CN102702033A (zh) * 2012-06-11 2012-10-03 天津泰普药品科技发展有限公司 无定型帕拉米韦及其制备方法与药物组合物
US9227990B2 (en) 2012-10-29 2016-01-05 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
KR20150130355A (ko) 2013-03-15 2015-11-23 더 리전트 오브 더 유니버시티 오브 캘리포니아 비환식 뉴클레오사이드 포스포네이트 디에스테르
AU2014265483B2 (en) 2013-05-14 2018-08-02 Biocryst Pharmaceuticals, Inc. Anti-influenza compositions and methods
CN105294589B (zh) * 2014-06-18 2017-06-30 朱靖华 一种抗病毒药物及其制备方法
MX377983B (es) 2014-09-15 2025-03-04 Univ California Análogos de nucleótidos.
CN104387288B (zh) * 2014-11-25 2016-04-20 广东东阳光药业有限公司 作为神经氨酸酶抑制剂的化合物及其在药物中的应用
CN104496838B (zh) * 2014-12-03 2016-04-20 广东东阳光药业有限公司 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途
CN104496839B (zh) * 2014-12-03 2016-04-20 广东东阳光药业有限公司 取代环丁烷类神经氨酸酶抑制剂及其使用方法和用途
CN104496857B (zh) * 2014-12-10 2016-10-12 广东东阳光药业有限公司 作为神经氨酸酶抑制剂的化合物及其在药物中的应用
CN105198827A (zh) * 2015-04-13 2015-12-30 广州南新制药有限公司 一种帕拉米韦中间体的合成方法
EA035650B1 (ru) 2015-08-10 2020-07-21 Алжеон, Инк. Композиции и способы лечения и предотвращения нейродегенеративных расстройств
CN106220515A (zh) * 2016-08-12 2016-12-14 郸城巨鑫生物科技有限公司 一种(1r,4s)‑1‑氨基‑4‑羟甲基‑2‑环戊烯盐酸盐的合成方法
CN115025080B (zh) * 2021-03-08 2026-04-14 合肥合源药业有限公司 一种抗流感病毒的药物组合物及其用途
CN118359556A (zh) * 2024-04-08 2024-07-19 泓博智源(开原)药业有限公司 一种帕拉米韦三水合物关键中间体的制备方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT979736B (it) 1972-03-07 1974-09-30 Ethyl Corp Detersivo contenente un sequestran te e relativo metodo di impiego
US4089897A (en) * 1976-05-10 1978-05-16 Minnesota Mining And Manufacturing Company Geminal prostaglandin analogs
US4426391A (en) 1982-09-15 1984-01-17 Merck & Co., Inc. [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa
JPS59163365A (ja) 1983-03-08 1984-09-14 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物
DE3475065D1 (en) 1983-06-23 1988-12-15 Merck & Co Inc (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives
ZA878096B (en) * 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds
US4873019A (en) 1986-12-20 1989-10-10 Merck Patent Gesellschaft Mit Beschrankter Haftung Cyclopentane derivatives
FI923458A0 (fi) * 1990-02-02 1992-07-31 Schering Corp 4,5-cykloalkano-3-benzazepin-7-ol- derivat och deras anvaendning.
WO1992016541A1 (fr) 1991-03-12 1992-10-01 Mect Corporation Synthese de l'acide sianique et intermediaire synthetique utilise pour cette synthese
JP2951765B2 (ja) 1991-09-10 1999-09-20 三共株式会社 エナミノエステル類およびその製法
AU673824B2 (en) * 1992-05-29 1996-11-28 Bayer Aktiengesellschaft Cyclopentane- and -pentene-beta-amino acids
JPH07145120A (ja) * 1993-11-25 1995-06-06 Kuraray Co Ltd ｃｉｓ−４−アミノ−２−シクロペンテン−１−カルボン酸の製造法
WO1995023157A1 (en) * 1994-02-25 1995-08-31 E.I. Du Pont De Nemours And Company 4-n-substituted sialic acids and their sialosides
US5453533A (en) * 1994-04-14 1995-09-26 The University Of Alabama At Birmingham Inhibitors of influenza virus neuraminidase and methods of making and using the same
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
CN100409844C (zh) * 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
CA2176414A1 (en) 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
ATE206116T1 (de) * 1995-05-19 2001-10-15 Biota Scient Management 6-carboxamido-dihydropyran-derivate
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
CZ412898A3 (cs) * 1996-06-14 1999-08-11 Biocryst Pharmaceuticals, Inc. Substituované cyklopentanové sloučeniny, použitelné jako inhibitory neuraminidázy
CA2279927A1 (en) 1997-02-06 1998-08-13 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
KR20010024123A (ko) * 1997-09-17 2001-03-26 헨슬레이 맥스 디. 6-원 고리를 갖는 화합물, 그의 제조 방법 및의약물로서의 용도
PT1040094E (pt) * 1997-12-17 2009-06-03 Biocryst Pharm Inc Compostos de ciclopentano e de ciclopenteno substituídos úteis como inibidores da neuraminidase
WO1999054299A1 (en) 1998-04-23 1999-10-28 Abbott Laboratories Pyrrolidines as inhibitors of neuraminidases
JP2002521312A (ja) 1998-04-23 2002-07-16 アボット・ラボラトリーズ ノイラミニダーゼの阻害剤

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