DE69033937D1 - Verfahren zur Herstellung von genetischen Vektoren zur Expression vom Nerven-Wachstumsfaktor in eukaryotischen Zellen - Google Patents

Verfahren zur Herstellung von genetischen Vektoren zur Expression vom Nerven-Wachstumsfaktor in eukaryotischen Zellen

Info

Publication number
DE69033937D1
DE69033937D1 DE69033937T DE69033937T DE69033937D1 DE 69033937 D1 DE69033937 D1 DE 69033937D1 DE 69033937 T DE69033937 T DE 69033937T DE 69033937 T DE69033937 T DE 69033937T DE 69033937 D1 DE69033937 D1 DE 69033937D1
Authority
DE
Germany
Prior art keywords
expression
production
growth factor
eukaryotic cells
nerve growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033937T
Other languages
English (en)
Other versions
DE69033937T2 (de
Inventor
Valle Francesco Della
Lanfranco Callegaro
Alessandro Negro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Publication of DE69033937D1 publication Critical patent/DE69033937D1/de
Application granted granted Critical
Publication of DE69033937T2 publication Critical patent/DE69033937T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69033937T 1989-11-16 1990-11-16 Verfahren zur Herstellung von genetischen Vektoren zur Expression vom Nerven-Wachstumsfaktor in eukaryotischen Zellen Expired - Fee Related DE69033937T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Publications (2)

Publication Number Publication Date
DE69033937D1 true DE69033937D1 (de) 2002-04-25
DE69033937T2 DE69033937T2 (de) 2002-11-14

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033937T Expired - Fee Related DE69033937T2 (de) 1989-11-16 1990-11-16 Verfahren zur Herstellung von genetischen Vektoren zur Expression vom Nerven-Wachstumsfaktor in eukaryotischen Zellen

Country Status (22)

Country Link
US (1) US5457034A (de)
EP (1) EP0432510B1 (de)
JP (2) JP3121611B2 (de)
KR (1) KR910009929A (de)
CN (1) CN1051934A (de)
AR (1) AR246983A1 (de)
AT (1) ATE214735T1 (de)
CA (1) CA2030108C (de)
DE (1) DE69033937T2 (de)
ES (1) ES2173856T3 (de)
FI (1) FI905691A (de)
HU (1) HUT61047A (de)
IE (1) IE904120A1 (de)
IL (1) IL96347A (de)
IT (1) IT1238348B (de)
NZ (1) NZ236058A (de)
PE (1) PE28191A1 (de)
PL (1) PL287811A1 (de)
PT (1) PT95911B (de)
TW (1) TW205069B (de)
YU (1) YU217890A (de)
ZA (1) ZA909122B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6964947B1 (en) * 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
US6495662B1 (en) * 1998-10-22 2002-12-17 The General Hospital Corporation Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
EP1305040B1 (de) * 2000-07-28 2009-09-09 Christopher J. Murphy Medium für transplantat
US7572765B2 (en) * 2001-07-23 2009-08-11 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
AU2003220380A1 (en) 2003-03-19 2004-11-19 Bristol-Myers Squibb Company CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS
EP1653985A4 (de) 2003-07-17 2009-08-05 Gen Hospital Corp Zwangsform-parathormon (pth)-analoga
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
US8143374B2 (en) * 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
CN101260398B (zh) 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
AU2008282805B2 (en) 2007-08-01 2014-05-01 Chugai Pharmaceutical Co., Ltd. Screening methods using G-protein coupled receptors and related compositions
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
CN103002906B (zh) 2010-05-13 2017-12-29 总医院有限公司 甲状旁腺激素类似物及其应用
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
WO2023004784A1 (zh) * 2021-07-30 2023-02-02 成都优洛生物科技有限公司 一种重组cho细胞、其构建方法、利用其的检测系统和方法
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
HU907174D0 (en) 1991-05-28
KR910009929A (ko) 1991-06-28
EP0432510A1 (de) 1991-06-19
PE28191A1 (es) 1991-10-28
IT1238348B (it) 1993-07-13
CN1051934A (zh) 1991-06-05
JPH03224490A (ja) 1991-10-03
IL96347A0 (en) 1991-08-16
NZ236058A (en) 1993-04-28
IT8948564A0 (it) 1989-11-16
JP3121611B2 (ja) 2001-01-09
TW205069B (de) 1993-05-01
ES2173856T3 (es) 2002-11-01
FI905691A0 (fi) 1990-11-16
DE69033937T2 (de) 2002-11-14
YU217890A (sh) 1993-05-28
IT8948564A1 (it) 1991-05-16
ATE214735T1 (de) 2002-04-15
IE904120A1 (en) 1991-05-22
IL96347A (en) 1997-11-20
ZA909122B (en) 1991-09-25
PL287811A1 (en) 1991-12-02
AU6655890A (en) 1991-05-23
PT95911B (pt) 1998-01-30
HUT61047A (en) 1992-11-30
US5457034A (en) 1995-10-10
EP0432510B1 (de) 2002-03-20
CA2030108A1 (en) 1991-05-17
AU645998B2 (en) 1994-02-03
AR246983A1 (es) 1994-10-31
PT95911A (pt) 1991-09-13
FI905691A (fi) 1991-05-17
JP2001000194A (ja) 2001-01-09
CA2030108C (en) 1998-04-28

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO

8339 Ceased/non-payment of the annual fee