IT1228925B - Procedimento per la preparazione dell'ormone della crescita umano - Google Patents

Procedimento per la preparazione dell'ormone della crescita umano

Info

Publication number
IT1228925B
IT1228925B IT8721616A IT2161687A IT1228925B IT 1228925 B IT1228925 B IT 1228925B IT 8721616 A IT8721616 A IT 8721616A IT 2161687 A IT2161687 A IT 2161687A IT 1228925 B IT1228925 B IT 1228925B
Authority
IT
Italy
Prior art keywords
preparation
growth hormone
human growth
procedure
hgh
Prior art date
Application number
IT8721616A
Other languages
English (en)
Other versions
IT8721616A0 (it
Inventor
Guido Grandi
Elisabetta Franchi
Federico Maisano
Silvia Astrua Testori
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Priority to IT8721616A priority Critical patent/IT1228925B/it
Publication of IT8721616A0 publication Critical patent/IT8721616A0/it
Priority to EP88111842A priority patent/EP0306673B1/en
Priority to AT88111842T priority patent/ATE87654T1/de
Priority to DE8888111842T priority patent/DE3879823T2/de
Priority to ES88111842T priority patent/ES2053635T3/es
Priority to JP63194701A priority patent/JPH074254B2/ja
Application granted granted Critical
Publication of IT1228925B publication Critical patent/IT1228925B/it
Priority to US07/834,486 priority patent/US5268277A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
IT8721616A 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano IT1228925B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT8721616A IT1228925B (it) 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano
EP88111842A EP0306673B1 (en) 1987-08-07 1988-07-22 A method for the preparation of human growth hormone
AT88111842T ATE87654T1 (de) 1987-08-07 1988-07-22 Verfahren zur herstellung von menschlichem wachstumshormon.
DE8888111842T DE3879823T2 (de) 1987-08-07 1988-07-22 Verfahren zur herstellung von menschlichem wachstumshormon.
ES88111842T ES2053635T3 (es) 1987-08-07 1988-07-22 Metodo para la preparacion de la hormona humana del crecimiento.
JP63194701A JPH074254B2 (ja) 1987-08-07 1988-08-05 ヒト成長ホルモンの製法
US07/834,486 US5268277A (en) 1987-08-07 1992-02-12 Method for the preparation of human growth hormone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8721616A IT1228925B (it) 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano

Publications (2)

Publication Number Publication Date
IT8721616A0 IT8721616A0 (it) 1987-08-07
IT1228925B true IT1228925B (it) 1991-07-10

Family

ID=11184375

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8721616A IT1228925B (it) 1987-08-07 1987-08-07 Procedimento per la preparazione dell'ormone della crescita umano

Country Status (6)

Country Link
EP (1) EP0306673B1 (it)
JP (1) JPH074254B2 (it)
AT (1) ATE87654T1 (it)
DE (1) DE3879823T2 (it)
ES (1) ES2053635T3 (it)
IT (1) IT1228925B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1223577B (it) * 1987-12-22 1990-09-19 Eniricerche Spa Procedimento migliorato per la preparazione dell'ormone della crescita umano naturale in forma pura
IT1231156B (it) * 1989-07-19 1991-11-19 Eniricerche Spa Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
JP3869874B2 (ja) * 1995-11-15 2007-01-17 大日本住友製薬株式会社 急性肝不全治療剤
WO1997018833A1 (en) * 1995-11-22 1997-05-29 Amgen Inc. Methods of increasing lean tissue mass using ob protein compositions
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
KR100530598B1 (ko) * 1997-06-10 2005-11-23 다카라 바이오 가부시키가이샤 초내열성 프로테아제 발현계
AU731758B2 (en) * 1998-07-08 2001-04-05 Mitsui Chemicals, Inc. Method for secretory production of human growth hormone
JP5160878B2 (ja) * 2007-12-21 2013-03-13 浜松ホトニクス株式会社 試料同定装置および試料同定方法
US9902753B2 (en) * 2012-06-05 2018-02-27 Cj Healthcare Corporation Method of purifying a long-acting human growth hormone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
JP2500312B2 (ja) * 1986-01-13 1996-05-29 工業技術院長 ヒト成長ホルモンの生産法
EP0245218B1 (en) * 1986-05-07 1993-12-29 ENIRICERCHE S.p.A. A plasmid vector for expression in bacillus and used for cloning the structural gene which codes for the human growth hormone and a method of producing the hormone

Also Published As

Publication number Publication date
ATE87654T1 (de) 1993-04-15
EP0306673A1 (en) 1989-03-15
EP0306673B1 (en) 1993-03-31
ES2053635T3 (es) 1994-08-01
JPH074254B2 (ja) 1995-01-25
IT8721616A0 (it) 1987-08-07
DE3879823T2 (de) 1993-07-08
DE3879823D1 (de) 1993-05-06
JPH02446A (ja) 1990-01-05

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970829