RO117324B1 - Derivaţi de izoxazolină ca antagonişti ai receptorului fibrinogen - Google Patents
Derivaţi de izoxazolină ca antagonişti ai receptorului fibrinogenInfo
- Publication number
- RO117324B1 RO117324B1 RO97-02195A RO9702195A RO117324B1 RO 117324 B1 RO117324 B1 RO 117324B1 RO 9702195 A RO9702195 A RO 9702195A RO 117324 B1 RO117324 B1 RO 117324B1
- Authority
- RO
- Romania
- Prior art keywords
- receptor antagonists
- isoxazoline
- isoxazoline derivatives
- fibrinogen receptor
- ester
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Prezenta invenţie se referă la derivaţi de izoxazolină, care se prezintă sub formă de promedicament ester sau sare de N[2-(3-(4-formamidinofenil)izoxazolin-5(R)-il)-acetil]-N(n-butiloxicarbonil)- 2,3-(S)-diaminopropionat, esterul menţionat fiind selectat dintre metil, etil sau izopropil, şi sarea menţionată fiind selectată dintre acetat, clorhidrat, benzensulfonat, metansulfonat sau p-toluensulfonat, utili ca antagonişti ai complexului receptor plachetar glicoproteină IIb/fibrinogen IIIa, în compoziţii farmaceutice, care conţin astfel de compuşi, singuri sau în combinaţie cu alţi agenţi terapeutici, pentru inhibarea agregării plachetare, ca trombolitice, şi/sau pentru tratamentul tulburărilor tromboembolice.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/455,436 US5849736A (en) | 1993-11-24 | 1995-05-31 | Isoxazoline and isoxazole fibrinogen receptor antagonists |
PCT/US1996/007692 WO1996038426A1 (en) | 1995-05-31 | 1996-05-30 | Novel isoxazoline and isoxazole fibrinogen receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
RO117324B1 true RO117324B1 (ro) | 2002-01-30 |
Family
ID=23808800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO97-02195A RO117324B1 (ro) | 1995-05-31 | 1996-05-30 | Derivaţi de izoxazolină ca antagonişti ai receptorului fibrinogen |
Country Status (26)
Country | Link |
---|---|
US (2) | US5849736A (ro) |
EP (1) | EP0832076B1 (ro) |
JP (1) | JPH11504651A (ro) |
KR (1) | KR19990022198A (ro) |
CN (1) | CN1202893A (ro) |
AT (1) | ATE245150T1 (ro) |
AU (1) | AU723577B2 (ro) |
BR (1) | BR9609151A (ro) |
CA (1) | CA2222147A1 (ro) |
CZ (1) | CZ374397A3 (ro) |
DE (1) | DE69629116T2 (ro) |
EA (1) | EA000924B1 (ro) |
EE (1) | EE9700312A (ro) |
ES (1) | ES2198483T3 (ro) |
HU (1) | HUP9900102A3 (ro) |
IL (1) | IL118262A (ro) |
LT (1) | LT4416B (ro) |
LV (1) | LV12046B (ro) |
NZ (1) | NZ309944A (ro) |
PL (1) | PL323835A1 (ro) |
RO (1) | RO117324B1 (ro) |
SI (1) | SI9620071A (ro) |
SK (1) | SK162097A3 (ro) |
TW (1) | TW454007B (ro) |
WO (1) | WO1996038426A1 (ro) |
ZA (1) | ZA964486B (ro) |
Families Citing this family (74)
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ATE236890T1 (de) * | 1996-12-23 | 2003-04-15 | Bristol Myers Squibb Pharma Co | Sauerstoff oder schwefel enthaltende 5-gliedrige heteroaromatishe derivative als factor xa hemmer |
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EP1091945A1 (en) | 1998-06-29 | 2001-04-18 | Du Pont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as iib/iiia antagonists |
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KR20220102669A (ko) | 2019-10-16 | 2022-07-20 | 모픽 테라퓨틱, 인코포레이티드 | 인간 인테그린 α4β7의 억제 |
