ES2059545T3 - Hormonas de glicoproteinas modificadas por mutagenesis dirigida por puntos y metodos de uso de tales hormonas. - Google Patents
Hormonas de glicoproteinas modificadas por mutagenesis dirigida por puntos y metodos de uso de tales hormonas.Info
- Publication number
- ES2059545T3 ES2059545T3 ES88312143T ES88312143T ES2059545T3 ES 2059545 T3 ES2059545 T3 ES 2059545T3 ES 88312143 T ES88312143 T ES 88312143T ES 88312143 T ES88312143 T ES 88312143T ES 2059545 T3 ES2059545 T3 ES 2059545T3
- Authority
- ES
- Spain
- Prior art keywords
- hormones
- glycoprotein hormones
- directed mutagenesis
- glycoprotein
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940088597 hormone Drugs 0.000 title abstract 7
- 239000005556 hormone Substances 0.000 title abstract 7
- 102000003886 Glycoproteins Human genes 0.000 title abstract 5
- 108090000288 Glycoproteins Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title 1
- 238000002703 mutagenesis Methods 0.000 title 1
- 231100000350 mutagenesis Toxicity 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003667 hormone antagonist Substances 0.000 abstract 1
- 150000002482 oligosaccharides Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002741 site-directed mutagenesis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE DESCRIBEN NUEVAS HORMONAS GLICOPROTEINAS CAPACES DE COMPARTIR CON HORMONAS NATURALES PARA LOS SITIOS DE UNION DEL RECEPTOR NORMAL PERO INCAPACES SUSTANCIALMENTE DE EFECTUAR ACTIVIDADES POST RECEPTOR. LAS HORMONAS GLICOPROTEICAS DE LA PRESENTE INVENCION TIENEN CADENAS DE OLEIGOSACARIDOS ELIMINADAS COMO PARA EFECTUAR DISMINUIR LA ACTIVIDAD BIOLOGICA MIENTRAS EL PLASMA (MEDIO - VIDA) REDUCE NO SIGNIFICATIVAMENTE, LAS MOLECULAS DE EFECTIVIFAFES ASI COMO AUMENTADOS COMO UN ANTAGONISTA COMPARADO CON LAS MOLECULAS PRODUCIDAS CONVENCIONALMENTE. LAS HORMONAS GLICOPROTEICAS PREFERIDAS SON OBTENIDAS POR UNTOGENESIS DE SITIO DIRECTO, PARA DEGLICOSILAR SELECTIVAMENTE LA PROTEINA. TAMBIEN SE DESCRIBEN TRATAMIENTOD TERAPEUTICOS QUE COMPRENDEN LA ADMINISTRACION DE HORMONAS GLICOPROTEICAS DE LA PRIMERA INVENCION COMO CON HORMONA ANTAGONISTA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/136,236 US5260421A (en) | 1987-12-21 | 1987-12-21 | Site-directed mutagenesis modified glycoprotein hormones |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2059545T3 true ES2059545T3 (es) | 1994-11-16 |
ES2059545T5 ES2059545T5 (es) | 2000-05-01 |
Family
ID=22471965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88312143T Expired - Lifetime ES2059545T5 (es) | 1987-12-21 | 1988-12-21 | Hormonas de glicoproteinas modificadas por mutagenesis dirigida por puntos y metodos de uso de tales hormonas. |
Country Status (9)
Country | Link |
---|---|
US (3) | US5260421A (es) |
EP (1) | EP0322226B2 (es) |
JP (1) | JP2525048B2 (es) |
AT (1) | ATE95424T1 (es) |
CA (1) | CA1341284C (es) |
DE (1) | DE3884776T3 (es) |
ES (1) | ES2059545T5 (es) |
GR (1) | GR3032307T3 (es) |
HK (1) | HK143395A (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260421A (en) * | 1987-12-21 | 1993-11-09 | Applied Research Systems Ars Holding N.V. | Site-directed mutagenesis modified glycoprotein hormones |
US5635475A (en) * | 1987-12-21 | 1997-06-03 | Applied Research Systems Ars Holding N.V. | Site-directed mutagenesis modified glycoprotein hormones and methods of use |
US5444167A (en) * | 1993-07-07 | 1995-08-22 | Wallac Oy | Variant luteinizing hormone encoding DNA |
EP0739352A1 (en) * | 1994-01-20 | 1996-10-30 | Akzo Nobel N.V. | New composition of glycoprotein isoforms having follicle stimulating activity |
US6238890B1 (en) * | 1994-02-18 | 2001-05-29 | Washington University | Single chain forms of the glycoprotein hormone quartet |
US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
US5580853A (en) * | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
