RO113346B1 - Derivati de 1h-imidazol si procedee pentru prepararea acestora - Google Patents

Derivati de 1h-imidazol si procedee pentru prepararea acestora Download PDF

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Publication number
RO113346B1
RO113346B1 RO95-02138A RO9502138A RO113346B1 RO 113346 B1 RO113346 B1 RO 113346B1 RO 9502138 A RO9502138 A RO 9502138A RO 113346 B1 RO113346 B1 RO 113346B1
Authority
RO
Romania
Prior art keywords
formula
compound
imidazole
tetrahydro
alkyl
Prior art date
Application number
RO95-02138A
Other languages
English (en)
Romanian (ro)
Inventor
Jean-Pierre Gerrts
Genevieve Motte
Edmond Differding
Jean-Pierre Henichart
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of RO113346B1 publication Critical patent/RO113346B1/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RO95-02138A 1994-12-14 1995-12-08 Derivati de 1h-imidazol si procedee pentru prepararea acestora RO113346B1 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
RO113346B1 true RO113346B1 (ro) 1998-06-30

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
RO95-02138A RO113346B1 (ro) 1994-12-14 1995-12-08 Derivati de 1h-imidazol si procedee pentru prepararea acestora

Country Status (26)

Country Link
US (1) US5658938A (en:Method)
EP (1) EP0717037A1 (en:Method)
JP (1) JPH08208622A (en:Method)
KR (1) KR960022474A (en:Method)
CN (1) CN1054376C (en:Method)
AR (1) AR002257A1 (en:Method)
AU (1) AU693614B2 (en:Method)
BG (1) BG63043B1 (en:Method)
BR (1) BR9505815A (en:Method)
CA (1) CA2165133A1 (en:Method)
CZ (1) CZ327195A3 (en:Method)
EE (1) EE9500064A (en:Method)
FI (1) FI955927A7 (en:Method)
GB (1) GB9425211D0 (en:Method)
HU (1) HUT73980A (en:Method)
IL (1) IL116325A (en:Method)
IS (1) IS4311A (en:Method)
MX (1) MX9505063A (en:Method)
NO (1) NO305316B1 (en:Method)
NZ (1) NZ280646A (en:Method)
PL (1) PL311736A1 (en:Method)
RO (1) RO113346B1 (en:Method)
RU (1) RU2156239C2 (en:Method)
SK (1) SK155095A3 (en:Method)
TW (1) TW303362B (en:Method)
ZA (1) ZA9510554B (en:Method)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
ZA981080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US6503935B1 (en) * 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
PT1280779E (pt) 2000-05-08 2005-11-30 Orion Corp Novos indanilimidazois policiclicos com actividade adrenergica alfa2
TW200306783A (en) * 2002-04-29 2003-12-01 Fmc Corp Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
BRPI0707258A2 (pt) * 2005-01-27 2011-04-26 Hoffmann La Roche uso de 2-imidazóis para o tratamento de distúrbios de cns
DE602007005671D1 (de) * 2006-10-19 2010-05-12 Hoffmann La Roche Aminomethyl-2-imidazole mit affinität zu mit dem trace-amin assoziierten rezeptoren
JP5335681B2 (ja) * 2006-10-19 2013-11-06 エフ．ホフマン−ラ ロシュ アーゲー アミノメチル−４−イミダゾール
WO2008052907A1 (en) * 2006-11-02 2008-05-08 F. Hoffmann-La Roche Ag Substituted 2-imidazoles as modulators of the trace amine associated receptors
WO2008058867A2 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
EP2101762B1 (en) * 2006-12-13 2011-05-18 F. Hoffmann-La Roche AG Novel 2 -imidazoles as ligands for trace amine associated receptors (taar)
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
CA2675221C (en) 2007-02-02 2016-02-23 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as taar1 ligands
EP2125749A2 (en) * 2007-02-13 2009-12-02 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
JP2010518163A (ja) * 2007-02-13 2010-05-27 シェーリング コーポレイション 機能選択性α２Ｃアドレナリン受容体アゴニスト
JP2010518161A (ja) * 2007-02-13 2010-05-27 シェーリング コーポレイション 機能選択性α２Ｃアドレナリン受容体アゴニストとしてのクロマン誘導体および類似体
CA2676944C (en) * 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
BRPI0812840A2 (pt) 2007-07-02 2014-12-09 Hoffmann La Roche 2-imidazolinas
CA2691704A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
CA2694362A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
AU2008281877A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of CNS disorders
CN101784515A (zh) * 2007-08-03 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
WO2009105504A2 (en) 2008-02-21 2009-08-27 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
ES2556633T3 (es) * 2008-07-24 2016-01-19 F. Hoffmann-La Roche Ag Derivados de 4,5-dihidro-oxazol-2-ilo
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
WO2010042473A1 (en) 2008-10-07 2010-04-15 Schering Corporation Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
KR101631003B1 (ko) 2012-01-12 2016-06-15 에프. 호프만-라 로슈 아게 미량 아민 결합 수용체(taar)로서 헤테로환형 유도체
SI2895477T1 (en) 2012-09-14 2018-02-28 F. Hoffmann-La Roche Ag Derivatives of pyrazole carboxamide as TAAR modulators for use in the treatment of multiple forms of disorders, such as depression, diabetes, and Parkinson's disease
EP2895478B1 (en) * 2012-09-17 2016-10-19 F. Hoffmann-La Roche AG Triazole carboxamide derivatives
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
WO2016030310A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted azetidine derivatives as taar ligands
WO2016030306A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
UA126377C2 (uk) * 2016-03-17 2022-09-28 Фмк Корпорейшн Спосіб перетворення s-енантіомера в його рацемічну форму
HUE050986T2 (hu) 2016-03-17 2021-01-28 Hoffmann La Roche 5-etil-4-metil-pirazol-3-karboxamid származék, amely TAAR-agonista aktivitású
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6048972A (ja) * 1983-08-25 1985-03-16 Dai Ichi Seiyaku Co Ltd テトラヒドロナフタレン誘導体
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5151526A (en) * 1990-10-11 1992-09-29 The United States Of America As Represented By The Secretary Of The Army 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic
JPH04210680A (ja) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd イミダゾール誘導体および植物生長調節剤
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles

