DE69031962D1 - Antivirale, gut wasserlösliche, stabile, kristalline Salze von 2',3'-Dideoxyinosinmonohydrat, 2',3'-Dideoxy-2',3'-didehydrothymidinmonohydrat und 2',3'-Dideoxy-2'-fluoroinosinhemihydrat - Google Patents
Antivirale, gut wasserlösliche, stabile, kristalline Salze von 2',3'-Dideoxyinosinmonohydrat, 2',3'-Dideoxy-2',3'-didehydrothymidinmonohydrat und 2',3'-Dideoxy-2'-fluoroinosinhemihydratInfo
- Publication number
- DE69031962D1 DE69031962D1 DE69031962T DE69031962T DE69031962D1 DE 69031962 D1 DE69031962 D1 DE 69031962D1 DE 69031962 T DE69031962 T DE 69031962T DE 69031962 T DE69031962 T DE 69031962T DE 69031962 D1 DE69031962 D1 DE 69031962D1
- Authority
- DE
- Germany
- Prior art keywords
- dideoxy
- monohydrate
- fluoroinosine
- didehydrothymidine
- dideoxyinosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35206589A | 1989-05-15 | 1989-05-15 | |
US51426190A | 1990-05-01 | 1990-05-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69031962D1 true DE69031962D1 (de) | 1998-02-26 |
DE69031962T2 DE69031962T2 (de) | 1998-09-17 |
Family
ID=26997373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69031962T Expired - Fee Related DE69031962T2 (de) | 1989-05-15 | 1990-05-14 | Antivirale, gut wasserlösliche, stabile, kristalline Salze von 2',3'-Dideoxyinosinmonohydrat, 2',3'-Dideoxy-2',3'-didehydrothymidinmonohydrat und 2',3'-Dideoxy-2'-fluoroinosinhemihydrat |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0398230B1 (de) |
KR (1) | KR970001160B1 (de) |
CN (2) | CN1027896C (de) |
AT (1) | ATE162528T1 (de) |
AU (1) | AU617614B2 (de) |
BG (1) | BG60517B1 (de) |
DE (1) | DE69031962T2 (de) |
DK (1) | DK0398230T3 (de) |
EG (1) | EG19154A (de) |
ES (1) | ES2113851T3 (de) |
FI (1) | FI95269C (de) |
GR (1) | GR3025984T3 (de) |
HU (1) | HU206628B (de) |
IE (1) | IE81107B1 (de) |
NO (2) | NO174102C (de) |
PT (1) | PT94040B (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO920714L (no) * | 1991-03-01 | 1992-09-02 | Bristol Myers Squibb Co | Tetrahydrofuran-mellomprodukt |
US5221611A (en) * | 1991-06-19 | 1993-06-22 | Sigma Chemical Company | Ddi immunoassays, derivatives, conjugates and antibodies |
US5589587A (en) * | 1992-05-12 | 1996-12-31 | Merrell Pharmaceuticals Inc. | Process for the preparation of ribonucleotide reductase inhibitors |
CA2179987C (en) * | 1994-01-07 | 1999-01-19 | Richard E. Donaldson | Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine |
US7803786B2 (en) * | 2004-06-17 | 2010-09-28 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
EP2277878B1 (de) | 2008-04-10 | 2014-09-17 | Hamari Chemicals, Ltd. | Verfahren zur herstellung von ethynylthymidinverbindung mit 5-methyluridin als ausgangsrohmaterial |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62501712A (ja) * | 1985-08-26 | 1987-07-09 | アメリカ合衆国 | 2′、3′―ジデオキシイノシン、2′,3′―ジデオキシグアノシンまたは2′,3′―ジデオキシアデノシンを含有する抗htlv―3/lav剤 |
KR960001372B1 (ko) * | 1986-09-24 | 1996-01-26 | 예일 유니버시티 | 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질 |
US4978655A (en) * | 1986-12-17 | 1990-12-18 | Yale University | Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses |
