IT1231156B - Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento. - Google Patents

Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.

Info

Publication number
IT1231156B
IT1231156B IT8921228A IT2122889A IT1231156B IT 1231156 B IT1231156 B IT 1231156B IT 8921228 A IT8921228 A IT 8921228A IT 2122889 A IT2122889 A IT 2122889A IT 1231156 B IT1231156 B IT 1231156B
Authority
IT
Italy
Prior art keywords
human beta
secretion
expression
interleuchina
obtaining
Prior art date
Application number
IT8921228A
Other languages
English (en)
Other versions
IT8921228A0 (it
Inventor
Ada Velati Bellini
Giuliano Galli
Giuseppe Lucchese
Guido Grandi
Original Assignee
Eniricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa filed Critical Eniricerche Spa
Publication of IT8921228A0 publication Critical patent/IT8921228A0/it
Priority to IT8921228A priority Critical patent/IT1231156B/it
Priority to ES90113414T priority patent/ES2058695T3/es
Priority to EP90113414A priority patent/EP0409098B1/en
Priority to AT90113414T priority patent/ATE107701T1/de
Priority to DK90113414.8T priority patent/DK0409098T3/da
Priority to DE69010096T priority patent/DE69010096T2/de
Priority to CA002021406A priority patent/CA2021406A1/en
Application granted granted Critical
Publication of IT1231156B publication Critical patent/IT1231156B/it
Priority to US08/072,692 priority patent/US5437988A/en
Priority to US08/405,775 priority patent/US5728571A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IT8921228A 1989-07-19 1989-07-19 Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento. IT1231156B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8921228A IT1231156B (it) 1989-07-19 1989-07-19 Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.
DK90113414.8T DK0409098T3 (da) 1989-07-19 1990-07-13 Ekspression og secernering af moden human beta-interleukin-1 i Bacillus subtilis samt midler og fremgangsmåder til opnåelse heraf
EP90113414A EP0409098B1 (en) 1989-07-19 1990-07-13 The expression and secretion of mature human beta interleukin-1 in bacillus subtilis and means and methods for its achievement
AT90113414T ATE107701T1 (de) 1989-07-19 1990-07-13 Expression und sekretion von reifem menschlichem beta-interleukin-1 in bacillus subtilis und mittel und verfahren zu deren ausführung.
ES90113414T ES2058695T3 (es) 1989-07-19 1990-07-13 La expresion y secrecion de interleucina-1 beta humana, sin secuencias de aminoacidos extrañas a la molecula natural, por celulas de bacillus subtilis y medios y metodos para conseguirlo.
DE69010096T DE69010096T2 (de) 1989-07-19 1990-07-13 Expression und Sekretion von reifem menschlichem beta-Interleukin-1 in Bacillus subtilis und Mittel und Verfahren zu deren Ausführung.
CA002021406A CA2021406A1 (en) 1989-07-19 1990-07-18 Expression and secretion of mature human beta interleukin-1 in bacillus subtilis and means and methods for its achievement
US08/072,692 US5437988A (en) 1989-07-19 1993-06-07 Expression and secretion of mature human beta interleukin-1 in Bacillus subtilis and means and methods for its achievement
US08/405,775 US5728571A (en) 1989-07-19 1995-03-17 Expression and secretion of mature human beta interleukin-1 in Bacillus subtilis and means and methods for its achievement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921228A IT1231156B (it) 1989-07-19 1989-07-19 Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.

Publications (2)

Publication Number Publication Date
IT8921228A0 IT8921228A0 (it) 1989-07-19
IT1231156B true IT1231156B (it) 1991-11-19

Family

ID=11178709

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921228A IT1231156B (it) 1989-07-19 1989-07-19 Espressione e secrezione di interleuchina 1 beta umana matura in bacillus subtilis e mezzi e metodi per il suo ottenimento.

Country Status (8)

Country Link
US (2) US5437988A (it)
EP (1) EP0409098B1 (it)
AT (1) ATE107701T1 (it)
CA (1) CA2021406A1 (it)
DE (1) DE69010096T2 (it)
DK (1) DK0409098T3 (it)
ES (1) ES2058695T3 (it)
IT (1) IT1231156B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis
US6270758B1 (en) 1998-10-08 2001-08-07 Duke University Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
CA2452417C (en) 2001-07-13 2013-08-20 Pepharm R & D Limited Compositions comprising the biologicially active peptide ysl
EP1627885B8 (en) 2003-04-30 2015-02-18 Innovative Medicine and Any Peptide Pharmaceuticals Corp Polypeptide capable of assisting digestive organ absorption
TWI353252B (en) 2004-04-28 2011-12-01 Cms Peptides Patent Holding Company Ltd Biologically active peptide vapeehptllteaplnpk der
US20070061899A1 (en) * 2005-04-13 2007-03-15 The Trustees Of Columbia University In The City Of New York Transgenic mammal with constitutive, tissue-specific cytokine expression and use as a cancer model
CN101501062B (zh) 2005-07-26 2012-07-18 康哲医药研究(深圳)有限公司 新型生物活性肽及其新用途
WO2011038290A2 (en) 2009-09-25 2011-03-31 The U. S. A., As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to hiv-1 and their use
US9695230B2 (en) 2011-12-08 2017-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Broadly neutralizing HIV-1 VRC07 antibodies that bind to the CD4-binding site of the envelope protein
US9534041B2 (en) 2013-02-12 2017-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that neutralize a norovirus
US10000556B2 (en) 2013-05-09 2018-06-19 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Single-domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use
US10072070B2 (en) 2014-12-05 2018-09-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Potent anti-influenza A neuraminidase subtype N1 antibody
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE251158C (it) *
GB2171703B (en) * 1985-01-18 1989-11-15 Agency Ind Science Techn Expression-secretion vector for gene expression and protein secretion, recombinant dna including the vector, and method of producing proteins by use of the re
IT1186750B (it) * 1985-07-10 1987-12-16 Eniricerche Spa Vettore di clonaggio,molecole di dna ricombinante,ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni
JPH0669377B2 (ja) * 1985-11-25 1994-09-07 工業技術院長 Ｄｎａ塩基配列およびベクタ−
IT1196484B (it) * 1986-07-11 1988-11-16 Sclavo Spa Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe
DD251158A1 (de) * 1986-07-17 1987-11-04 Adw Ddr Verfahren zur herstellung von streptokokken-vektorplasmiden mit polylinker
IT1228925B (it) * 1987-08-07 1991-07-10 Eniricerche Spa Procedimento per la preparazione dell'ormone della crescita umano
IT1226713B (it) * 1988-08-05 1991-02-05 Eniricerche Spa Procedimento per la preparazione di interleuchina 1 beta umana ricombinante in forma omogenea.

Also Published As

Publication number Publication date
EP0409098A1 (en) 1991-01-23
DE69010096D1 (de) 1994-07-28
ES2058695T3 (es) 1994-11-01
IT8921228A0 (it) 1989-07-19
DK0409098T3 (da) 1994-07-25
ATE107701T1 (de) 1994-07-15
EP0409098B1 (en) 1994-06-22
DE69010096T2 (de) 1994-10-13
US5437988A (en) 1995-08-01
CA2021406A1 (en) 1991-01-20
US5728571A (en) 1998-03-17

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970710