ATE115409T1 - Glykoprotein-hormonrezeptor-moleküle. - Google Patents

Glykoprotein-hormonrezeptor-moleküle.

Info

Publication number
ATE115409T1
ATE115409T1 AT90908349T AT90908349T ATE115409T1 AT E115409 T1 ATE115409 T1 AT E115409T1 AT 90908349 T AT90908349 T AT 90908349T AT 90908349 T AT90908349 T AT 90908349T AT E115409 T1 ATE115409 T1 AT E115409T1
Authority
AT
Austria
Prior art keywords
hormone receptor
receptor molecule
glycoprotein hormone
stimulating hormone
hormone
Prior art date
Application number
AT90908349T
Other languages
English (en)
Inventor
Karoly Nikolics
Keith C Mcfarland
Deborah L Segaloff
Peter H Seeburg
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE115409T1 publication Critical patent/ATE115409T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT90908349T 1989-05-05 1990-05-04 Glykoprotein-hormonrezeptor-moleküle. ATE115409T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34768389A 1989-05-05 1989-05-05

Publications (1)

Publication Number Publication Date
ATE115409T1 true ATE115409T1 (de) 1994-12-15

Family

ID=23364795

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94104166T ATE221123T1 (de) 1989-05-05 1990-05-04 Glykoprotein-hormonrezeptor-moleküle
AT90908349T ATE115409T1 (de) 1989-05-05 1990-05-04 Glykoprotein-hormonrezeptor-moleküle.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94104166T ATE221123T1 (de) 1989-05-05 1990-05-04 Glykoprotein-hormonrezeptor-moleküle

Country Status (9)

Country Link
EP (3) EP1199361A3 (de)
JP (1) JPH04505103A (de)
AT (2) ATE221123T1 (de)
AU (1) AU5732190A (de)
DE (2) DE69015175T2 (de)
DK (2) DK0614975T3 (de)
ES (2) ES2180550T3 (de)
HK (1) HK1046429A1 (de)
WO (1) WO1990013643A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体
DE69131393T2 (de) 1990-09-10 1999-11-04 Takeda Chemical Industries, Ltd. Menschlicher Rezeptor für luteinisierendes Hormon und Choriongonadotropin
DK0575357T3 (da) * 1991-03-15 2002-11-25 Applied Research Systems Human receptor for follikelstimulerende hormon
AU3949893A (en) * 1992-03-30 1993-11-08 Akzo Nobel N.V. Human gonadotropin receptor (FSH receptor)
US6033903A (en) * 1995-06-02 2000-03-07 Applied Research Systems, ARS Holding N.V. Method of expressing and secreting soluble extracellular domains of human gonadotropin hormone receptors
EP0910648A1 (de) * 1996-04-15 1999-04-28 The Board Of Trustees Of The Leland Stanford Junior University Zusammensetzungen, welche einen löslichen 7-transmembrandomänen g-protein gekoppelten rezeptor enthalten und verfahren
US5858716A (en) 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
EP1049779A2 (de) * 1998-01-20 2000-11-08 Wilex Biotechnology GmbH Lh-rezeptorgenpromoter für gewebenspezifischen genexpression
GB9909661D0 (en) 1998-06-06 1999-06-23 Rsr Ltd Assays for TSH receptor autoantibodies
ES2732276T3 (es) 2001-08-23 2019-11-21 Rsr Ltd Regiones del epítopo de un receptor de tirotropina (TSH), usos del mismo y anticuerpos para el mismo

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560649A (en) * 1981-10-15 1985-12-24 Cornell Research Foundation Assaying for hLH or hCG with immobilized hormone receptors
US4761371A (en) * 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
US4921808A (en) * 1986-06-25 1990-05-01 The Albany Medical College Of Union University Method for determining follicle stimulating hormone
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
DE68927461T2 (de) * 1989-12-14 1997-03-20 B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体
FR2657014A1 (fr) * 1990-01-15 1991-07-19 Inst Nat Sante Rech Med Recepteur humain de la tsh. sequence codant pour ce recepteur.

Also Published As

Publication number Publication date
DK0471030T3 (da) 1995-05-29
HK1046429A1 (en) 2003-01-10
DE69015175D1 (de) 1995-01-26
EP0614975A1 (de) 1994-09-14
WO1990013643A3 (en) 1991-01-10
ATE221123T1 (de) 2002-08-15
DK0614975T3 (da) 2002-11-11
AU5732190A (en) 1990-11-29
EP0471030A1 (de) 1992-02-19
ES2068388T3 (es) 1995-04-16
WO1990013643A2 (en) 1990-11-15
DE69033990D1 (de) 2002-08-29
JPH04505103A (ja) 1992-09-10
EP0471030B1 (de) 1994-12-14
DE69033990T2 (de) 2003-02-13
ES2180550T3 (es) 2003-02-16
EP0614975B1 (de) 2002-07-24
DE69015175T2 (de) 1995-06-29
EP1199361A3 (de) 2004-03-10
EP1199361A2 (de) 2002-04-24

Similar Documents

Publication Publication Date Title
ES2068791T1 (es) Metodos y acido desoxirribonucleico para la preparacion de proteina de factor de tejido.
EP0335901A4 (en) Methods and compositions for the treatment of non-ige-mediated diseases
ATE162532T1 (de) Merschliches cnp-gen und vorläufer protein
ATE221123T1 (de) Glykoprotein-hormonrezeptor-moleküle
DK0669979T3 (da) C-C CKR-1, kemokinreceptor
EP0786995A4 (de)
DK143492A (da) Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet
ATE95424T1 (de) Durch ''site-directed'' mutagenese modifzierte glukoprotein-hormone und verfahren zu deren verwendung.
ES548617A0 (es) Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo
ATE199167T1 (de) Nichtglykosyliertes fgf-4 und dieses enthaltende präparate
DK0470117T3 (da) Anvendelse af "calcitonin gene-related peptides" til fremstilling af lægemidler til behandling af erektile dysfunktioner
EE05497B1 (et) Polüpeptiid, lahustuv CRAM-1 polüpeptiid, polünukleotiid ja antikeha
IT8619055A0 (it) Composizioni farmaceutiche comprendenti peptidi del gruppo colecistochinina-cerulina per il trattamento terapeutico degli statidi shock e dell'insufficienza respiratoria e cardiocircolatoria.
EP0214254A1 (de) Melatoninhaltige mittel sowie deren verwendungen.
KR980002066A (ko) 변이형 인간 성장호르몬 및 그의 용도
DE69010294D1 (de) Verwendung von Antiprogestomimetika zur Stimulierung des Eisprungs.
DK1040191T3 (da) RANTES-mutanter og terapeutiske anvendelser heraf
EP0266993A3 (en) Method and therapeutic compositions for the treatment of bleeding disorders
EP0315118A3 (de) Endothelin kodierendes DNA und dessen Verwendung
ES2076141T3 (es) 5-aril-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
IT8620548A0 (it) Procedimento e dispositivo per la fabbricazione di prodotti in fibra di vetro, per esempio veli, feltri, filati e stoppini.
ATE139565T1 (de) Solubilisierung und reinigung des rezeptors für das gastrin-freisetzende peptid
ATE130194T1 (de) Subkutane verabreichung des humanen choriongonadotropins.
IT8619086A0 (it) Composizioni farmaceutiche comprendenti frammenti di acth per il trattamento terapeutico degli stati di shock e dell'insufficienza respiratoria e cardiocircolatoria.
王殿洪 et al. PURIFICATION AND CHARACTERIZATION OF INSULIN RECEPTORS FROM HUMAN PLACENTA

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time