PT95911B - Processo para preparacao de vectores geneticos da expressao do factor de crescimento dos nervos em celulas eucarioticas - Google Patents

Processo para preparacao de vectores geneticos da expressao do factor de crescimento dos nervos em celulas eucarioticas Download PDF

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Publication number
PT95911B
PT95911B PT95911A PT9591190A PT95911B PT 95911 B PT95911 B PT 95911B PT 95911 A PT95911 A PT 95911A PT 9591190 A PT9591190 A PT 9591190A PT 95911 B PT95911 B PT 95911B
Authority
PT
Portugal
Prior art keywords
human
vector
cells
promoter
gene
Prior art date
Application number
PT95911A
Other languages
English (en)
Portuguese (pt)
Other versions
PT95911A (pt
Inventor
Francesco Della Valle
Lanfranco Callegaro
Alessandro Negro
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of PT95911A publication Critical patent/PT95911A/pt
Publication of PT95911B publication Critical patent/PT95911B/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT95911A 1989-11-16 1990-11-15 Processo para preparacao de vectores geneticos da expressao do factor de crescimento dos nervos em celulas eucarioticas PT95911B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Publications (2)

Publication Number Publication Date
PT95911A PT95911A (pt) 1991-09-13
PT95911B true PT95911B (pt) 1998-01-30

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95911A PT95911B (pt) 1989-11-16 1990-11-15 Processo para preparacao de vectores geneticos da expressao do factor de crescimento dos nervos em celulas eucarioticas

Country Status (22)

Country Link
US (1) US5457034A (https=)
EP (1) EP0432510B1 (https=)
JP (2) JP3121611B2 (https=)
KR (1) KR910009929A (https=)
CN (1) CN1051934A (https=)
AR (1) AR246983A1 (https=)
AT (1) ATE214735T1 (https=)
CA (1) CA2030108C (https=)
DE (1) DE69033937T2 (https=)
ES (1) ES2173856T3 (https=)
FI (1) FI905691A7 (https=)
HU (1) HUT61047A (https=)
IE (1) IE904120A1 (https=)
IL (1) IL96347A (https=)
IT (1) IT1238348B (https=)
NZ (1) NZ236058A (https=)
PE (1) PE28191A1 (https=)
PL (1) PL287811A1 (https=)
PT (1) PT95911B (https=)
TW (1) TW205069B (https=)
YU (1) YU217890A (https=)
ZA (1) ZA909122B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
US6964947B1 (en) * 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
AU2001279073B2 (en) 2000-07-28 2006-08-24 Christopher J. Murphy Transplant media
AU2002339843B2 (en) * 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
CN101260398B (zh) * 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
CN104072606B (zh) * 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
MX358161B (es) 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
WO2023004784A1 (zh) * 2021-07-30 2023-02-02 成都优洛生物科技有限公司 一种重组cho细胞、其构建方法、利用其的检测系统和方法
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
PE28191A1 (es) 1991-10-28
HU907174D0 (en) 1991-05-28
HUT61047A (en) 1992-11-30
YU217890A (sh) 1993-05-28
IE904120A1 (en) 1991-05-22
CA2030108A1 (en) 1991-05-17
KR910009929A (ko) 1991-06-28
US5457034A (en) 1995-10-10
DE69033937D1 (de) 2002-04-25
JP2001000194A (ja) 2001-01-09
CA2030108C (en) 1998-04-28
AU6655890A (en) 1991-05-23
DE69033937T2 (de) 2002-11-14
PL287811A1 (en) 1991-12-02
IT8948564A0 (it) 1989-11-16
ZA909122B (en) 1991-09-25
FI905691A0 (fi) 1990-11-16
AR246983A1 (es) 1994-10-31
CN1051934A (zh) 1991-06-05
FI905691L (fi) 1991-05-17
IT1238348B (it) 1993-07-13
FI905691A7 (fi) 1991-05-17
PT95911A (pt) 1991-09-13
JPH03224490A (ja) 1991-10-03
EP0432510A1 (en) 1991-06-19
IT8948564A1 (it) 1991-05-16
TW205069B (https=) 1993-05-01
IL96347A0 (en) 1991-08-16
ES2173856T3 (es) 2002-11-01
IL96347A (en) 1997-11-20
JP3121611B2 (ja) 2001-01-09
ATE214735T1 (de) 2002-04-15
AU645998B2 (en) 1994-02-03
NZ236058A (en) 1993-04-28
EP0432510B1 (en) 2002-03-20

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Effective date: 19910405

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Effective date: 19971022