CN1051934A - 在真核细胞中表达神经生长因子的基因构建物的制备方法 - Google Patents
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT04856489A IT1238348B (it) | 1989-11-16 | 1989-11-16 | Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. |
| IT48564A/89 | 1989-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1051934A true CN1051934A (zh) | 1991-06-05 |
Family
ID=11267348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN90109292A Pending CN1051934A (zh) | 1989-11-16 | 1990-11-16 | 在真核细胞中表达神经生长因子的基因构建物的制备方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5457034A (https=) |
| EP (1) | EP0432510B1 (https=) |
| JP (2) | JP3121611B2 (https=) |
| KR (1) | KR910009929A (https=) |
| CN (1) | CN1051934A (https=) |
| AR (1) | AR246983A1 (https=) |
| AT (1) | ATE214735T1 (https=) |
| CA (1) | CA2030108C (https=) |
| DE (1) | DE69033937T2 (https=) |
| ES (1) | ES2173856T3 (https=) |
| FI (1) | FI905691A7 (https=) |
| HU (1) | HUT61047A (https=) |
| IE (1) | IE904120A1 (https=) |
| IL (1) | IL96347A (https=) |
| IT (1) | IT1238348B (https=) |
| NZ (1) | NZ236058A (https=) |
| PE (1) | PE28191A1 (https=) |
| PL (1) | PL287811A1 (https=) |
| PT (1) | PT95911B (https=) |
| TW (1) | TW205069B (https=) |
| YU (1) | YU217890A (https=) |
| ZA (1) | ZA909122B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008106896A1 (en) * | 2007-03-07 | 2008-09-12 | Staidson (Beijing) Pharmaceutical Co., Ltd | Transgenic rodents having ngf beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins |
| CN102816766A (zh) * | 2012-05-04 | 2012-12-12 | 沈阳医学院 | 蛇毒神经生长因子活性多肽的筛选方法 |
| CN101927012B (zh) * | 2009-06-26 | 2013-08-14 | 丽珠医药集团股份有限公司 | 神经生长因子的病毒灭活方法 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| US6090781A (en) * | 1996-11-06 | 2000-07-18 | Genentech, Inc. | Stabilizing formulation for NGF |
| US6964947B1 (en) * | 1995-11-07 | 2005-11-15 | Genentech, Inc. | Stabilizing formulation for NGF |
| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| ATE412670T1 (de) | 1999-09-29 | 2008-11-15 | Gen Hospital Corp | Parathyroid hormon (pth) polypeptidderivate |
| AU2001279073B2 (en) | 2000-07-28 | 2006-08-24 | Christopher J. Murphy | Transplant media |
| AU2002339843B2 (en) * | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| US7795220B2 (en) | 2003-03-19 | 2010-09-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
| JP4871128B2 (ja) | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| WO2008019062A2 (en) * | 2006-08-04 | 2008-02-14 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| CN104072606B (zh) * | 2007-08-01 | 2017-09-22 | 总医院有限公司 | 利用g蛋白偶联受体和相关组合物的筛选方法 |
| MX358161B (es) | 2010-05-13 | 2018-08-06 | The General Hospital Corp Star | Analogos de hormona paratiroidea y usos para los mismos. |
| WO2023004784A1 (zh) * | 2021-07-30 | 2023-02-02 | 成都优洛生物科技有限公司 | 一种重组cho细胞、其构建方法、利用其的检测系统和方法 |
| CN115894705A (zh) * | 2021-09-30 | 2023-04-04 | 三生国健药业（上海）股份有限公司 | 一种β-NGF融合蛋白、其制备方法及用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US4796580A (en) * | 1987-09-11 | 1989-01-10 | Allied-Signal Inc. | Idle control valve for use with a throttle assembly of an internal combustion engine |
| JPH01211490A (ja) * | 1988-02-19 | 1989-08-24 | Tosoh Corp | ヒト神経成長因子遺伝子セグメント |
| US5272063A (en) * | 1988-11-22 | 1993-12-21 | Syntex (U.S.A.) Inc. | Process of making human nerve growth factor |
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1989