Also Published As

Publication number Publication date
TW303362B (en:Method) 1997-04-21
NZ280646A (en) 1996-08-27
AU693614B2 (en) 1998-07-02
RU2156239C2 (ru) 2000-09-20
FI955927L (fi) 1996-06-15
CZ327195A3 (en) 1996-07-17
NO955034L (no) 1996-06-17
US5658938A (en) 1997-08-19
GB9425211D0 (en) 1995-02-15
IL116325A (en) 1999-10-28
FI955927A7 (fi) 1996-06-15
AR002257A1 (es) 1998-03-11
CA2165133A1 (en) 1996-06-15
CN1133837A (zh) 1996-10-23
HUT73980A (en) 1996-10-28
BG63043B1 (bg) 2001-02-28
MX9505063A (es) 1997-01-31
IL116325A0 (en) 1996-03-31
CN1054376C (zh) 2000-07-12
FI955927A0 (fi) 1995-12-11
EE9500064A (et) 1996-06-17
BR9505815A (pt) 1998-01-06
NO955034D0 (no) 1995-12-12
KR960022474A (ko) 1996-07-18
ZA9510554B (en) 1996-06-13
EP0717037A1 (fr) 1996-06-19
NO305316B1 (no) 1999-05-10
BG100208A (bg) 1996-07-31
AU4036895A (en) 1996-06-20
HU9503549D0 (en) 1996-02-28
IS4311A (is) 1996-06-15
SK155095A3 (en) 1997-02-05
JPH08208622A (ja) 1996-08-13
PL311736A1 (en) 1996-06-24

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