ES2180550T3 - Moleculas receptoras de la hormona de glycoproteina. - Google Patents

Moleculas receptoras de la hormona de glycoproteina.

Info

Publication number
ES2180550T3
ES2180550T3 ES94104166T ES94104166T ES2180550T3 ES 2180550 T3 ES2180550 T3 ES 2180550T3 ES 94104166 T ES94104166 T ES 94104166T ES 94104166 T ES94104166 T ES 94104166T ES 2180550 T3 ES2180550 T3 ES 2180550T3
Authority
ES
Spain
Prior art keywords
hormone receptor
receptor molecules
glycoprotein hormone
molecules
stimulating hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94104166T
Other languages
English (en)
Inventor
Karoly Nikolics
Keith C Mcfarland
Deborah L Segaloff
Peter H Seeburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2180550T3 publication Critical patent/ES2180550T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

EL INVENTO SE REFIERE A LA PURIFICACION, Y CLONACION DE RECEPTORES PARA LA HORMONA LUTEINIZANTE, CORIOGONADOTROPINA, HORMONA ESTIMULANTE DE FOLICULO, Y HORMONA ESTIMULANTE DE TIROIDES. EL INVENTO SE REFIERE ADICIONALMENTE A LOS EMPLEOS DE TALES MOLECULAS EN EL DIAGNOSTICO Y TERAPIA DE LAS CONDICIONES HUMANAS.
ES94104166T 1989-05-05 1990-05-04 Moleculas receptoras de la hormona de glycoproteina. Expired - Lifetime ES2180550T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34768389A 1989-05-05 1989-05-05

Publications (1)

Publication Number Publication Date
ES2180550T3 true ES2180550T3 (es) 2003-02-16

Family

ID=23364795

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94104166T Expired - Lifetime ES2180550T3 (es) 1989-05-05 1990-05-04 Moleculas receptoras de la hormona de glycoproteina.
ES90908349T Expired - Lifetime ES2068388T3 (es) 1989-05-05 1990-05-04 Moleculas de receptor de hormona de la glucoproteina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES90908349T Expired - Lifetime ES2068388T3 (es) 1989-05-05 1990-05-04 Moleculas de receptor de hormona de la glucoproteina.

Country Status (9)

Country Link
EP (3) EP1199361A3 (es)
JP (1) JPH04505103A (es)
AT (2) ATE221123T1 (es)
AU (1) AU5732190A (es)
DE (2) DE69015175T2 (es)
DK (2) DK0471030T3 (es)
ES (2) ES2180550T3 (es)
HK (1) HK1046429A1 (es)
WO (1) WO1990013643A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3181582B2 (ja) * 1989-09-08 2001-07-03 ニューイングランド・メディカル・センター・ホスピタルズ・インコーポレーテッド Ｔｓｈ受容体
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
ATE181746T1 (de) * 1990-09-10 1999-07-15 Takeda Chemical Industries Ltd Menschlicher rezeptor für luteinisierendes hormon und choriongonadotropin
WO1992016620A1 (en) * 1991-03-15 1992-10-01 Applied Research Systems Ars Holding N.V. Human follicle stimulating hormone receptor
AU3949893A (en) * 1992-03-30 1993-11-08 Akzo Nobel N.V. Human gonadotropin receptor (FSH receptor)
US6033903A (en) * 1995-06-02 2000-03-07 Applied Research Systems, ARS Holding N.V. Method of expressing and secreting soluble extracellular domains of human gonadotropin hormone receptors
AU2728297A (en) * 1996-04-15 1997-11-07 Board Of Trustees Of The Leland Stanford Junior University Soluble 7-transmembrane domain G-protein-coupled receptor compositions and me thods
US5858716A (en) 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
WO1999036530A2 (en) * 1998-01-20 1999-07-22 Wilex Biotechnology Gmbh Lh-receptor gene promoter for tissue-specific gene expression
GB9909661D0 (en) 1998-06-06 1999-06-23 Rsr Ltd Assays for TSH receptor autoantibodies
EP1456234B1 (en) 2001-08-23 2014-04-09 Rsr Limited Epitope regions of a thyrotrophin (tsh) receptor, uses thereof and antibodies thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560649A (en) * 1981-10-15 1985-12-24 Cornell Research Foundation Assaying for hLH or hCG with immobilized hormone receptors
US4761371A (en) * 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
US4921808A (en) * 1986-06-25 1990-05-01 The Albany Medical College Of Union University Method for determining follicle stimulating hormone
JP3181582B2 (ja) * 1989-09-08 2001-07-03 ニューイングランド・メディカル・センター・ホスピタルズ・インコーポレーテッド Ｔｓｈ受容体
EP0433509B1 (en) * 1989-12-14 1996-11-13 B.R.A.H.M.S Diagnostica GmbH Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
FR2657014A1 (fr) * 1990-01-15 1991-07-19 Inst Nat Sante Rech Med Recepteur humain de la tsh. sequence codant pour ce recepteur.

