AR246983A1 - Plasmido dna recombinante, linea celular y procedimiento para producir beta-ngf humano. - Google Patents

Plasmido dna recombinante, linea celular y procedimiento para producir beta-ngf humano.

Info

Publication number
AR246983A1
AR246983A1 AR90318408A AR31840890A AR246983A1 AR 246983 A1 AR246983 A1 AR 246983A1 AR 90318408 A AR90318408 A AR 90318408A AR 31840890 A AR31840890 A AR 31840890A AR 246983 A1 AR246983 A1 AR 246983A1
Authority
AR
Argentina
Prior art keywords
preparation
growth factor
eukaryotic cells
nerve growth
factor expression
Prior art date
Application number
AR90318408A
Other languages
English (en)
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Application granted granted Critical
Publication of AR246983A1 publication Critical patent/AR246983A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PLASMIDO DNA RECOMBINANTE, QUE TIENE LA ESTRUCTURA DEL PMSGPHNGF, MOSTRADA EN LAS FIGURAS 2 Y 3 O POR TENER LA ESTRUCTURA DEL PSV4OMTPHNGF, MOSTRADA EN LAS FIGURAS 4 Y 5 O POR TENER LA ESTRUCTURA DEL PSV4OPHNGF, MOSTRADA EN LAS FIGURAS 6 Y 7 Y LINEA CELULAR, QUE COMPRENDE LAS CELULAS MAMIFERAS TRANSFORMADAS CON LOS PLASMIDOS.
AR90318408A 1989-11-16 1990-11-19 Plasmido dna recombinante, linea celular y procedimiento para producir beta-ngf humano. AR246983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Publications (1)

Publication Number Publication Date
AR246983A1 true AR246983A1 (es) 1994-10-31

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90318408A AR246983A1 (es) 1989-11-16 1990-11-19 Plasmido dna recombinante, linea celular y procedimiento para producir beta-ngf humano.

Country Status (22)

Country Link
US (1) US5457034A (es)
EP (1) EP0432510B1 (es)
JP (2) JP3121611B2 (es)
KR (1) KR910009929A (es)
CN (1) CN1051934A (es)
AR (1) AR246983A1 (es)
AT (1) ATE214735T1 (es)
CA (1) CA2030108C (es)
DE (1) DE69033937T2 (es)
ES (1) ES2173856T3 (es)
FI (1) FI905691A (es)
HU (1) HUT61047A (es)
IE (1) IE904120A1 (es)
IL (1) IL96347A (es)
IT (1) IT1238348B (es)
NZ (1) NZ236058A (es)
PE (1) PE28191A1 (es)
PL (1) PL287811A1 (es)
PT (1) PT95911B (es)
TW (1) TW205069B (es)
YU (1) YU217890A (es)
ZA (1) ZA909122B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
US6964947B1 (en) 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
EP1123401A1 (en) * 1998-10-22 2001-08-16 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US6696238B2 (en) 2000-07-28 2004-02-24 Christopher J. Murphy Transplant media
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
EP2201960A1 (en) 2003-03-19 2010-06-30 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
US7910544B2 (en) 2003-07-17 2011-03-22 The General Hospital Corporation Conformationally constrained parthyroid hormone (PTH) analogs
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
JP2009545320A (ja) * 2006-08-04 2009-12-24 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン（ｐｔｈ）のポリペプチド誘導体
CN101260398B (zh) 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
BRPI0814962B8 (pt) * 2007-08-01 2021-05-25 Chugai Pharmaceutical Co Ltd métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
RU2604809C2 (ru) 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
EP4230732A1 (en) * 2021-07-30 2023-08-23 Chengdu Unovel Biopharma Co., Ltd. Recombinant cho cell, construction method therefor, and detection system and method using same
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
AU6655890A (en) 1991-05-23
CA2030108A1 (en) 1991-05-17
DE69033937D1 (de) 2002-04-25
IT8948564A0 (it) 1989-11-16
DE69033937T2 (de) 2002-11-14
CA2030108C (en) 1998-04-28
ATE214735T1 (de) 2002-04-15
EP0432510B1 (en) 2002-03-20
US5457034A (en) 1995-10-10
ZA909122B (en) 1991-09-25
IL96347A (en) 1997-11-20
IT1238348B (it) 1993-07-13
FI905691A0 (fi) 1990-11-16
PT95911B (pt) 1998-01-30
IL96347A0 (en) 1991-08-16
PT95911A (pt) 1991-09-13
IT8948564A1 (it) 1991-05-16
ES2173856T3 (es) 2002-11-01
AU645998B2 (en) 1994-02-03
JP2001000194A (ja) 2001-01-09
TW205069B (es) 1993-05-01
KR910009929A (ko) 1991-06-28
EP0432510A1 (en) 1991-06-19
YU217890A (sh) 1993-05-28
NZ236058A (en) 1993-04-28
IE904120A1 (en) 1991-05-22
FI905691A (fi) 1991-05-17
JP3121611B2 (ja) 2001-01-09
PE28191A1 (es) 1991-10-28
JPH03224490A (ja) 1991-10-03
CN1051934A (zh) 1991-06-05
HU907174D0 (en) 1991-05-28
HUT61047A (en) 1992-11-30
PL287811A1 (en) 1991-12-02

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