NO176609C - Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin - Google Patents

Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Info

Publication number
NO176609C
NO176609C NO933367A NO933367A NO176609C NO 176609 C NO176609 C NO 176609C NO 933367 A NO933367 A NO 933367A NO 933367 A NO933367 A NO 933367A NO 176609 C NO176609 C NO 176609C
Authority
NO
Norway
Prior art keywords
dideoxy
stable
hydrothymidine
fluorinosine
deideoxy
Prior art date
Application number
NO933367A
Other languages
English (en)
Other versions
NO176609B (no
NO933367L (no
NO933367D0 (no
Inventor
Murray Arthur Kaplan
Robert Kevin Perrone
Joseph Ballard Bogardus
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO933367L publication Critical patent/NO933367L/no
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to NO933367A priority Critical patent/NO176609C/no
Publication of NO933367D0 publication Critical patent/NO933367D0/no
Publication of NO176609B publication Critical patent/NO176609B/no
Publication of NO176609C publication Critical patent/NO176609C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
NO933367A 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin NO176609C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01
NO902148A NO174102C (no) 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Publications (4)

Publication Number Publication Date
NO933367L NO933367L (no) 1990-11-16
NO933367D0 NO933367D0 (no) 1993-09-22
NO176609B NO176609B (no) 1995-01-23
NO176609C true NO176609C (no) 1995-05-03

Family

ID=26997373

Family Applications (2)

Application Number Title Priority Date Filing Date
NO902148A NO174102C (no) 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no) 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO902148A NO174102C (no) 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat

Country Status (16)

Country Link
EP (1) EP0398230B1 (no)
KR (1) KR970001160B1 (no)
CN (2) CN1027896C (no)
AT (1) ATE162528T1 (no)
AU (1) AU617614B2 (no)
BG (1) BG60517B1 (no)
DE (1) DE69031962T2 (no)
DK (1) DK0398230T3 (no)
EG (1) EG19154A (no)
ES (1) ES2113851T3 (no)
FI (1) FI95269C (no)
GR (1) GR3025984T3 (no)
HU (1) HU206628B (no)
IE (1) IE81107B1 (no)
NO (2) NO174102C (no)
PT (1) PT94040B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
CA2179987C (en) * 1994-01-07 1999-01-19 Richard E. Donaldson Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
US7803786B2 (en) * 2004-06-17 2010-09-28 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions and related methods of use
EP2277878B1 (en) 2008-04-10 2014-09-17 Hamari Chemicals, Ltd. Process for production of ethynylthymidine compound using 5-methyluridine as starting raw material

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62501712A (ja) * 1985-08-26 1987-07-09 アメリカ合衆国 ２′、３′―ジデオキシイノシン、２′，３′―ジデオキシグアノシンまたは２′，３′―ジデオキシアデノシンを含有する抗ｈｔｌｖ―３／ｌａｖ剤
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
IL89258A0 (en) * 1988-02-16 1989-09-10 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoro-nucleosides
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
NO176609B (no) 1995-01-23
EP0398230A3 (en) 1991-06-26
AU5501190A (en) 1990-11-15
CN1047676A (zh) 1990-12-12
DE69031962D1 (de) 1998-02-26
FI902360A0 (fi) 1990-05-11
HU206628B (en) 1992-12-28
PT94040A (pt) 1991-01-08
AU617614B2 (en) 1991-11-28
FI95269B (fi) 1995-09-29
IE81107B1 (en) 2000-03-08
KR970001160B1 (ko) 1997-01-29
PT94040B (pt) 1996-12-31
HU903038D0 (en) 1990-09-28
KR900017591A (ko) 1990-12-19
NO174102C (no) 1994-03-16
HUT53528A (en) 1990-11-28
NO933367L (no) 1990-11-16
CN1027896C (zh) 1995-03-15
NO902148L (no) 1990-11-16
NO174102B (no) 1993-12-06
NO933367D0 (no) 1993-09-22
CN1057443C (zh) 2000-10-18
BG92000A (bg) 1993-12-24
DK0398230T3 (da) 1998-09-21
CN1109755A (zh) 1995-10-11
DE69031962T2 (de) 1998-09-17
EP0398230B1 (en) 1998-01-21
FI95269C (fi) 1996-01-10
IE901734L (en) 1990-11-15
EP0398230A2 (en) 1990-11-22
EG19154A (en) 1994-09-29
GR3025984T3 (en) 1998-04-30
BG60517B1 (bg) 1995-07-28
ATE162528T1 (de) 1998-02-15
NO902148D0 (no) 1990-05-15
ES2113851T3 (es) 1998-05-16

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