ES2113851T3 - Sales cristalinas estables y muy hidrosolubles antivirales de 2',3'-didesoxiinoxina monohidrato, 2',3'-didesoxi-2',3'-didehidrotimidina monohidrato y 2',3'-didesoxi-2'-fluoroinosina hemihidrato. - Google Patents

Sales cristalinas estables y muy hidrosolubles antivirales de 2',3'-didesoxiinoxina monohidrato, 2',3'-didesoxi-2',3'-didehidrotimidina monohidrato y 2',3'-didesoxi-2'-fluoroinosina hemihidrato.

Info

Publication number
ES2113851T3
ES2113851T3 ES90109065T ES90109065T ES2113851T3 ES 2113851 T3 ES2113851 T3 ES 2113851T3 ES 90109065 T ES90109065 T ES 90109065T ES 90109065 T ES90109065 T ES 90109065T ES 2113851 T3 ES2113851 T3 ES 2113851T3
Authority
ES
Spain
Prior art keywords
didesoxi
monohydrate
didesoxiinoxine
didehidrotimidine
hydrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90109065T
Other languages
English (en)
Inventor
Murray Arthur Kaplan
Robert Kevin Perrone
Joseph Ballard Bogardus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2113851T3 publication Critical patent/ES2113851T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • AIDS & HIV (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SALES CRISTALINAS MUY SOLUBLES EN AGUA, ESTABLES, DE 2,3-DIDEOXI-2,3 -DIDEHIDROTIMIDINA DE LA FORMULA FIG 2,3 - DIDEOXIINOSINA DE LA FORMULA FIG Y 2,3 -DIDEOXI-2-FLUOROINOSINA DE LA FORMULA FIG EN DONDE X ES UN CATION ORGANICO O INORGANICO. TALES SALES SON UTILES COMO AGENTES ANTIVIRICOS.
ES90109065T 1989-05-15 1990-05-14 Sales cristalinas estables y muy hidrosolubles antivirales de 2',3'-didesoxiinoxina monohidrato, 2',3'-didesoxi-2',3'-didehidrotimidina monohidrato y 2',3'-didesoxi-2'-fluoroinosina hemihidrato. Expired - Lifetime ES2113851T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01

Publications (1)

Publication Number Publication Date
ES2113851T3 true ES2113851T3 (es) 1998-05-16

Family

ID=26997373

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90109065T Expired - Lifetime ES2113851T3 (es) 1989-05-15 1990-05-14 Sales cristalinas estables y muy hidrosolubles antivirales de 2',3'-didesoxiinoxina monohidrato, 2',3'-didesoxi-2',3'-didehidrotimidina monohidrato y 2',3'-didesoxi-2'-fluoroinosina hemihidrato.

Country Status (16)

Country Link
EP (1) EP0398230B1 (es)
KR (1) KR970001160B1 (es)
CN (2) CN1027896C (es)
AT (1) ATE162528T1 (es)
AU (1) AU617614B2 (es)
BG (1) BG60517B1 (es)
DE (1) DE69031962T2 (es)
DK (1) DK0398230T3 (es)
EG (1) EG19154A (es)
ES (1) ES2113851T3 (es)
FI (1) FI95269C (es)
GR (1) GR3025984T3 (es)
HU (1) HU206628B (es)
IE (1) IE81107B1 (es)
NO (2) NO174102C (es)
PT (1) PT94040B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
JPH09511227A (ja) * 1994-01-07 1997-11-11 メレルファーマスーティカルズ インコーポレイテッド （ｅ）−２’−デオキシ−２’−（フルオロメチレン）シチジンの一水和物
US7803786B2 (en) * 2004-06-17 2010-09-28 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions and related methods of use
WO2009125841A1 (ja) 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
EP0329348B1 (en) * 1988-02-16 1995-07-12 Eli Lilly And Company 2',3'-Dideoxy-2',2'-difluoronucleosides
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
DK0398230T3 (da) 1998-09-21
HU206628B (en) 1992-12-28
GR3025984T3 (en) 1998-04-30
EP0398230B1 (en) 1998-01-21
FI95269C (fi) 1996-01-10
IE901734L (en) 1990-11-15
EP0398230A2 (en) 1990-11-22
NO933367D0 (no) 1993-09-22
NO176609B (no) 1995-01-23
NO174102C (no) 1994-03-16
FI902360A0 (fi) 1990-05-11
BG92000A (bg) 1993-12-24
IE81107B1 (en) 2000-03-08
DE69031962T2 (de) 1998-09-17
CN1047676A (zh) 1990-12-12
CN1057443C (zh) 2000-10-18
FI95269B (fi) 1995-09-29
CN1109755A (zh) 1995-10-11
PT94040A (pt) 1991-01-08
NO902148D0 (no) 1990-05-15
HUT53528A (en) 1990-11-28
CN1027896C (zh) 1995-03-15
ATE162528T1 (de) 1998-02-15
AU5501190A (en) 1990-11-15
BG60517B1 (bg) 1995-07-28
PT94040B (pt) 1996-12-31
NO176609C (no) 1995-05-03
NO902148L (no) 1990-11-16
EP0398230A3 (en) 1991-06-26
NO174102B (no) 1993-12-06
DE69031962D1 (de) 1998-02-26
KR900017591A (ko) 1990-12-19
HU903038D0 (en) 1990-09-28
AU617614B2 (en) 1991-11-28
KR970001160B1 (ko) 1997-01-29
NO933367L (no) 1990-11-16
EG19154A (en) 1994-09-29

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