ATE259803T1 - 4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendung - Google Patents
4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendungInfo
- Publication number
- ATE259803T1 ATE259803T1 AT99953847T AT99953847T ATE259803T1 AT E259803 T1 ATE259803 T1 AT E259803T1 AT 99953847 T AT99953847 T AT 99953847T AT 99953847 T AT99953847 T AT 99953847T AT E259803 T1 ATE259803 T1 AT E259803T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- het
- optionally substituted
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98203394 | 1998-10-09 | ||
PCT/EP1999/007803 WO2000021959A1 (en) | 1998-10-09 | 1999-10-07 | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE259803T1 true ATE259803T1 (de) | 2004-03-15 |
Family
ID=8234198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99953847T ATE259803T1 (de) | 1998-10-09 | 1999-10-07 | 4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendung |
Country Status (10)
Country | Link |
---|---|
US (2) | US6583141B1 (de) |
EP (1) | EP1119568B1 (de) |
JP (1) | JP2002527438A (de) |
AT (1) | ATE259803T1 (de) |
AU (1) | AU763460B2 (de) |
CA (1) | CA2346396C (de) |
DE (1) | DE69914931T2 (de) |
ES (1) | ES2216579T3 (de) |
HK (1) | HK1038565A1 (de) |
WO (1) | WO2000021959A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69929345T2 (de) * | 1998-08-07 | 2006-09-21 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Substituierte isoxal-derivate als östrogenrezeptormodulatoren |
GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
CZ20032515A3 (cs) * | 2001-02-21 | 2003-12-17 | Janssen Pharmaceutica N. V. | Isoxazolinové deriváty jako anti-depresivní činidla |
JP4535680B2 (ja) | 2001-04-16 | 2010-09-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規1h−インダゾール化合物 |
JPWO2003068239A1 (ja) * | 2002-02-12 | 2005-06-02 | 住友製薬株式会社 | 新規外用剤 |
AR040126A1 (es) | 2002-05-29 | 2005-03-16 | Glaxo Group Ltd | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento |
TW200420573A (en) * | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
DK2910551T3 (en) | 2003-04-11 | 2017-05-15 | Ptc Therapeutics Inc | 1,2,4-oxadiazole benzoic acid compounds and their use in nonsense suppression and the treatment of disease |
WO2005034952A2 (en) * | 2003-10-07 | 2005-04-21 | The Feinstein Institute For Medical Research | Isoxazole and isothiazole compounds useful in the treatment of inflammation |
EP1632494A1 (de) | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonisten |
UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
BRPI0515488A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
CA2580845A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
EP2269610A3 (de) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren |
CN101083985A (zh) * | 2004-09-21 | 2007-12-05 | 幸讬制药公司 | 用于炎症及免疫相关用途的化合物 |
CA2587678C (en) * | 2004-11-16 | 2013-05-21 | Janssen Pharmaceutica N.V. | Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) |
JP2009513563A (ja) | 2005-06-03 | 2009-04-02 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトのステアロイル−CoAデサチュラーゼ阻害剤としてのアミノチアゾール誘導体 |
AU2007235524B2 (en) | 2006-03-30 | 2013-09-12 | Ptc Therapeutics, Inc. | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith |
PT2488486T (pt) * | 2009-10-13 | 2019-11-05 | Ligand Pharm Inc | Compostos de moléculas pequenas de mimética de fator de crescimento hematopoiético e utilizações dos mesmos |
ES2603032T3 (es) | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas |
CA3174516A1 (en) | 2014-03-06 | 2015-09-11 | Ptc Therapeutics, Inc. | Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid |
MX2018005361A (es) | 2015-10-30 | 2018-06-07 | Ptc Therapeutics Inc | Metodos para tratar epilepsia. |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
MX2022007376A (es) | 2019-12-20 | 2022-09-02 | Tenaya Therapeutics Inc | Fluoroalqull-oxadiazoles y sus usos. |
CN111592522B (zh) * | 2020-06-17 | 2022-09-09 | 郑州大学 | 一种精氨酸甲基化转移酶5小分子抑制剂及其制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5330994A (en) * | 1992-03-24 | 1994-07-19 | Warner-Lambert Company | Tetrahydropyridine isoxazoline derivatives |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
