DE60206505D1 - Substituierte benzopyran derivate gegen arrhythmie - Google Patents

Substituierte benzopyran derivate gegen arrhythmie

Info

Publication number
DE60206505D1
DE60206505D1 DE60206505T DE60206505T DE60206505D1 DE 60206505 D1 DE60206505 D1 DE 60206505D1 DE 60206505 T DE60206505 T DE 60206505T DE 60206505 T DE60206505 T DE 60206505T DE 60206505 D1 DE60206505 D1 DE 60206505D1
Authority
DE
Germany
Prior art keywords
sup
sub
group
alkyl group
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60206505T
Other languages
English (en)
Other versions
DE60206505T2 (de
Inventor
Yoshio Ohara
Kazuhiko Ohrai
Kazufumi Yanagihara
Yukihiro Shigeta
Toru Tsukagoshi
Toru Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Publication of DE60206505D1 publication Critical patent/DE60206505D1/de
Application granted granted Critical
Publication of DE60206505T2 publication Critical patent/DE60206505T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60206505T 2001-06-25 2002-06-17 Substituierte benzopyranderivate gegen arrhytmie Expired - Lifetime DE60206505T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001190594 2001-06-25
JP2001190594 2001-06-25
PCT/JP2002/006012 WO2003000675A1 (en) 2001-06-25 2002-06-17 Substituted benzopyran derivatives against arrhythmia

Publications (2)

Publication Number Publication Date
DE60206505D1 true DE60206505D1 (de) 2006-02-16
DE60206505T2 DE60206505T2 (de) 2006-07-06

Family

ID=19029343

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60206505T Expired - Lifetime DE60206505T2 (de) 2001-06-25 2002-06-17 Substituierte benzopyranderivate gegen arrhytmie

Country Status (17)

Country Link
US (1) US7041700B2 (de)
EP (1) EP1401823B1 (de)
KR (1) KR100869897B1 (de)
CN (1) CN1279036C (de)
AT (1) ATE305930T1 (de)
CA (1) CA2450541A1 (de)
CZ (1) CZ20033469A3 (de)
DE (1) DE60206505T2 (de)
HK (1) HK1063785A1 (de)
HU (1) HUP0400362A3 (de)
IL (2) IL159218A0 (de)
NO (1) NO20035774L (de)
NZ (1) NZ529916A (de)
RU (1) RU2291867C2 (de)
SK (1) SK15782003A3 (de)
UA (1) UA77189C2 (de)
WO (1) WO2003000675A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
TWI346112B (en) 2004-02-25 2011-08-01 Nissan Chemical Ind Ltd Benzopyran compound
US7647250B2 (en) * 2004-03-08 2010-01-12 Sap Ag Method and program product for event monitoring
AU2005223612B2 (en) 2004-03-23 2010-06-24 Nissan Chemical Industries, Ltd. Tricyclic benzopyran compound as anti-arrhythmic agents
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7714150B2 (en) * 2005-04-12 2010-05-11 Solvay Pharmaceuticals Gmbh Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (de) 2011-07-01 2018-04-28
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
WO2013072693A1 (en) 2011-11-15 2013-05-23 Xention Limited Thieno [2, 3 - c] pyrazoles for use as potassium channel inhibitors
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES454888A1 (es) 1976-01-27 1978-05-01 Beecham Group Ltd Un procedimiento para la preparacion de nuevos cromados.
JPS5657786A (en) 1979-09-28 1981-05-20 Beecham Group Ltd Chromanol derivative* its manufacture and medicinal composition containing it
JPS5657785A (en) 1979-09-28 1981-05-20 Beecham Group Ltd Chromanol derivative* its manufacture and medicinal composition containing it
ZM7682A1 (en) 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
EP0091748B1 (de) 1982-04-08 1986-06-18 Beecham Group Plc Blutdrucksenkende Benzopyranole
GB8610911D0 (en) 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
DK691488A (da) 1987-12-14 1989-06-15 Beecham Group Plc Hidtil ukendte forbindelser
US5097037A (en) 1989-07-17 1992-03-17 Nissan Chemical Industries, Ltd. Process for the optical resolution of pyranobenzoxadiazole compounds
JP2876712B2 (ja) 1989-07-17 1999-03-31 日産化学工業株式会社 光学活性ピラノベンゾオキサジアゾール誘導体
US5095016A (en) * 1989-08-11 1992-03-10 Kaken Pharmaceutical Co., Ltd. Benzopyran compounds, processes for their production and pharmaceutical compositions
ATE161538T1 (de) 1990-03-21 1998-01-15 Res Corp Technologies Inc Chirale katalysatoren und dadurch katalysierte epoxydierungsreaktionen
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
AU651105B2 (en) * 1990-06-18 1994-07-14 E.R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
JPH05301878A (ja) 1991-08-30 1993-11-16 Nissan Chem Ind Ltd 不斉エポキシ化反応
US5352814A (en) 1991-08-30 1994-10-04 Nissan Chemical Industries, Ltd. Asymmetric epoxidation reaction
JP2734457B2 (ja) 1994-02-23 1998-03-30 日産化学工業株式会社 不斉エポキシ化反応
EP0669339B1 (de) * 1994-02-23 2001-05-23 Nissan Chemical Industries Ltd. Asymmetrisches Epoxidationsverfahren unter Verwendung von optisch-aktiven Mangankomplexen
DE69518322T2 (de) 1994-06-10 2001-02-15 Smithkline Beecham Plc C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
JP4129601B2 (ja) 1996-07-26 2008-08-06 日産化学工業株式会社 クロマン誘導体
JPH11209366A (ja) 1998-01-23 1999-08-03 Nissan Chem Ind Ltd クロマン誘導体及び心不全治療薬
EP1109544A4 (de) * 1998-09-01 2004-10-27 Bristol Myers Squibb Co Kaluim-kanal inhibitoren und verwendungsmethode
JP2001151767A (ja) 1999-09-17 2001-06-05 Nissan Chem Ind Ltd ベンゾピラン誘導体

Also Published As

Publication number Publication date
WO2003000675A1 (en) 2003-01-03
KR100869897B1 (ko) 2008-11-24
UA77189C2 (en) 2006-11-15
NO20035774L (no) 2004-02-25
IL159218A (en) 2009-12-24
SK15782003A3 (sk) 2004-05-04
IL159218A0 (en) 2004-06-01
ATE305930T1 (de) 2005-10-15
CA2450541A1 (en) 2003-01-03
US20040152763A1 (en) 2004-08-05
CZ20033469A3 (cs) 2004-04-14
KR20040018391A (ko) 2004-03-03
EP1401823B1 (de) 2005-10-05
RU2291867C2 (ru) 2007-01-20
US7041700B2 (en) 2006-05-09
HUP0400362A2 (hu) 2004-08-30
HUP0400362A3 (en) 2007-05-29
EP1401823A1 (de) 2004-03-31
CN1520406A (zh) 2004-08-11
HK1063785A1 (en) 2005-01-14
CN1279036C (zh) 2006-10-11
NZ529916A (en) 2005-04-29
DE60206505T2 (de) 2006-07-06
RU2004101964A (ru) 2005-03-27

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