- 1989-11-16 IT IT04856489A patent/IT1238348B/it active IP Right Grant
-
1990
- 1990-11-13 NZ NZ236058A patent/NZ236058A/xx unknown
- 1990-11-14 IL IL96347A patent/IL96347A/xx active IP Right Grant
- 1990-11-14 ZA ZA909122A patent/ZA909122B/xx unknown
- 1990-11-15 PE PE1990177640A patent/PE28191A1/es unknown
- 1990-11-15 PT PT95911A patent/PT95911B/pt active IP Right Grant
- 1990-11-15 CA CA002030108A patent/CA2030108C/en not_active Expired - Fee Related
- 1990-11-15 IE IE412090A patent/IE904120A1/en unknown
- 1990-11-15 YU YU217890A patent/YU217890A/sh unknown
- 1990-11-16 KR KR1019900018690A patent/KR910009929A/ko not_active Ceased
- 1990-11-16 JP JP02312577A patent/JP3121611B2/ja not_active Expired - Fee Related
- 1990-11-16 CN CN90109292A patent/CN1051934A/zh active Pending
- 1990-11-16 FI FI905691A patent/FI905691A7/fi not_active IP Right Cessation
- 1990-11-16 EP EP90121961A patent/EP0432510B1/en not_active Expired - Lifetime
- 1990-11-16 DE DE69033937T patent/DE69033937T2/de not_active Expired - Fee Related
- 1990-11-16 HU HU907174A patent/HUT61047A/hu unknown
- 1990-11-16 AT AT90121961T patent/ATE214735T1/de not_active IP Right Cessation
- 1990-11-16 ES ES90121961T patent/ES2173856T3/es not_active Expired - Lifetime
- 1990-11-16 PL PL28781190A patent/PL287811A1/xx unknown
- 1990-11-19 AR AR90318408A patent/AR246983A1/es active
- 1990-12-28 TW TW079110979A patent/TW205069B/zh active
-
1993
- 1993-11-24 US US08/156,792 patent/US5457034A/en not_active Expired - Lifetime
-
2000
- 2000-05-02 JP JP2000133485A patent/JP2001000194A/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008106896A1 (en) * | 2007-03-07 | 2008-09-12 | Staidson (Beijing) Pharmaceutical Co., Ltd | Transgenic rodents having ngf beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins |
| US8487157B2 (en) | 2007-03-07 | 2013-07-16 | Staidson (Beijing) Pharmaceutical Co., Ltd. | Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins |
| CN101927012B (zh) * | 2009-06-26 | 2013-08-14 | 丽珠医药集团股份有限公司 | 神经生长因子的病毒灭活方法 |
| CN102816766A (zh) * | 2012-05-04 | 2012-12-12 | 沈阳医学院 | 蛇毒神经生长因子活性多肽的筛选方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| PE28191A1 (es) | 1991-10-28 |
| HU907174D0 (en) | 1991-05-28 |
| HUT61047A (en) | 1992-11-30 |
| YU217890A (sh) | 1993-05-28 |
| IE904120A1 (en) | 1991-05-22 |
| CA2030108A1 (en) | 1991-05-17 |
| KR910009929A (ko) | 1991-06-28 |
| US5457034A (en) | 1995-10-10 |
| DE69033937D1 (de) | 2002-04-25 |
| PT95911B (pt) | 1998-01-30 |
| JP2001000194A (ja) | 2001-01-09 |
| CA2030108C (en) | 1998-04-28 |
| AU6655890A (en) | 1991-05-23 |
| DE69033937T2 (de) | 2002-11-14 |
| PL287811A1 (en) | 1991-12-02 |
| IT8948564A0 (it) | 1989-11-16 |
| ZA909122B (en) | 1991-09-25 |
| FI905691A0 (fi) | 1990-11-16 |
| AR246983A1 (es) | 1994-10-31 |
| FI905691L (fi) | 1991-05-17 |
| IT1238348B (it) | 1993-07-13 |
| FI905691A7 (fi) | 1991-05-17 |
| PT95911A (pt) | 1991-09-13 |
| JPH03224490A (ja) | 1991-10-03 |
| EP0432510A1 (en) | 1991-06-19 |
| IT8948564A1 (it) | 1991-05-16 |
| TW205069B (https=) | 1993-05-01 |
| IL96347A0 (en) | 1991-08-16 |
| ES2173856T3 (es) | 2002-11-01 |
| IL96347A (en) | 1997-11-20 |
| JP3121611B2 (ja) | 2001-01-09 |
| ATE214735T1 (de) | 2002-04-15 |
| AU645998B2 (en) | 1994-02-03 |
| NZ236058A (en) | 1993-04-28 |
| EP0432510B1 (en) | 2002-03-20 |
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