ES2173856T3 - Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas. - Google Patents

Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas.

Info

Publication number
ES2173856T3
ES2173856T3 ES90121961T ES90121961T ES2173856T3 ES 2173856 T3 ES2173856 T3 ES 2173856T3 ES 90121961 T ES90121961 T ES 90121961T ES 90121961 T ES90121961 T ES 90121961T ES 2173856 T3 ES2173856 T3 ES 2173856T3
Authority
ES
Spain
Prior art keywords
growth factor
cells
eucariot
expression
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90121961T
Other languages
English (en)
Spanish (es)
Inventor
Valle Francesco Della
Lanfranco Callegaro
Alessandro Negro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2173856T3 publication Critical patent/ES2173856T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES90121961T 1989-11-16 1990-11-16 Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas. Expired - Lifetime ES2173856T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Publications (1)

Publication Number Publication Date
ES2173856T3 true ES2173856T3 (es) 2002-11-01

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90121961T Expired - Lifetime ES2173856T3 (es) 1989-11-16 1990-11-16 Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas.

Country Status (22)

Country Link
US (1) US5457034A (https=)
EP (1) EP0432510B1 (https=)
JP (2) JP3121611B2 (https=)
KR (1) KR910009929A (https=)
CN (1) CN1051934A (https=)
AR (1) AR246983A1 (https=)
AT (1) ATE214735T1 (https=)
CA (1) CA2030108C (https=)
DE (1) DE69033937T2 (https=)
ES (1) ES2173856T3 (https=)
FI (1) FI905691A7 (https=)
HU (1) HUT61047A (https=)
IE (1) IE904120A1 (https=)
IL (1) IL96347A (https=)
IT (1) IT1238348B (https=)
NZ (1) NZ236058A (https=)
PE (1) PE28191A1 (https=)
PL (1) PL287811A1 (https=)
PT (1) PT95911B (https=)
TW (1) TW205069B (https=)
YU (1) YU217890A (https=)
ZA (1) ZA909122B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
US6964947B1 (en) * 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
AU2001279073B2 (en) 2000-07-28 2006-08-24 Christopher J. Murphy Transplant media
AU2002339843B2 (en) * 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
CN101260398B (zh) * 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
CN104072606B (zh) * 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
MX358161B (es) 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
WO2023004784A1 (zh) * 2021-07-30 2023-02-02 成都优洛生物科技有限公司 一种重组cho细胞、其构建方法、利用其的检测系统和方法
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
PE28191A1 (es) 1991-10-28
HU907174D0 (en) 1991-05-28
HUT61047A (en) 1992-11-30
YU217890A (sh) 1993-05-28
IE904120A1 (en) 1991-05-22
CA2030108A1 (en) 1991-05-17
KR910009929A (ko) 1991-06-28
US5457034A (en) 1995-10-10
DE69033937D1 (de) 2002-04-25
PT95911B (pt) 1998-01-30
JP2001000194A (ja) 2001-01-09
CA2030108C (en) 1998-04-28
AU6655890A (en) 1991-05-23
DE69033937T2 (de) 2002-11-14
PL287811A1 (en) 1991-12-02
IT8948564A0 (it) 1989-11-16
ZA909122B (en) 1991-09-25
FI905691A0 (fi) 1990-11-16
AR246983A1 (es) 1994-10-31
CN1051934A (zh) 1991-06-05
FI905691L (fi) 1991-05-17
IT1238348B (it) 1993-07-13
FI905691A7 (fi) 1991-05-17
PT95911A (pt) 1991-09-13
JPH03224490A (ja) 1991-10-03
EP0432510A1 (en) 1991-06-19
IT8948564A1 (it) 1991-05-16
TW205069B (https=) 1993-05-01
IL96347A0 (en) 1991-08-16
IL96347A (en) 1997-11-20
JP3121611B2 (ja) 2001-01-09
ATE214735T1 (de) 2002-04-15
AU645998B2 (en) 1994-02-03
NZ236058A (en) 1993-04-28
EP0432510B1 (en) 2002-03-20

Similar Documents

Publication Publication Date Title
ES2173856T3 (es) Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas.
ES2094159T3 (es) Produccion de factor de crecimiento de celulas endoteliales vasculares.
ES2037083T3 (es) Gen de eritropoietina: expresion de alto nivel en celulas de mamiferos transfectadas de forma estable.
ES2147553T3 (es) Vectores virales recombinantes para la expresion en unas celulas musculares.
ES8600783A1 (es) Procedimiento para la preparacion de la hormona polipeptidica factor de crecimiento de nervios de humano.
CA2223433A1 (en) Ob protein compositions and methods
HUP9801697A2 (hu) Új protein és eljárás előállítására
ES2181723T3 (es) Formulaciones farmaceuticas de factor de crecimiento nervioso.
CA2323073A1 (en) Uses for human non-autologous mesenchymal stem cells
AR052206A2 (es) Reforzador para un promotor de genes, metodo para activar o incrementar la expresion de un promotor de genes, secuencia de adn quimerico,plantas celulas y propagulos que comprenden dichos reforzadores
DK0702563T3 (da) Sammensætninger og fremgangsmåder til behandling af cancer og hyperproliferative sygdomme
DE68929134D1 (de) Endothelin-DNA und Verwendung davon
ATE141288T1 (de) Melaninkonzentrierende hormone und dns die diese expremieren
ATE87973T1 (de) Expressionsvektoren fuer die produktion von humanem gm-csf in saengerzellen.
DE69012377D1 (de) Polypeptid und dessen Herstellung.
ES2187646T3 (es) Procedimientos para el tratamiento de inflamaciones y composiciones correspondientes.
IT1228925B (it) Procedimento per la preparazione dell'ormone della crescita umano
DE69817180D1 (de) Zns neuroregenerative zusammensetzungen und deren verwendungen
DE3853743T2 (de) Rekombinanter menschlicher ADF.
EP0315118A3 (en) Dna coding for endothelin and use thereof
DE3689921D1 (de) Menschlicher plazentarer angiogenischer Faktor, geeignet für die Reizung der Kapillarsynthese, der Endothelzellprotease, der DNS-Synthese und der Absiedlung.
WO1990002183A1 (en) Production of a novel lymphokine exhibiting differentiation inhibitory activity
ATE131175T1 (de) Protein mit fibroblasten-wachstumsfaktor- rezeptoraktivität.
ES2061524T3 (es) Un vector plasmidico para la expresion en bacillus y empleado para la clonacion del gen estructural que codifica la hormona de crecimiento humana y un metodo para la produccion de la hormona.
KR102190790B1 (ko) 변형된 egf 단백질의 생산 방법

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 432510

Country of ref document: ES