HUP9900102A3 - Novel isoxazoline and isoxazole derivative fibrinogen receptor antagonists intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds as active ingredients - Google Patents
Novel isoxazoline and isoxazole derivative fibrinogen receptor antagonists intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds as active ingredientsInfo
- Publication number
- HUP9900102A3 HUP9900102A3 HU9900102A HUP9900102A HUP9900102A3 HU P9900102 A3 HUP9900102 A3 HU P9900102A3 HU 9900102 A HU9900102 A HU 9900102A HU P9900102 A HUP9900102 A HU P9900102A HU P9900102 A3 HUP9900102 A3 HU P9900102A3
- Authority
- HU
- Hungary
- Prior art keywords
- intermediates
- compounds
- preparation
- pharmaceutical compositions
- active ingredients
- Prior art date
Links
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002319 fibrinogen receptor antagonist Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000002545 isoxazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/455,436 US5849736A (en) | 1993-11-24 | 1995-05-31 | Isoxazoline and isoxazole fibrinogen receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9900102A2 HUP9900102A2 (hu) | 1999-05-28 |
HUP9900102A3 true HUP9900102A3 (en) | 2001-11-28 |
Family
ID=23808800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900102A HUP9900102A3 (en) | 1995-05-31 | 1996-05-30 | Novel isoxazoline and isoxazole derivative fibrinogen receptor antagonists intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds as active ingredients |
Country Status (26)
Country | Link |
---|---|
US (2) | US5849736A (hu) |
EP (1) | EP0832076B1 (hu) |
JP (1) | JPH11504651A (hu) |
KR (1) | KR19990022198A (hu) |
CN (1) | CN1202893A (hu) |
AT (1) | ATE245150T1 (hu) |
AU (1) | AU723577B2 (hu) |
BR (1) | BR9609151A (hu) |
CA (1) | CA2222147A1 (hu) |
CZ (1) | CZ374397A3 (hu) |
DE (1) | DE69629116T2 (hu) |
EA (1) | EA000924B1 (hu) |
EE (1) | EE9700312A (hu) |
ES (1) | ES2198483T3 (hu) |
HU (1) | HUP9900102A3 (hu) |
IL (1) | IL118262A (hu) |
LT (1) | LT4416B (hu) |
LV (1) | LV12046B (hu) |
NZ (1) | NZ309944A (hu) |
PL (1) | PL323835A1 (hu) |
RO (1) | RO117324B1 (hu) |
SI (1) | SI9620071A (hu) |
SK (1) | SK162097A3 (hu) |
TW (1) | TW454007B (hu) |
WO (1) | WO1996038426A1 (hu) |
ZA (1) | ZA964486B (hu) |
Families Citing this family (74)
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DE69633245T2 (de) * | 1995-09-29 | 2005-09-08 | Eli Lilly And Co., Indianapolis | Spiroverbindungen als Inhibitoren der Fibrinogen-abhängigen Blutplättchenaggregation |
US6004955A (en) * | 1996-08-15 | 1999-12-21 | Dupont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists |
DE69720773T2 (de) * | 1996-12-23 | 2004-01-29 | Bristol Myers Squibb Pharma Co | SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER |
US6187797B1 (en) | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
US6022977A (en) * | 1997-03-26 | 2000-02-08 | Dupont Pharmaceuticals Company | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids |
WO1998043962A1 (en) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
WO1998056408A2 (en) * | 1997-06-10 | 1998-12-17 | Regents Of The University Of Minnesota | Inhibitors of microbial adherence or invasion as therapeutic agents and broad-spectrum enhancers of antibiotic therapy |
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US5998424A (en) | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
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ZA988735B (en) * | 1997-10-06 | 2000-03-23 | Du Pont Pharm Co | An efficient method for the conversion of nitriles to amidines. |