Also Published As

Publication number Publication date
DE69015175T2 (de) 1995-06-29
EP0471030B1 (en) 1994-12-14
DE69033990T2 (de) 2003-02-13
DE69033990D1 (de) 2002-08-29
ATE221123T1 (de) 2002-08-15
AU5732190A (en) 1990-11-29
EP1199361A2 (en) 2002-04-24
DK0471030T3 (da) 1995-05-29
EP0471030A1 (en) 1992-02-19
JPH04505103A (ja) 1992-09-10
ES2068388T3 (es) 1995-04-16
EP0614975B1 (en) 2002-07-24
ATE115409T1 (de) 1994-12-15
HK1046429A1 (zh) 2003-01-10
DK0614975T3 (da) 2002-11-11
WO1990013643A2 (en) 1990-11-15
EP0614975A1 (en) 1994-09-14
DE69015175D1 (de) 1995-01-26
EP1199361A3 (en) 2004-03-10
WO1990013643A3 (en) 1991-01-10

Similar Documents

Publication Publication Date Title
IE940809L (en) Ultrasonic contrast agents, process for their preparation¹and their use as diagnostic and therapeutic agents
FI851336A0 (fi) Ny fysiologiskt aktiv human polypeptid.
BG62870B1 (bg) Метод за получаване на човешка дезоксирибонуклеаза
GR880300077T1 (en) Galanthamine or analogues thereof for treating alzheimer's disease
ES2180550T3 (es) Moleculas receptoras de la hormona de glycoproteina.
DK143492A (da) Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet
DK0669979T3 (da) C-C CKR-1, kemokinreceptor
EP0786995A4 (es)
ZA896558B (en) Method of treating skin injuries using thromboxane a2 receptor antagonists
ATE199167T1 (de) Nichtglykosyliertes fgf-4 und dieses enthaltende präparate
ES2059545T3 (es) Hormonas de glicoproteinas modificadas por mutagenesis dirigida por puntos y metodos de uso de tales hormonas.
EE05497B1 (et) Polüpeptiid, lahustuv CRAM-1 polüpeptiid, polünukleotiid ja antikeha
ATE107859T1 (de) Verwendung von antiprogestomimetika zur stimulierung des eisprungs.
DE3886517T2 (de) Menschlicher Prourokinase ähnliches Polypeptid.
ES2076141T3 (es) 5-aril-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
IT8620548A0 (it) Procedimento e dispositivo per la fabbricazione di prodotti in fibra di vetro, per esempio veli, feltri, filati e stoppini.
EP0153961A4 (en) RECOMBINANT SUBSTANCES AND METHODS OF PRODUCING PEPTIDE III ACTIVATING HUMAN CONNECTIVE TISSUE AND THE LIKE.
IT8619086A0 (it) Composizioni farmaceutiche comprendenti frammenti di acth per il trattamento terapeutico degli stati di shock e dell'insufficienza respiratoria e cardiocircolatoria.
王殿洪 et al. PURIFICATION AND CHARACTERIZATION OF INSULIN RECEPTORS FROM HUMAN PLACENTA
DK0741746T3 (da) Thymosin alpha 1-analoger
IT8804860A0 (it) Procedimento per il recupero di calore, con eventuale recupero od uso dell'umidita', ceduto direttamente o indirettamente dal corpo umano e dispositivo per la sua attuazione.
NO880831D0 (no) Rekombinant human vevsplasminogen-aktivatorblanding.
ATE98990T1 (de) Menschlicher prourokinase aehnliches polypeptid.