BG92000A - Метод за получаване на соли на 2',3'-дидеоксиинозин монохидрат,2',3'-дидеокси-2',3'-дидехидротимидин моно- хидрат и 2',3'-дидеокси-2'-флуоринозин хемихидрат - Google Patents
Метод за получаване на соли на 2',3'-дидеоксиинозин монохидрат,2',3'-дидеокси-2',3'-дидехидротимидин моно- хидрат и 2',3'-дидеокси-2'-флуоринозин хемихидратInfo
- Publication number
- BG92000A BG92000A BG092000A BG9200090A BG92000A BG 92000 A BG92000 A BG 92000A BG 092000 A BG092000 A BG 092000A BG 9200090 A BG9200090 A BG 9200090A BG 92000 A BG92000 A BG 92000A
- Authority
- BG
- Bulgaria
- Prior art keywords
- dideoxy
- fluorinosine
- didehydrothymidine
- dideoxyinosine
- hemihydrate
- Prior art date
Links
- SLWSQPYUSBXANQ-BAJZRUMYSA-N 9-[(2r,3r,5s)-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound O1[C@H](CO)C[C@@H](F)[C@@H]1N1C(NC=NC2=O)=C2N=C1 SLWSQPYUSBXANQ-BAJZRUMYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- TYOLIMOHEMBOPU-UOERWJHTSA-N 9-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;hydrate Chemical class O.O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 TYOLIMOHEMBOPU-UOERWJHTSA-N 0.000 title 1
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000001767 cationic compounds Chemical group 0.000 abstract 1
- 229910001411 inorganic cation Chemical group 0.000 abstract 1
- 150000002892 organic cations Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Изобретението се отнася до високо водоразтворими устойчиви кристални соли на 2'3'-дидеокси-2',3'-дидехидротимидин с формула 2',3'-дидеоксиинозин с формула и 2',3'-дидеокси-2'-флуоринозин с формула където х е органичен или неорганичен катион, и до метод за получаването и за употребата им като антивирусни агенти. 1 претенция, 13 фигури
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35206589A | 1989-05-15 | 1989-05-15 | |
US51426190A | 1990-05-01 | 1990-05-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
BG92000A true BG92000A (bg) | 1993-12-24 |
BG60517B1 BG60517B1 (bg) | 1995-07-28 |
Family
ID=26997373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG92000A BG60517B1 (bg) | 1989-05-15 | 1990-05-14 | Метод за получаване на соли на 2',3'-дидеоксиинозин монохидрат,2',3'-дидеокси-2',3'-дидехидротимидин моно- хидрат и 2',3'-дидеокси-2'-флуоринозин хемихидрат |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0398230B1 (bg) |
KR (1) | KR970001160B1 (bg) |
CN (2) | CN1027896C (bg) |
AT (1) | ATE162528T1 (bg) |
AU (1) | AU617614B2 (bg) |
BG (1) | BG60517B1 (bg) |
DE (1) | DE69031962T2 (bg) |
DK (1) | DK0398230T3 (bg) |
EG (1) | EG19154A (bg) |
ES (1) | ES2113851T3 (bg) |
FI (1) | FI95269C (bg) |
GR (1) | GR3025984T3 (bg) |
HU (1) | HU206628B (bg) |
IE (1) | IE81107B1 (bg) |
NO (2) | NO174102C (bg) |
PT (1) | PT94040B (bg) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO920714L (no) * | 1991-03-01 | 1992-09-02 | Bristol Myers Squibb Co | Tetrahydrofuran-mellomprodukt |
US5221611A (en) * | 1991-06-19 | 1993-06-22 | Sigma Chemical Company | Ddi immunoassays, derivatives, conjugates and antibodies |
US5589587A (en) * | 1992-05-12 | 1996-12-31 | Merrell Pharmaceuticals Inc. | Process for the preparation of ribonucleotide reductase inhibitors |
ATE186732T1 (de) * | 1994-01-07 | 1999-12-15 | Merrell Pharma Inc | (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t |
US7803786B2 (en) * | 2004-06-17 | 2010-09-28 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
WO2009125841A1 (ja) | 2008-04-10 | 2009-10-15 | 浜理薬品工業株式会社 | 5-メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62501712A (ja) * | 1985-08-26 | 1987-07-09 | アメリカ合衆国 | 2′、3′―ジデオキシイノシン、2′,3′―ジデオキシグアノシンまたは2′,3′―ジデオキシアデノシンを含有する抗htlv―3/lav剤 |
KR960001372B1 (ko) * | 1986-09-24 | 1996-01-26 | 예일 유니버시티 | 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질 |
US4978655A (en) * | 1986-12-17 | 1990-12-18 | Yale University | Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses |
CA1340645C (en) * | 1987-04-17 | 1999-07-13 | Victor E. Marquez | Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus |
IL89258A0 (en) * | 1988-02-16 | 1989-09-10 | Lilly Co Eli | 2',3'-dideoxy-2',2'-difluoro-nucleosides |
GB8823319D0 (en) * | 1988-10-05 | 1988-11-09 | Nycomed As | Chemical compounds |
-
1990
- 1990-05-11 FI FI902360A patent/FI95269C/fi active IP Right Grant
- 1990-05-14 AU AU55011/90A patent/AU617614B2/en not_active Ceased
- 1990-05-14 IE IE173490A patent/IE81107B1/en not_active IP Right Cessation
- 1990-05-14 DK DK90109065T patent/DK0398230T3/da active
- 1990-05-14 EP EP90109065A patent/EP0398230B1/en not_active Expired - Lifetime
- 1990-05-14 CN CN90103580A patent/CN1027896C/zh not_active Expired - Fee Related
- 1990-05-14 ES ES90109065T patent/ES2113851T3/es not_active Expired - Lifetime
- 1990-05-14 EG EG28490A patent/EG19154A/xx active
- 1990-05-14 DE DE69031962T patent/DE69031962T2/de not_active Expired - Fee Related
- 1990-05-14 BG BG92000A patent/BG60517B1/bg unknown
- 1990-05-14 KR KR1019900006857A patent/KR970001160B1/ko not_active IP Right Cessation
- 1990-05-14 AT AT90109065T patent/ATE162528T1/de not_active IP Right Cessation
- 1990-05-15 HU HU903038A patent/HU206628B/hu not_active IP Right Cessation
- 1990-05-15 NO NO902148A patent/NO174102C/no unknown
- 1990-05-15 PT PT94040A patent/PT94040B/pt not_active IP Right Cessation
-
1993
- 1993-09-22 NO NO933367A patent/NO176609C/no unknown
-
1994
- 1994-08-23 CN CN94116469A patent/CN1057443C/zh not_active Expired - Fee Related
-
1998
- 1998-01-22 GR GR970403458T patent/GR3025984T3/el unknown
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