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CN111323570B (zh) * | 2020-03-25 | 2021-11-05 | 天津市宝坻区人民医院 | 基于血栓弹力图的阿司匹林药物抵抗检测方法 |
WO2023019244A1 (en) * | 2021-08-13 | 2023-02-16 | Lapix Therapeutics, Inc. | Compositions and methods for reducing immune intolerance and treating autoimmune disorders |
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-
1995
- 1995-05-31 US US08/455,436 patent/US5849736A/en not_active Expired - Lifetime
-
1996
- 1996-05-15 IL IL11826296A patent/IL118262A/xx not_active IP Right Cessation
- 1996-05-30 CA CA002222147A patent/CA2222147A1/en not_active Abandoned
- 1996-05-30 JP JP8536579A patent/JPH11504651A/ja active Pending
- 1996-05-30 CZ CZ973743A patent/CZ374397A3/cs unknown
- 1996-05-30 CN CN96195931A patent/CN1202893A/zh active Pending
- 1996-05-30 EE EE9700312A patent/EE9700312A/xx unknown
- 1996-05-30 AU AU60243/96A patent/AU723577B2/en not_active Ceased
- 1996-05-30 EA EA199700452A patent/EA000924B1/ru not_active IP Right Cessation
- 1996-05-30 NZ NZ309944A patent/NZ309944A/en unknown
- 1996-05-30 EP EP96917833A patent/EP0832076B1/en not_active Expired - Lifetime
- 1996-05-30 HU HU9900102A patent/HUP9900102A3/hu unknown
- 1996-05-30 AT AT96917833T patent/ATE245150T1/de not_active IP Right Cessation
- 1996-05-30 BR BR9609151A patent/BR9609151A/pt unknown
- 1996-05-30 ES ES96917833T patent/ES2198483T3/es not_active Expired - Lifetime
- 1996-05-30 WO PCT/US1996/007692 patent/WO1996038426A1/en not_active Application Discontinuation
- 1996-05-30 RO RO97-02195A patent/RO117324B1/ro unknown
- 1996-05-30 PL PL96323835A patent/PL323835A1/xx unknown
- 1996-05-30 KR KR1019970708677A patent/KR19990022198A/ko not_active Application Discontinuation
- 1996-05-30 SK SK1620-97A patent/SK162097A3/sk unknown
- 1996-05-30 DE DE69629116T patent/DE69629116T2/de not_active Expired - Fee Related
- 1996-05-30 SI SI9620071A patent/SI9620071A/sl unknown
- 1996-05-31 ZA ZA9604486A patent/ZA964486B/xx unknown
- 1996-06-14 TW TW085107183A patent/TW454007B/zh not_active IP Right Cessation
-
1997
- 1997-11-24 LT LT97-182A patent/LT4416B/lt not_active IP Right Cessation
- 1997-11-25 US US08/978,295 patent/US6114328A/en not_active Expired - Lifetime
- 1997-12-29 LV LVP-97-239A patent/LV12046B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ309944A (en) | 1999-10-28 |
CZ374397A3 (cs) | 1998-12-16 |
AU6024396A (en) | 1996-12-18 |
WO1996038426A1 (en) | 1996-12-05 |
RO117324B1 (ro) | 2002-01-30 |
HUP9900102A2 (hu) | 1999-05-28 |
LV12046A (lv) | 1998-05-20 |
TW454007B (en) | 2001-09-11 |
CA2222147A1 (en) | 1996-12-05 |
BR9609151A (pt) | 1999-06-29 |
SI9620071A (sl) | 1998-12-31 |
ATE245150T1 (de) | 2003-08-15 |
PL323835A1 (en) | 1998-04-27 |
US6114328A (en) | 2000-09-05 |
KR19990022198A (ko) | 1999-03-25 |
LT97182A (en) | 1998-07-27 |
ES2198483T3 (es) | 2004-02-01 |
DE69629116T2 (de) | 2004-04-08 |
IL118262A (en) | 2003-02-12 |
LT4416B (lt) | 1998-12-28 |
EP0832076A1 (en) | 1998-04-01 |
DE69629116D1 (de) | 2003-08-21 |
EE9700312A (et) | 1998-06-15 |
IL118262A0 (en) | 1996-09-12 |
AU723577B2 (en) | 2000-08-31 |
ZA964486B (en) | 1997-12-01 |
JPH11504651A (ja) | 1999-04-27 |
CN1202893A (zh) | 1998-12-23 |
LV12046B (en) | 1998-09-20 |
US5849736A (en) | 1998-12-15 |
EP0832076B1 (en) | 2003-07-16 |
EA199700452A1 (ru) | 1998-10-29 |
EA000924B1 (ru) | 2000-06-26 |
SK162097A3 (en) | 1999-04-13 |
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