CA1340645C (en) * | 1987-04-17 | 1999-07-13 | Victor E. Marquez | Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus |
IL89258A0 (en) * | 1988-02-16 | 1989-09-10 | Lilly Co Eli | 2',3'-dideoxy-2',2'-difluoro-nucleosides |
GB8823319D0 (en) * | 1988-10-05 | 1988-11-09 | Nycomed As | Chemical compounds |
-
1990
- 1990-05-11 FI FI902360A patent/FI95269C/fi active IP Right Grant
- 1990-05-14 DE DE69031962T patent/DE69031962T2/de not_active Expired - Fee Related
- 1990-05-14 IE IE173490A patent/IE81107B1/en not_active IP Right Cessation
- 1990-05-14 ES ES90109065T patent/ES2113851T3/es not_active Expired - Lifetime
- 1990-05-14 DK DK90109065T patent/DK0398230T3/da active
- 1990-05-14 EG EG28490A patent/EG19154A/xx active
- 1990-05-14 AT AT90109065T patent/ATE162528T1/de not_active IP Right Cessation
- 1990-05-14 KR KR1019900006857A patent/KR970001160B1/ko not_active IP Right Cessation
- 1990-05-14 BG BG92000A patent/BG60517B1/bg unknown
- 1990-05-14 AU AU55011/90A patent/AU617614B2/en not_active Ceased
- 1990-05-14 EP EP90109065A patent/EP0398230B1/de not_active Expired - Lifetime
- 1990-05-14 CN CN90103580A patent/CN1027896C/zh not_active Expired - Fee Related
- 1990-05-15 HU HU903038A patent/HU206628B/hu not_active IP Right Cessation
- 1990-05-15 PT PT94040A patent/PT94040B/pt not_active IP Right Cessation
- 1990-05-15 NO NO902148A patent/NO174102C/no unknown
-
1993
- 1993-09-22 NO NO933367A patent/NO176609C/no unknown
-
1994
- 1994-08-23 CN CN94116469A patent/CN1057443C/zh not_active Expired - Fee Related
-
1998
- 1998-01-22 GR GR970403458T patent/GR3025984T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69127336D1 (de) | Hydroxymethyl(methylencyclopentyl)Purinen und Pyrimidinen | |
BR9002976A (pt) | Composto heterociclico condensado,processo para preparar o mesmo,composicao fungicida e composto de acido carboxilico heterociclico condensado | |
ITMI921203A1 (it) | Derivati di s-triazina come agenti fotostabilizzanti | |
DK0471236T3 (da) | Imidazopyridinderivater og deres anvendelse | |
NO920210D0 (no) | Antivirale pyrimidinnukleosider | |
DE69005164T2 (de) | Acryloylsubstituierte Pyrrol-Derivate. | |
ES2046229T3 (es) | Composicion antiulcerosa. | |
DE69031962T2 (de) | Antivirale, gut wasserlösliche, stabile, kristalline Salze von 2',3'-Dideoxyinosinmonohydrat, 2',3'-Dideoxy-2',3'-didehydrothymidinmonohydrat und 2',3'-Dideoxy-2'-fluoroinosinhemihydrat | |
ES2093037T3 (es) | Derivados de beta-lactama y su preparacion. | |
ATE176230T1 (de) | Spiropyran-derivate mit photochromischen eigenschaften | |
MY116824A (en) | Antivaral,highly water soluble,stable,crystalline salts of 2'',3''-dideoxyinosine monohydrate,2'',3''-dideoxy-2'' ,3''-didehydrothymidine monohydrate and 2'',3''-dideoxy-2''-fluoroinosine hemihydrate | |
NO930284D0 (no) | Pyridinderivater, fremgangsmaate for deres fremstilling oganvendelse derav | |
DK0381114T3 (da) | Exo-3,4-O-benzyliden-3"-demethylchartreusin og salte deraf | |
TH8713EX (th) | ผลึกเกลือ 2',3'-ไดดีออกซิไอโนซีน โมโนไฮเดรท 2',3'-ไดดีออกซิ-2',3'-ไดดีไฮโดรไธมิดีนโมโนไฮเดรท และ 2',3'-ไดดีออกซิ-2'-ฟลูออโรไอโนซีน เฮมิไฮเดรทสำหรับต่อต้านไวรัสซึ่งละลายน้ำได้ดีและเสถียร |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |