ATE305930T1 - Substituierte benzopyran derivate gegen arrhythmie - Google Patents

Substituierte benzopyran derivate gegen arrhythmie

Info

Publication number
ATE305930T1
ATE305930T1 AT02736131T AT02736131T ATE305930T1 AT E305930 T1 ATE305930 T1 AT E305930T1 AT 02736131 T AT02736131 T AT 02736131T AT 02736131 T AT02736131 T AT 02736131T AT E305930 T1 ATE305930 T1 AT E305930T1
Authority
AT
Austria
Prior art keywords
sup
sub
group
alkyl group
benzopyran derivatives
Prior art date
Application number
AT02736131T
Other languages
English (en)
Inventor
Yoshio Ohara
Kazuhiko Ohrai
Kazufumi Yanagihara
Yukihiro Shigeta
Toru Tsukagoshi
Toru Yamashita
Shiraoka Oaza
Original Assignee
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd
Application granted granted Critical
Publication of ATE305930T1 publication Critical patent/ATE305930T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02736131T 2001-06-25 2002-06-17 Substituierte benzopyran derivate gegen arrhythmie ATE305930T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001190594 2001-06-25
PCT/JP2002/006012 WO2003000675A1 (en) 2001-06-25 2002-06-17 Substituted benzopyran derivatives against arrhythmia

Publications (1)

Publication Number Publication Date
ATE305930T1 true ATE305930T1 (de) 2005-10-15

Family

ID=19029343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02736131T ATE305930T1 (de) 2001-06-25 2002-06-17 Substituierte benzopyran derivate gegen arrhythmie

Country Status (16)

Country Link
US (1) US7041700B2 (de)
EP (1) EP1401823B1 (de)
KR (1) KR100869897B1 (de)
CN (1) CN1279036C (de)
AT (1) ATE305930T1 (de)
CA (1) CA2450541A1 (de)
CZ (1) CZ20033469A3 (de)
DE (1) DE60206505T2 (de)
HU (1) HUP0400362A3 (de)
IL (2) IL159218A0 (de)
NO (1) NO20035774L (de)
NZ (1) NZ529916A (de)
RU (1) RU2291867C2 (de)
SK (1) SK15782003A3 (de)
UA (1) UA77189C2 (de)
WO (1) WO2003000675A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
TWI346112B (en) 2004-02-25 2011-08-01 Nissan Chemical Ind Ltd Benzopyran compound
US7647250B2 (en) * 2004-03-08 2010-01-12 Sap Ag Method and program product for event monitoring
CN1934116B (zh) 2004-03-23 2012-10-10 日产化学工业株式会社 用作抗心律失常剂的三环苯并吡喃化合物
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7714150B2 (en) 2005-04-12 2010-05-11 Solvay Pharmaceuticals Gmbh Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
RU2427368C1 (ru) * 2010-03-05 2011-08-27 Государственное образовательное учреждение высшего профессионального образования САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ ХИМИКО-ФАРМАЦЕВТИЧЕСКАЯ АКАДЕМИЯ Федерального агентства по здравоохранению и социальному развитию (ГОУ ВПО СПХФА Росздрава) Антиаритмическое средство на основе 4-метил-7,7'-этилендиокси-2н-1-дибензопиран-2,2'-диона
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (de) 2011-07-01 2018-04-28
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
JP2014533258A (ja) 2011-11-15 2014-12-11 ゼンション・リミテッドＸｅｎｔｉｏｎ Ｌｉｍｉｔｅｄ カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用
WO2013112932A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases

Family Cites Families (25)

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ES454888A1 (es) 1976-01-27 1978-05-01 Beecham Group Ltd Un procedimiento para la preparacion de nuevos cromados.
JPS5657785A (en) 1979-09-28 1981-05-20 Beecham Group Ltd Chromanol derivative* its manufacture and medicinal composition containing it
JPS5657786A (en) 1979-09-28 1981-05-20 Beecham Group Ltd Chromanol derivative* its manufacture and medicinal composition containing it
ZM7682A1 (en) 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
DE3364145D1 (de) 1982-04-08 1986-07-24 Beecham Group Plc Antihypertensive benzopyranols
GB8610911D0 (en) 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
DK691488A (da) 1987-12-14 1989-06-15 Beecham Group Plc Hidtil ukendte forbindelser
JP2876712B2 (ja) 1989-07-17 1999-03-31 日産化学工業株式会社 光学活性ピラノベンゾオキサジアゾール誘導体
US5097037A (en) 1989-07-17 1992-03-17 Nissan Chemical Industries, Ltd. Process for the optical resolution of pyranobenzoxadiazole compounds
US5095016A (en) * 1989-08-11 1992-03-10 Kaken Pharmaceutical Co., Ltd. Benzopyran compounds, processes for their production and pharmaceutical compositions
CA2077541C (en) 1990-03-21 1998-08-18 Eric N. Jacobsen Chiral catalysts and epoxidation reactions catalyzed thereby
US5276168A (en) 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
AU651105B2 (en) 1990-06-18 1994-07-14 E.R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
US5352814A (en) 1991-08-30 1994-10-04 Nissan Chemical Industries, Ltd. Asymmetric epoxidation reaction
JPH05301878A (ja) 1991-08-30 1993-11-16 Nissan Chem Ind Ltd 不斉エポキシ化反応
JP2734457B2 (ja) 1994-02-23 1998-03-30 日産化学工業株式会社 不斉エポキシ化反応
ES2156880T3 (es) 1994-02-23 2001-08-01 Nissan Chemical Ind Ltd Procedimiento de epoxidacion asimetrica utilizando complejos de manganeso opticamente activos.
EP0764159B1 (de) 1994-06-10 2000-08-09 Smithkline Beecham Plc C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel
US5679706A (en) 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
JP4129601B2 (ja) 1996-07-26 2008-08-06 日産化学工業株式会社 クロマン誘導体
DE19748469A1 (de) * 1997-11-03 1999-05-06 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
JPH11209366A (ja) 1998-01-23 1999-08-03 Nissan Chem Ind Ltd クロマン誘導体及び心不全治療薬
EP1109544A4 (de) 1998-09-01 2004-10-27 Bristol Myers Squibb Co Kaluim-kanal inhibitoren und verwendungsmethode
JP2001151767A (ja) 1999-09-17 2001-06-05 Nissan Chem Ind Ltd ベンゾピラン誘導体

Also Published As

Publication number Publication date
US20040152763A1 (en) 2004-08-05
CN1520406A (zh) 2004-08-11
HUP0400362A3 (en) 2007-05-29
HK1063785A1 (en) 2005-01-14
RU2291867C2 (ru) 2007-01-20
CZ20033469A3 (cs) 2004-04-14
KR100869897B1 (ko) 2008-11-24
EP1401823B1 (de) 2005-10-05
NO20035774L (no) 2004-02-25
DE60206505T2 (de) 2006-07-06
WO2003000675A1 (en) 2003-01-03
HUP0400362A2 (hu) 2004-08-30
SK15782003A3 (sk) 2004-05-04
CN1279036C (zh) 2006-10-11
KR20040018391A (ko) 2004-03-03
IL159218A0 (en) 2004-06-01
US7041700B2 (en) 2006-05-09
NZ529916A (en) 2005-04-29
UA77189C2 (en) 2006-11-15
CA2450541A1 (en) 2003-01-03
DE60206505D1 (de) 2006-02-16
EP1401823A1 (de) 2004-03-31
IL159218A (en) 2009-12-24
RU2004101964A (ru) 2005-03-27

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