ATE412670T1 - Parathyroid hormon (pth) polypeptidderivate - Google Patents
Parathyroid hormon (pth) polypeptidderivateInfo
- Publication number
- ATE412670T1 ATE412670T1 AT00910323T AT00910323T ATE412670T1 AT E412670 T1 ATE412670 T1 AT E412670T1 AT 00910323 T AT00910323 T AT 00910323T AT 00910323 T AT00910323 T AT 00910323T AT E412670 T1 ATE412670 T1 AT E412670T1
- Authority
- AT
- Austria
- Prior art keywords
- disclosed
- parathyroid hormone
- methods
- pth
- polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000003982 Parathyroid hormone Human genes 0.000 title abstract 4
- 108090000445 Parathyroid hormone Proteins 0.000 title abstract 4
- 239000000199 parathyroid hormone Substances 0.000 title abstract 4
- 229960001319 parathyroid hormone Drugs 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 abstract 1
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15692799P | 1999-09-29 | 1999-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412670T1 true ATE412670T1 (de) | 2008-11-15 |
Family
ID=22561687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00910323T ATE412670T1 (de) | 1999-09-29 | 2000-02-25 | Parathyroid hormon (pth) polypeptidderivate |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2030986A1 (de) |
| JP (1) | JP4723144B2 (de) |
| AT (1) | ATE412670T1 (de) |
| DE (1) | DE60040678D1 (de) |
| ES (1) | ES2316354T3 (de) |
| WO (1) | WO2001023427A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000031266A1 (en) | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Human parathyroid hormone modifications, preparation and use |
| WO2000032771A1 (en) | 1998-11-30 | 2000-06-08 | The General Hospital Corporation | Pth1r and pth3r receptors, methods and uses thereof |
| WO2000040698A1 (en) | 1998-12-31 | 2000-07-13 | The General Hospital Corporation | Pth receptor and screening assay utilizing the same |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| WO2003009804A2 (en) | 2001-07-23 | 2003-02-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| AU2003217243A1 (en) * | 2003-01-24 | 2004-08-23 | Thomas J. Gardella | Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges |
| MX353986B (es) | 2007-08-01 | 2017-11-06 | Massachusetts Gen Hospital | Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas. |
| FR2940292B1 (fr) * | 2008-12-23 | 2013-05-10 | Isp Investments Inc | Peptides derives d'hmg-coa reductase et composition cosmetique et/ou pharmaceutique les contenant |
| CN102448482A (zh) | 2009-03-27 | 2012-05-09 | 范安德尔研究所 | 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法 |
| JP5744844B2 (ja) * | 2009-04-24 | 2015-07-08 | カディラ ヘルスケア リミティド | 副甲状腺ホルモン（ｐｔｈ）受容体アゴニストとしての短鎖ペプチド |
| MX358161B (es) | 2010-05-13 | 2018-08-06 | The General Hospital Corp Star | Analogos de hormona paratiroidea y usos para los mismos. |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4512922A (en) | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4511502A (en) | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4620948A (en) | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4518526A (en) | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4736866A (en) | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
| IL78342A (en) | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| CA2045129A1 (en) | 1989-02-01 | 1990-08-02 | Alfred I. Geller | Herpes simplex virus type i expression vector |
| CA2045175C (en) | 1989-11-06 | 2003-03-18 | Arthur I. Skoultchi | Production of proteins using homologous recombination |
| IT1238348B (it) | 1989-11-16 | 1993-07-13 | Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. | |
| US5266490A (en) | 1991-03-28 | 1993-11-30 | Regeneron Pharmaceuticals, Inc. | Mammalian expression vector |
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US5871486A (en) | 1993-01-21 | 1999-02-16 | Acumed, Inc. | Variable pitch bone screw |
| CA2165162C (en) | 1993-06-14 | 2000-05-23 | Hermann Bujard | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5763416A (en) | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
| US5656465A (en) | 1994-05-04 | 1997-08-12 | Therion Biologics Corporation | Methods of in vivo gene delivery |
| US5714353A (en) | 1994-05-24 | 1998-02-03 | Research Corporation Technologies, Inc. | Safe vectors for gene therapy |
| US5836905A (en) | 1994-06-20 | 1998-11-17 | Lemelson; Jerome H. | Apparatus and methods for gene therapy |
| CA2178894A1 (en) * | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| JPH09157294A (ja) * | 1995-06-15 | 1997-06-17 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| US5723577A (en) | 1995-07-13 | 1998-03-03 | Biomeasure Inc. | Analogs of parathyroid hormone |
| US5917123A (en) | 1997-03-14 | 1999-06-29 | University Of Pittsburgh | Transgenic mice containing a nucleic acid encoding tumor necrosis factor-α under the control of a cardiac specific regulatory region |
| WO2000031266A1 (en) * | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Human parathyroid hormone modifications, preparation and use |
-
2000
- 2000-02-25 ES ES00910323T patent/ES2316354T3/es not_active Expired - Lifetime
- 2000-02-25 WO PCT/US2000/004716 patent/WO2001023427A1/en active Application Filing
- 2000-02-25 DE DE60040678T patent/DE60040678D1/de not_active Expired - Lifetime
- 2000-02-25 JP JP2001526577A patent/JP4723144B2/ja not_active Expired - Fee Related
- 2000-02-25 AT AT00910323T patent/ATE412670T1/de not_active IP Right Cessation
- 2000-02-25 EP EP08018788A patent/EP2030986A1/de not_active Withdrawn
- 2000-02-25 EP EP00910323A patent/EP1222208B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1222208B1 (de) | 2008-10-29 |
| WO2001023427A1 (en) | 2001-04-05 |
| EP1222208A1 (de) | 2002-07-17 |
| JP2003511014A (ja) | 2003-03-25 |
| DE60040678D1 (en) | 2008-12-11 |
| EP2030986A1 (de) | 2009-03-04 |
| ES2316354T3 (es) | 2009-04-16 |
| JP4723144B2 (ja) | 2011-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |