IT1238348B - Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. - Google Patents

Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Info

Publication number
IT1238348B
IT1238348B IT04856489A IT4856489A IT1238348B IT 1238348 B IT1238348 B IT 1238348B IT 04856489 A IT04856489 A IT 04856489A IT 4856489 A IT4856489 A IT 4856489A IT 1238348 B IT1238348 B IT 1238348B
Authority
IT
Italy
Prior art keywords
eucariot
buildings
genetic
expression
cells
Prior art date
Application number
IT04856489A
Other languages
English (en)
Other versions
IT8948564A0 (it
IT8948564A1 (it
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of IT8948564A0 publication Critical patent/IT8948564A0/it
Priority to IT04856489A priority Critical patent/IT1238348B/it
Priority to NZ236058A priority patent/NZ236058A/xx
Priority to AU66558/90A priority patent/AU645998C/en
Priority to IL96347A priority patent/IL96347A/xx
Priority to ZA909122A priority patent/ZA909122B/xx
Priority to CA002030108A priority patent/CA2030108C/en
Priority to PE1990177640A priority patent/PE28191A1/es
Priority to YU217890A priority patent/YU217890A/sh
Priority to IE412090A priority patent/IE904120A1/en
Priority to PT95911A priority patent/PT95911B/pt
Priority to DE69033937T priority patent/DE69033937T2/de
Priority to EP90121961A priority patent/EP0432510B1/en
Priority to PL28781190A priority patent/PL287811A1/xx
Priority to CN90109292A priority patent/CN1051934A/zh
Priority to HU907174A priority patent/HUT61047A/hu
Priority to FI905691A priority patent/FI905691A/fi
Priority to AT90121961T priority patent/ATE214735T1/de
Priority to ES90121961T priority patent/ES2173856T3/es
Priority to JP02312577A priority patent/JP3121611B2/ja
Priority to KR1019900018690A priority patent/KR910009929A/ko
Priority to AR90318408A priority patent/AR246983A1/es
Priority to TW079110979A priority patent/TW205069B/zh
Publication of IT8948564A1 publication Critical patent/IT8948564A1/it
Application granted granted Critical
Publication of IT1238348B publication Critical patent/IT1238348B/it
Priority to US08/156,792 priority patent/US5457034A/en
Priority to JP2000133485A priority patent/JP2001000194A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IT04856489A 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. IT1238348B (it)

Priority Applications (24)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.
NZ236058A NZ236058A (en) 1989-11-16 1990-11-13 Expression vector for hbeta-ngf (human beta nerve growth factor), product and composition
AU66558/90A AU645998C (en) 1989-11-16 1990-11-13 Process for the preparation of genetic vectors for the nerve growth factor expression in eukaryotic cells
IL96347A IL96347A (en) 1989-11-16 1990-11-14 Process for the preparation of genetic vectors for the nerve growth factor expression in eukaryotic cells
ZA909122A ZA909122B (en) 1989-11-16 1990-11-14 Process for the preparation of genetic vectors for the nerve growth factor expression in eukaryotic cells
CA002030108A CA2030108C (en) 1989-11-16 1990-11-15 Process for the preparation of genetic vectors for the expression of nerve growth factor in eukaryotic cells
PE1990177640A PE28191A1 (es) 1989-11-16 1990-11-15 Procedimiento para la expresion del factor de crecimiento nervioso en celulas eucarioticas
YU217890A YU217890A (sh) 1989-11-16 1990-11-15 Postupak za dobijanje genetskih konstrukcija za ekspresiju nervnog faktora rasta u eukariotskim ćelijama
IE412090A IE904120A1 (en) 1989-11-16 1990-11-15 Process for the preparation of genetic vectors for the nerve¹growth factor expression in eukaryotic cells
PT95911A PT95911B (pt) 1989-11-16 1990-11-15 Processo para preparacao de vectores geneticos da expressao do factor de crescimento dos nervos em celulas eucarioticas
PL28781190A PL287811A1 (en) 1989-11-16 1990-11-16 Method of obtaining a vector encoding the nerve growth factor of a nerve subject to expression in eucariotic cells and method of obtaining such nerve growth factor
KR1019900018690A KR910009929A (ko) 1989-11-16 1990-11-16 진핵세포에서 신경성장인자의 발현을 위한 유전자 구조의 제조방법
DE69033937T DE69033937T2 (de) 1989-11-16 1990-11-16 Verfahren zur Herstellung von genetischen Vektoren zur Expression vom Nerven-Wachstumsfaktor in eukaryotischen Zellen
CN90109292A CN1051934A (zh) 1989-11-16 1990-11-16 在真核细胞中表达神经生长因子的基因构建物的制备方法
HU907174A HUT61047A (en) 1989-11-16 1990-11-16 Process for producing genetic structures for the expression of nerve cell growth factor in eucaryotic cells
FI905691A FI905691A (fi) 1989-11-16 1990-11-16 Foerfarande foer framstaellning av genetiska vektorer foer expression av nervtillvaextfaktorn i eukaryotiska celler.
AT90121961T ATE214735T1 (de) 1989-11-16 1990-11-16 Verfahren zur herstellung von genetischen vektoren zur expression vom nerven- wachstumsfaktor in eukaryotischen zellen
ES90121961T ES2173856T3 (es) 1989-11-16 1990-11-16 Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas.
JP02312577A JP3121611B2 (ja) 1989-11-16 1990-11-16 神経成長因子を真核生物細胞において発現させるための遺伝子ベクター
EP90121961A EP0432510B1 (en) 1989-11-16 1990-11-16 Process for the preparation of genetic vectors for the nerve growth factor expression in eukaryotic cells
AR90318408A AR246983A1 (es) 1989-11-16 1990-11-19 Plasmido dna recombinante, linea celular y procedimiento para producir beta-ngf humano.
TW079110979A TW205069B (it) 1989-11-16 1990-12-28
US08/156,792 US5457034A (en) 1989-11-16 1993-11-24 Vectors for expression of NGF in eukaryotic cells
JP2000133485A JP2001000194A (ja) 1989-11-16 2000-05-02 神経成長因子を真核生物細胞において発現させるための遺伝子ベクター