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-
1995
- 1995-05-31 US US08/455,436 patent/US5849736A/en not_active Expired - Lifetime
-
1996
- 1996-05-15 IL IL11826296A patent/IL118262A/xx not_active IP Right Cessation
- 1996-05-30 CA CA002222147A patent/CA2222147A1/en not_active Abandoned
- 1996-05-30 ES ES96917833T patent/ES2198483T3/es not_active Expired - Lifetime
- 1996-05-30 AU AU60243/96A patent/AU723577B2/en not_active Ceased
- 1996-05-30 SI SI9620071A patent/SI9620071A/sl unknown
- 1996-05-30 BR BR9609151A patent/BR9609151A/pt unknown
- 1996-05-30 EE EE9700312A patent/EE9700312A/xx unknown
- 1996-05-30 DE DE69629116T patent/DE69629116T2/de not_active Expired - Fee Related
- 1996-05-30 RO RO97-02195A patent/RO117324B1/ro unknown
- 1996-05-30 WO PCT/US1996/007692 patent/WO1996038426A1/en not_active Application Discontinuation
- 1996-05-30 KR KR1019970708677A patent/KR19990022198A/ko not_active Application Discontinuation
- 1996-05-30 EA EA199700452A patent/EA000924B1/ru not_active IP Right Cessation
- 1996-05-30 HU HU9900102A patent/HUP9900102A3/hu unknown
- 1996-05-30 CN CN96195931A patent/CN1202893A/zh active Pending
- 1996-05-30 SK SK1620-97A patent/SK162097A3/sk unknown
- 1996-05-30 CZ CZ973743A patent/CZ374397A3/cs unknown
- 1996-05-30 PL PL96323835A patent/PL323835A1/xx unknown
- 1996-05-30 NZ NZ309944A patent/NZ309944A/en unknown
- 1996-05-30 AT AT96917833T patent/ATE245150T1/de not_active IP Right Cessation
- 1996-05-30 EP EP96917833A patent/EP0832076B1/en not_active Expired - Lifetime
- 1996-05-30 JP JP8536579A patent/JPH11504651A/ja active Pending
- 1996-05-31 ZA ZA9604486A patent/ZA964486B/xx unknown
- 1996-06-14 TW TW085107183A patent/TW454007B/zh not_active IP Right Cessation
-
1997
- 1997-11-24 LT LT97-182A patent/LT4416B/lt not_active IP Right Cessation
- 1997-11-25 US US08/978,295 patent/US6114328A/en not_active Expired - Lifetime
- 1997-12-29 LV LVP-97-239A patent/LV12046B/en unknown
Also Published As
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CZ374397A3 (cs) | 1998-12-16 |
EP0832076A1 (en) | 1998-04-01 |
AU6024396A (en) | 1996-12-18 |
US6114328A (en) | 2000-09-05 |
ES2198483T3 (es) | 2004-02-01 |
HUP9900102A2 (hu) | 1999-05-28 |
LV12046A (lv) | 1998-05-20 |
AU723577B2 (en) | 2000-08-31 |
EA000924B1 (ru) | 2000-06-26 |
DE69629116T2 (de) | 2004-04-08 |
JPH11504651A (ja) | 1999-04-27 |
WO1996038426A1 (en) | 1996-12-05 |
LT4416B (lt) | 1998-12-28 |
SK162097A3 (en) | 1999-04-13 |
EA199700452A1 (ru) | 1998-10-29 |
KR19990022198A (ko) | 1999-03-25 |
SI9620071A (sl) | 1998-12-31 |
ATE245150T1 (de) | 2003-08-15 |
IL118262A0 (en) | 1996-09-12 |
EP0832076B1 (en) | 2003-07-16 |
CN1202893A (zh) | 1998-12-23 |
CA2222147A1 (en) | 1996-12-05 |
LT97182A (en) | 1998-07-27 |
LV12046B (en) | 1998-09-20 |
NZ309944A (en) | 1999-10-28 |
IL118262A (en) | 2003-02-12 |
ZA964486B (en) | 1997-12-01 |
EE9700312A (et) | 1998-06-15 |
DE69629116D1 (de) | 2003-08-21 |
PL323835A1 (en) | 1998-04-27 |
HUP9900102A3 (en) | 2001-11-28 |
BR9609151A (pt) | 1999-06-29 |
TW454007B (en) | 2001-09-11 |
US5849736A (en) | 1998-12-15 |
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