CN1051934A - 在真核细胞中表达神经生长因子的基因构建物的制备方法 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Biochemistry (AREA)
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- Neurosurgery (AREA)
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- General Chemical & Material Sciences (AREA)
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- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT04856489A IT1238348B (it) | 1989-11-16 | 1989-11-16 | Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. |
| IT48564A/89 | 1989-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1051934A true CN1051934A (zh) | 1991-06-05 |
Family
ID=11267348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN90109292A Pending CN1051934A (zh) | 1989-11-16 | 1990-11-16 | 在真核细胞中表达神经生长因子的基因构建物的制备方法 |
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|---|---|
| US (1) | US5457034A (https=) |
| EP (1) | EP0432510B1 (https=) |
| JP (2) | JP3121611B2 (https=) |
| KR (1) | KR910009929A (https=) |
| CN (1) | CN1051934A (https=) |
| AR (1) | AR246983A1 (https=) |
| AT (1) | ATE214735T1 (https=) |
| CA (1) | CA2030108C (https=) |
| DE (1) | DE69033937T2 (https=) |
| ES (1) | ES2173856T3 (https=) |
| FI (1) | FI905691L (https=) |
| HU (1) | HUT61047A (https=) |
| IE (1) | IE904120A1 (https=) |
| IL (1) | IL96347A (https=) |
| IT (1) | IT1238348B (https=) |
| NZ (1) | NZ236058A (https=) |
| PE (1) | PE28191A1 (https=) |
| PL (1) | PL287811A1 (https=) |
| PT (1) | PT95911B (https=) |
| TW (1) | TW205069B (https=) |
| YU (1) | YU217890A (https=) |
| ZA (1) | ZA909122B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008106896A1 (en) * | 2007-03-07 | 2008-09-12 | Staidson (Beijing) Pharmaceutical Co., Ltd | Transgenic rodents having ngf beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins |
| CN102816766A (zh) * | 2012-05-04 | 2012-12-12 | 沈阳医学院 | 蛇毒神经生长因子活性多肽的筛选方法 |
| CN101927012B (zh) * | 2009-06-26 | 2013-08-14 | 丽珠医药集团股份有限公司 | 神经生长因子的病毒灭活方法 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| US6090781A (en) * | 1996-11-06 | 2000-07-18 | Genentech, Inc. | Stabilizing formulation for NGF |
| US6964947B1 (en) | 1995-11-07 | 2005-11-15 | Genentech, Inc. | Stabilizing formulation for NGF |
| AU1447600A (en) * | 1998-10-22 | 2000-05-08 | Thomas J. Gardella | Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) |
| AU7734800A (en) * | 1999-09-29 | 2001-04-30 | General Hospital Corporation, The | Polypeptide derivatives of parathyroid hormone (pth) |
| DE60040678D1 (en) | 1999-09-29 | 2008-12-11 | Gen Hospital Corp | Parathyroid hormon (pth) polypeptidderivate |
| EP1305040B1 (en) * | 2000-07-28 | 2009-09-09 | Christopher J. Murphy | Transplant media |
| CA2454275C (en) * | 2001-07-23 | 2012-10-23 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| US7795220B2 (en) | 2003-03-19 | 2010-09-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
| WO2005009358A2 (en) | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| EP2054077A4 (en) * | 2006-08-04 | 2010-10-13 | Gen Hospital Corp | POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) |
| AU2008282805B2 (en) | 2007-08-01 | 2014-05-01 | Chugai Pharmaceutical Co., Ltd. | Screening methods using G-protein coupled receptors and related compositions |
| WO2011143406A2 (en) | 2010-05-13 | 2011-11-17 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| JP2024527197A (ja) * | 2021-07-30 | 2024-07-23 | チェンドゥ ユノヴェル バイオファーマ カンパニー リミテッド． | 組換えｃｈｏ細胞、その構築方法、並びにそれを用いた検出システム及び方法 |
| CN115894705A (zh) * | 2021-09-30 | 2023-04-04 | 三生国健药业（上海）股份有限公司 | 一种β-NGF融合蛋白、其制备方法及用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US4796580A (en) * | 1987-09-11 | 1989-01-10 | Allied-Signal Inc. | Idle control valve for use with a throttle assembly of an internal combustion engine |
