KR910009929A - 진핵세포에서 신경성장인자의 발현을 위한 유전자 구조의 제조방법 - Google Patents

진핵세포에서 신경성장인자의 발현을 위한 유전자 구조의 제조방법 Download PDF

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Publication number
KR910009929A
KR910009929A KR1019900018690A KR900018690A KR910009929A KR 910009929 A KR910009929 A KR 910009929A KR 1019900018690 A KR1019900018690 A KR 1019900018690A KR 900018690 A KR900018690 A KR 900018690A KR 910009929 A KR910009929 A KR 910009929A
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KR
South Korea
Prior art keywords
ngf
human
fragment
make
promoter
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Ceased
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KR1019900018690A
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English (en)
Korean (ko)
Inventor
델라발레 프란세스코
칼레가로 란프란코
네그로 알레산드로
Original Assignee
프란세스코 델라 발레
피디아 에스.피.에이.
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Application filed by 프란세스코 델라 발레, 피디아 에스.피.에이. filed Critical 프란세스코 델라 발레
Publication of KR910009929A publication Critical patent/KR910009929A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019900018690A 1989-11-16 1990-11-16 진핵세포에서 신경성장인자의 발현을 위한 유전자 구조의 제조방법 Ceased KR910009929A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.
IT48564A/89 1989-12-16

Publications (1)

Publication Number Publication Date
KR910009929A true KR910009929A (ko) 1991-06-28

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900018690A Ceased KR910009929A (ko) 1989-11-16 1990-11-16 진핵세포에서 신경성장인자의 발현을 위한 유전자 구조의 제조방법

Country Status (22)

Country Link
US (1) US5457034A (https=)
EP (1) EP0432510B1 (https=)
JP (2) JP3121611B2 (https=)
KR (1) KR910009929A (https=)
CN (1) CN1051934A (https=)
AR (1) AR246983A1 (https=)
AT (1) ATE214735T1 (https=)
CA (1) CA2030108C (https=)
DE (1) DE69033937T2 (https=)
ES (1) ES2173856T3 (https=)
FI (1) FI905691A7 (https=)
HU (1) HUT61047A (https=)
IE (1) IE904120A1 (https=)
IL (1) IL96347A (https=)
IT (1) IT1238348B (https=)
NZ (1) NZ236058A (https=)
PE (1) PE28191A1 (https=)
PL (1) PL287811A1 (https=)
PT (1) PT95911B (https=)
TW (1) TW205069B (https=)
YU (1) YU217890A (https=)
ZA (1) ZA909122B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
US6964947B1 (en) * 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
AU2001279073B2 (en) 2000-07-28 2006-08-24 Christopher J. Murphy Transplant media
AU2002339843B2 (en) * 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
CN101260398B (zh) * 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
CN104072606B (zh) * 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
MX358161B (es) 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
WO2023004784A1 (zh) * 2021-07-30 2023-02-02 成都优洛生物科技有限公司 一种重组cho细胞、其构建方法、利用其的检测系统和方法
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
PE28191A1 (es) 1991-10-28
HU907174D0 (en) 1991-05-28
HUT61047A (en) 1992-11-30
YU217890A (sh) 1993-05-28
IE904120A1 (en) 1991-05-22
CA2030108A1 (en) 1991-05-17
US5457034A (en) 1995-10-10
DE69033937D1 (de) 2002-04-25
PT95911B (pt) 1998-01-30
JP2001000194A (ja) 2001-01-09
CA2030108C (en) 1998-04-28
AU6655890A (en) 1991-05-23
DE69033937T2 (de) 2002-11-14
PL287811A1 (en) 1991-12-02
IT8948564A0 (it) 1989-11-16
ZA909122B (en) 1991-09-25
FI905691A0 (fi) 1990-11-16
AR246983A1 (es) 1994-10-31
CN1051934A (zh) 1991-06-05
FI905691L (fi) 1991-05-17
IT1238348B (it) 1993-07-13
FI905691A7 (fi) 1991-05-17
PT95911A (pt) 1991-09-13
JPH03224490A (ja) 1991-10-03
EP0432510A1 (en) 1991-06-19
IT8948564A1 (it) 1991-05-16
TW205069B (https=) 1993-05-01
IL96347A0 (en) 1991-08-16
ES2173856T3 (es) 2002-11-01
IL96347A (en) 1997-11-20
JP3121611B2 (ja) 2001-01-09
ATE214735T1 (de) 2002-04-15
AU645998B2 (en) 1994-02-03
NZ236058A (en) 1993-04-28
EP0432510B1 (en) 2002-03-20

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