WO1995032216A1 (en) * | 1994-05-25 | 1995-11-30 | University Of Nebraska Board Of Regents | Biologically active glycoprotein hormones produced in procaryotic cells |
FR2768627B1 (fr) * | 1997-09-19 | 2000-03-24 | Agronomique Inst Nat Rech | Medicament veterinaire contenant de la choriogonadotropine equine modifiee pour induire l'ovulation chez la jument et stimuler la production de testosterone chez l'etalon |
US6927034B2 (en) * | 1998-02-03 | 2005-08-09 | The Trustees Of Columbia University In The City Of New York | Methods for detecting trophoblast malignancy by HCG assay |
US7198954B1 (en) * | 1999-02-03 | 2007-04-03 | The Trustees Of Columbia University In The City Of New York | Methods for predicting pregnancy outcome in a subject by hCG assay |
US6500627B1 (en) * | 1998-02-03 | 2002-12-31 | The Trustees Of Columbia University In The City Of New York | Methods for predicting pregnancy outcome in a subject by HCG assay |
WO2001025277A1 (en) * | 1999-10-07 | 2001-04-12 | Maxygen Aps | Single-chain antagonist polypeptides |
US7081446B2 (en) | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
US20050130892A1 (en) * | 2003-03-07 | 2005-06-16 | Xencor, Inc. | BAFF variants and methods thereof |
US20060014248A1 (en) * | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
US7553930B2 (en) * | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
US20050221443A1 (en) * | 2003-01-06 | 2005-10-06 | Xencor, Inc. | Tumor necrosis factor super family agonists |
WO2013010840A2 (en) | 2011-07-18 | 2013-01-24 | Arts Biologics A/S | Long acting biologically active luteinizing hormone (lh) compound |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4840896A (en) * | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
EP0307402B1 (en) * | 1986-05-06 | 1993-08-11 | Genetics Institute, Inc. | Production of m-csf |
US4868119A (en) * | 1986-12-11 | 1989-09-19 | Genetics Institute, Inc. | Hematopoietic growth factors |
US4879227A (en) * | 1986-05-06 | 1989-11-07 | Genetics Institute, Inc. | Production of a recombinant human colony stimulating factor |
JPS63304997A (ja) * | 1987-06-08 | 1988-12-13 | Kyowa Hakko Kogyo Co Ltd | 魚類の生殖腺刺激ホルモン遺伝子 |
US5260421A (en) * | 1987-12-21 | 1993-11-09 | Applied Research Systems Ars Holding N.V. | Site-directed mutagenesis modified glycoprotein hormones |
ATE148171T1 (de) * | 1989-02-21 | 1997-02-15 | Univ Washington | Modifizierte formen von fortpflanzungshormonen |
-
1987
- 1987-12-21 US US07/136,236 patent/US5260421A/en not_active Expired - Lifetime
-
1988
- 1988-12-08 CA CA000585309A patent/CA1341284C/en not_active Expired - Lifetime
- 1988-12-21 AT AT88312143T patent/ATE95424T1/de not_active IP Right Cessation
- 1988-12-21 JP JP63323227A patent/JP2525048B2/ja not_active Expired - Lifetime
- 1988-12-21 EP EP88312143A patent/EP0322226B2/en not_active Expired - Lifetime
- 1988-12-21 ES ES88312143T patent/ES2059545T5/es not_active Expired - Lifetime
- 1988-12-21 DE DE3884776T patent/DE3884776T3/de not_active Expired - Lifetime
-
1993
- 1993-09-23 US US08/126,134 patent/US5352779A/en not_active Expired - Lifetime
-
1994
- 1994-07-28 US US08/281,123 patent/US5986068A/en not_active Expired - Lifetime
-
1995
- 1995-09-07 HK HK143395A patent/HK143395A/xx not_active IP Right Cessation
-
2000
- 2000-01-04 GR GR20000400007T patent/GR3032307T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2059545T5 (es) | 2000-05-01 |
EP0322226A3 (en) | 1990-06-13 |
HK143395A (en) | 1995-09-15 |
US5352779A (en) | 1994-10-04 |
US5260421A (en) | 1993-11-09 |
GR3032307T3 (en) | 2000-04-27 |
EP0322226A2 (en) | 1989-06-28 |
CA1341284C (en) | 2001-08-14 |
DE3884776T2 (de) | 1994-02-10 |
EP0322226B2 (en) | 1999-11-10 |
DE3884776D1 (de) | 1993-11-11 |
ATE95424T1 (de) | 1993-10-15 |
JP2525048B2 (ja) | 1996-08-14 |
DE3884776T3 (de) | 2000-06-21 |
EP0322226B1 (en) | 1993-10-06 |
US5986068A (en) | 1999-11-16 |
JPH022384A (ja) | 1990-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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