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Publications (3)

Publication Number Publication Date
IT8948564A0 IT8948564A0 (it) 1989-11-16
IT8948564A1 IT8948564A1 (it) 1991-05-16
IT1238348B true IT1238348B (it) 1993-07-13

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Country Status (22)

Country Link
US (1) US5457034A (it)
EP (1) EP0432510B1 (it)
JP (2) JP3121611B2 (it)
KR (1) KR910009929A (it)
CN (1) CN1051934A (it)
AR (1) AR246983A1 (it)
AT (1) ATE214735T1 (it)
CA (1) CA2030108C (it)
DE (1) DE69033937T2 (it)
ES (1) ES2173856T3 (it)
FI (1) FI905691A (it)
HU (1) HUT61047A (it)
IE (1) IE904120A1 (it)
IL (1) IL96347A (it)
IT (1) IT1238348B (it)
NZ (1) NZ236058A (it)
PE (1) PE28191A1 (it)
PL (1) PL287811A1 (it)
PT (1) PT95911B (it)
TW (1) TW205069B (it)
YU (1) YU217890A (it)
ZA (1) ZA909122B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6964947B1 (en) 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
DE60040678D1 (en) 1999-09-29 2008-12-11 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
DE60139874D1 (de) * 2000-07-28 2009-10-22 Christopher J Murphy Medium für transplantat
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
WO2004093902A1 (en) 2003-03-19 2004-11-04 The General Hospital Corporation CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
US8143374B2 (en) * 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
CN101260398B (zh) * 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
AU2008282805B2 (en) * 2007-08-01 2014-05-01 Chugai Pharmaceutical Co., Ltd. Screening methods using G-protein coupled receptors and related compositions
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
EP2569003B1 (en) 2010-05-13 2017-10-25 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
CN114729330A (zh) * 2021-07-30 2022-07-08 成都优洛生物科技有限公司 一种重组cho细胞、其构建方法、利用其的检测系统和方法
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
IL96347A (en) 1997-11-20
HUT61047A (en) 1992-11-30
AU645998B2 (en) 1994-02-03
ATE214735T1 (de) 2002-04-15
CA2030108C (en) 1998-04-28
ES2173856T3 (es) 2002-11-01
PT95911A (pt) 1991-09-13
EP0432510B1 (en) 2002-03-20
IT8948564A0 (it) 1989-11-16
YU217890A (sh) 1993-05-28
FI905691A0 (fi) 1990-11-16
PT95911B (pt) 1998-01-30
FI905691A (fi) 1991-05-17
JP3121611B2 (ja) 2001-01-09
AR246983A1 (es) 1994-10-31
JP2001000194A (ja) 2001-01-09
DE69033937D1 (de) 2002-04-25
IL96347A0 (en) 1991-08-16
KR910009929A (ko) 1991-06-28
CN1051934A (zh) 1991-06-05
NZ236058A (en) 1993-04-28
DE69033937T2 (de) 2002-11-14
TW205069B (it) 1993-05-01
CA2030108A1 (en) 1991-05-17
US5457034A (en) 1995-10-10
PE28191A1 (es) 1991-10-28
AU6655890A (en) 1991-05-23
HU907174D0 (en) 1991-05-28
ZA909122B (en) 1991-09-25
IE904120A1 (en) 1991-05-22
PL287811A1 (en) 1991-12-02
EP0432510A1 (en) 1991-06-19
JPH03224490A (ja) 1991-10-03
IT8948564A1 (it) 1991-05-16

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950925