PT94040A - Processo para preparacao de sais cristalinos, estaveis, muito soluveis em agua de mono-hidrato de 2',3'-didesoxi-2',3'-didesidro-timidina, de mono-hidrato de 2',3'-didesoxi-2'-fluoro -inosina com actividade antiviral e de composicoes farmaceuticas que os contem - Google Patents

Processo para preparacao de sais cristalinos, estaveis, muito soluveis em agua de mono-hidrato de 2',3'-didesoxi-2',3'-didesidro-timidina, de mono-hidrato de 2',3'-didesoxi-2'-fluoro -inosina com actividade antiviral e de composicoes farmaceuticas que os contem

Info

Publication number
PT94040A
PT94040A PT94040A PT9404090A PT94040A PT 94040 A PT94040 A PT 94040A PT 94040 A PT94040 A PT 94040A PT 9404090 A PT9404090 A PT 9404090A PT 94040 A PT94040 A PT 94040A
Authority
PT
Portugal
Prior art keywords
didesoxy
didesidro
soluable
inosine
thymidine
Prior art date
Application number
PT94040A
Other languages
English (en)
Other versions
PT94040B (pt
Inventor
Joseph Ballard Bogardus
Murray Arthur Kaplan
Robert Kevin Perrone
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT94040A publication Critical patent/PT94040A/pt
Publication of PT94040B publication Critical patent/PT94040B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
PT94040A 1989-05-15 1990-05-15 Processo para preparacao de sais cristalinos, estaveis, muito soluveis em agua de mono-hidrato de 2',3'-didesoxi-2',3'-didesidro-timidina, de mono-hidrato de 2',3'-didesoxi-2'-fluoro -inosina com actividade antiviral e de composicoes farmaceuticas que os contem PT94040B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01

Publications (2)

Publication Number Publication Date
PT94040A true PT94040A (pt) 1991-01-08
PT94040B PT94040B (pt) 1996-12-31

Family

ID=26997373

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94040A PT94040B (pt) 1989-05-15 1990-05-15 Processo para preparacao de sais cristalinos, estaveis, muito soluveis em agua de mono-hidrato de 2',3'-didesoxi-2',3'-didesidro-timidina, de mono-hidrato de 2',3'-didesoxi-2'-fluoro -inosina com actividade antiviral e de composicoes farmaceuticas que os contem

Country Status (16)

Country Link
EP (1) EP0398230B1 (pt)
KR (1) KR970001160B1 (pt)
CN (2) CN1027896C (pt)
AT (1) ATE162528T1 (pt)
AU (1) AU617614B2 (pt)
BG (1) BG60517B1 (pt)
DE (1) DE69031962T2 (pt)
DK (1) DK0398230T3 (pt)
EG (1) EG19154A (pt)
ES (1) ES2113851T3 (pt)
FI (1) FI95269C (pt)
GR (1) GR3025984T3 (pt)
HU (1) HU206628B (pt)
IE (1) IE81107B1 (pt)
NO (2) NO174102C (pt)
PT (1) PT94040B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
AU684604B2 (en) * 1994-01-07 1997-12-18 Aventis Inc. Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine
EP1765379A4 (en) * 2004-06-17 2009-05-27 Transform Pharmaceuticals Inc CO-CRISTAL PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
WO2009125841A1 (ja) 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
ZA891076B (en) * 1988-02-16 1990-10-31 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoronucleosides
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
EP0398230A2 (en) 1990-11-22
EG19154A (en) 1994-09-29
HUT53528A (en) 1990-11-28
NO933367L (no) 1990-11-16
NO902148L (no) 1990-11-16
PT94040B (pt) 1996-12-31
NO933367D0 (no) 1993-09-22
NO176609B (no) 1995-01-23
CN1109755A (zh) 1995-10-11
IE901734L (en) 1990-11-15
AU5501190A (en) 1990-11-15
FI902360A0 (fi) 1990-05-11
KR970001160B1 (ko) 1997-01-29
NO176609C (no) 1995-05-03
FI95269C (fi) 1996-01-10
HU903038D0 (en) 1990-09-28
ATE162528T1 (de) 1998-02-15
EP0398230A3 (en) 1991-06-26
EP0398230B1 (en) 1998-01-21
NO174102B (no) 1993-12-06
DE69031962D1 (de) 1998-02-26
CN1057443C (zh) 2000-10-18
FI95269B (fi) 1995-09-29
DE69031962T2 (de) 1998-09-17
BG92000A (bg) 1993-12-24
KR900017591A (ko) 1990-12-19
CN1047676A (zh) 1990-12-12
IE81107B1 (en) 2000-03-08
CN1027896C (zh) 1995-03-15
DK0398230T3 (da) 1998-09-21
HU206628B (en) 1992-12-28
NO174102C (no) 1994-03-16
NO902148D0 (no) 1990-05-15
ES2113851T3 (es) 1998-05-16
BG60517B1 (bg) 1995-07-28
GR3025984T3 (en) 1998-04-30
AU617614B2 (en) 1991-11-28

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19960911

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20090311