| JPH01211490A (ja) * | 1988-02-19 | 1989-08-24 | Tosoh Corp | ヒト神経成長因子遺伝子セグメント |
| US5272063A (en) * | 1988-11-22 | 1993-12-21 | Syntex (U.S.A.) Inc. | Process of making human nerve growth factor |
-
1989
- 1989-11-16 IT IT04856489A patent/IT1238348B/it active IP Right Grant
-
1990
- 1990-11-13 NZ NZ236058A patent/NZ236058A/xx unknown
- 1990-11-14 IL IL96347A patent/IL96347A/xx active IP Right Grant
- 1990-11-14 ZA ZA909122A patent/ZA909122B/xx unknown
- 1990-11-15 PE PE1990177640A patent/PE28191A1/es unknown
- 1990-11-15 CA CA002030108A patent/CA2030108C/en not_active Expired - Fee Related
- 1990-11-15 IE IE412090A patent/IE904120A1/en unknown
- 1990-11-15 PT PT95911A patent/PT95911B/pt active IP Right Grant
- 1990-11-15 YU YU217890A patent/YU217890A/sh unknown
- 1990-11-16 AT AT90121961T patent/ATE214735T1/de not_active IP Right Cessation
- 1990-11-16 DE DE69033937T patent/DE69033937T2/de not_active Expired - Fee Related
- 1990-11-16 ES ES90121961T patent/ES2173856T3/es not_active Expired - Lifetime
- 1990-11-16 CN CN90109292A patent/CN1051934A/zh active Pending
- 1990-11-16 KR KR1019900018690A patent/KR910009929A/ko not_active Ceased
- 1990-11-16 PL PL28781190A patent/PL287811A1/xx unknown
- 1990-11-16 JP JP02312577A patent/JP3121611B2/ja not_active Expired - Fee Related
- 1990-11-16 EP EP90121961A patent/EP0432510B1/en not_active Expired - Lifetime
- 1990-11-16 HU HU907174A patent/HUT61047A/hu unknown
- 1990-11-16 FI FI905691A patent/FI905691L/fi not_active IP Right Cessation
- 1990-11-19 AR AR90318408A patent/AR246983A1/es active
- 1990-12-28 TW TW079110979A patent/TW205069B/zh active
-
1993
- 1993-11-24 US US08/156,792 patent/US5457034A/en not_active Expired - Lifetime
-
2000
- 2000-05-02 JP JP2000133485A patent/JP2001000194A/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008106896A1 (en) * | 2007-03-07 | 2008-09-12 | Staidson (Beijing) Pharmaceutical Co., Ltd | Transgenic rodents having ngf beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins |
| US8487157B2 (en) | 2007-03-07 | 2013-07-16 | Staidson (Beijing) Pharmaceutical Co., Ltd. | Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins |
| CN101927012B (zh) * | 2009-06-26 | 2013-08-14 | 丽珠医药集团股份有限公司 | 神经生长因子的病毒灭活方法 |
| CN102816766A (zh) * | 2012-05-04 | 2012-12-12 | 沈阳医学院 | 蛇毒神经生长因子活性多肽的筛选方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| YU217890A (sh) | 1993-05-28 |
| PT95911A (pt) | 1991-09-13 |
| JPH03224490A (ja) | 1991-10-03 |
| ES2173856T3 (es) | 2002-11-01 |
| IL96347A0 (en) | 1991-08-16 |
| FI905691A7 (fi) | 1991-05-17 |
| IL96347A (en) | 1997-11-20 |
| KR910009929A (ko) | 1991-06-28 |
| IT8948564A1 (it) | 1991-05-16 |
| CA2030108C (en) | 1998-04-28 |
| JP3121611B2 (ja) | 2001-01-09 |
| EP0432510B1 (en) | 2002-03-20 |
| TW205069B (https=) | 1993-05-01 |
| DE69033937D1 (de) | 2002-04-25 |
| ZA909122B (en) | 1991-09-25 |
| HU907174D0 (en) | 1991-05-28 |
| AU645998B2 (en) | 1994-02-03 |
| US5457034A (en) | 1995-10-10 |
| IT1238348B (it) | 1993-07-13 |
| EP0432510A1 (en) | 1991-06-19 |
| FI905691A0 (fi) | 1990-11-16 |
| IT8948564A0 (it) | 1989-11-16 |
| PL287811A1 (en) | 1991-12-02 |
| NZ236058A (en) | 1993-04-28 |
| ATE214735T1 (de) | 2002-04-15 |
| AR246983A1 (es) | 1994-10-31 |
| JP2001000194A (ja) | 2001-01-09 |
| HUT61047A (en) | 1992-11-30 |
| CA2030108A1 (en) | 1991-05-17 |
| FI905691L (fi) | 1991-05-17 |
| AU6655890A (en) | 1991-05-23 |
| PE28191A1 (es) | 1991-10-28 |
| DE69033937T2 (de) | 2002-11-14 |
| PT95911B (pt) | 1998-01-30 |
| IE904120A1 (en) | 1991-05-22 |
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