WO1995014680A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | 3-aryl-2-isoxazolines as antiinflammatory agents |
EP0749428B1 (de) * | 1994-03-09 | 1998-07-29 | Pfizer Inc. | Isoxazoline verbindung zur hemmung tnf-freigabe |
DE4408084A1 (de) | 1994-03-10 | 1995-09-14 | Hoechst Ag | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CA2240946C (en) * | 1995-12-21 | 2002-09-10 | The Dupont Merck Pharmaceutical Company | Isoxazoline, isothiazoline and pyrazoline factor xa inhibitors |
-
1999
- 1999-10-07 ES ES99953847T patent/ES2216579T3/es not_active Expired - Lifetime
- 1999-10-07 CA CA002346396A patent/CA2346396C/en not_active Expired - Fee Related
- 1999-10-07 US US09/807,149 patent/US6583141B1/en not_active Expired - Fee Related
- 1999-10-07 DE DE69914931T patent/DE69914931T2/de not_active Expired - Fee Related
- 1999-10-07 AU AU10393/00A patent/AU763460B2/en not_active Ceased
- 1999-10-07 AT AT99953847T patent/ATE259803T1/de not_active IP Right Cessation
- 1999-10-07 WO PCT/EP1999/007803 patent/WO2000021959A1/en active IP Right Grant
- 1999-10-07 EP EP99953847A patent/EP1119568B1/de not_active Expired - Lifetime
- 1999-10-07 JP JP2000575865A patent/JP2002527438A/ja active Pending
-
2002
- 2002-01-15 HK HK02100274A patent/HK1038565A1/xx not_active IP Right Cessation
-
2003
- 2003-03-31 US US10/403,543 patent/US7414048B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2346396A1 (en) | 2000-04-20 |
AU1039300A (en) | 2000-05-01 |
DE69914931T2 (de) | 2004-12-16 |
EP1119568A1 (de) | 2001-08-01 |
US6583141B1 (en) | 2003-06-24 |
AU763460B2 (en) | 2003-07-24 |
HK1038565A1 (en) | 2002-03-22 |
US7414048B2 (en) | 2008-08-19 |
JP2002527438A (ja) | 2002-08-27 |
WO2000021959A1 (en) | 2000-04-20 |
EP1119568B1 (de) | 2004-02-18 |
US20040019059A1 (en) | 2004-01-29 |
DE69914931D1 (de) | 2004-03-25 |
CA2346396C (en) | 2009-04-28 |
ES2216579T3 (es) | 2004-10-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE259803T1 (de) | 4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendung | |
DK1533292T3 (da) | Dibenzylaminforbindelse og medicinsk anvendelse deraf | |
NO20004485D0 (no) | Sykloalkenderivater, deres fremstilling og anvendelse | |
ATE220066T1 (de) | Benzimidazole derivate als cyclooxygenase-2 inhibitoren | |
HUP9701605A2 (hu) | Helyettesített bifenil- vagy fenil-piridin-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
JO2644B1 (en) | Derivatives of N- (amino-aryl mixture) -H1- indole-2-carboxamide Synthesis and therapeutic use | |
BG104248A (en) | Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides | |
TW200612920A (en) | Novel imidazolidine derivatives | |
HUP0201646A2 (hu) | Új alfa-aminosav vegyületek, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények | |
JP2005510476A5 (de) | ||
MA27651A1 (fr) | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases | |
HK1111999A1 (en) | Spiroketal derivative and use thereof as diabetic medicine | |
ZA200810739B (en) | Pesticide containing novel pyridyl-methanamine derivative or its salt | |
CA2167673A1 (en) | Condensed benzazepine derivative and pharmaceutical composition thereof | |
TW200635896A (en) | N-(heteroaryl)-1H-indole-2-carboxamide derivatives, preparation thereof and therapeutic application thereof | |
WO2008153042A1 (ja) | 抗腫瘍剤 | |
ATE305930T1 (de) | Substituierte benzopyran derivate gegen arrhythmie | |
ATE166055T1 (de) | 5h,10h-imidazo(1,2-a>indeno(1,2-e>pyrazin-4-one derivate, ihre herstellung und die sie enthaltenden arzneimittel | |
NZ221699A (en) | Pyridazinone derivatives; pharmaceutical compositions and intermediates | |
NO20071708L (no) | 4((2,4-diklor-5-metoksyfenyl) amino)-6-alkoksy-7-etynyl-3-kinolinkarbonitriler for behandling av ischemisk skade. | |
DE60104949D1 (de) | Heilmittel für diabetes welche 2-(n-cyanoimino)thiazolidine-4-one derivate enthalten | |
DE60144246D1 (de) | Imidazolderivate, verfahren zu deren herstellung und deren verwendung | |
JP2004518633A5 (de) | ||
WO2001044197A3 (fr) | Derives de 2-phenyl-quinoleine et leur utilisation en tant qu'agent contractant des muscles lisses | |
KR940018362A (ko) | 니코틴산 유도체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |