ATE162528T1 - Antivirale, gut wasserlösliche, stabile, kristalline salze von 2',3'- dideoxyinosinmonohydrat, 2',3'-dideoxy-2',3'- didehydrothymidinmonohydrat und 2',3'-dideoxy-2'- fluoroinosinhemihydrat - Google Patents

Antivirale, gut wasserlösliche, stabile, kristalline salze von 2',3'- dideoxyinosinmonohydrat, 2',3'-dideoxy-2',3'- didehydrothymidinmonohydrat und 2',3'-dideoxy-2'- fluoroinosinhemihydrat

Info

Publication number
ATE162528T1
ATE162528T1 AT90109065T AT90109065T ATE162528T1 AT E162528 T1 ATE162528 T1 AT E162528T1 AT 90109065 T AT90109065 T AT 90109065T AT 90109065 T AT90109065 T AT 90109065T AT E162528 T1 ATE162528 T1 AT E162528T1
Authority
AT
Austria
Prior art keywords
dideoxy
monohydrate
fluoroinosine
didehydrothymidine
dideoxyinosine
Prior art date
Application number
AT90109065T
Other languages
English (en)
Inventor
Murray Arthur Kaplan
Robert Kevin Perrone
Joseph Ballard Bogardus
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE162528T1 publication Critical patent/ATE162528T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
AT90109065T 1989-05-15 1990-05-14 Antivirale, gut wasserlösliche, stabile, kristalline salze von 2',3'- dideoxyinosinmonohydrat, 2',3'-dideoxy-2',3'- didehydrothymidinmonohydrat und 2',3'-dideoxy-2'- fluoroinosinhemihydrat ATE162528T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01

Publications (1)

Publication Number Publication Date
ATE162528T1 true ATE162528T1 (de) 1998-02-15

Family

ID=26997373

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90109065T ATE162528T1 (de) 1989-05-15 1990-05-14 Antivirale, gut wasserlösliche, stabile, kristalline salze von 2',3'- dideoxyinosinmonohydrat, 2',3'-dideoxy-2',3'- didehydrothymidinmonohydrat und 2',3'-dideoxy-2'- fluoroinosinhemihydrat

Country Status (16)

Country Link
EP (1) EP0398230B1 (de)
KR (1) KR970001160B1 (de)
CN (2) CN1027896C (de)
AT (1) ATE162528T1 (de)
AU (1) AU617614B2 (de)
BG (1) BG60517B1 (de)
DE (1) DE69031962T2 (de)
DK (1) DK0398230T3 (de)
EG (1) EG19154A (de)
ES (1) ES2113851T3 (de)
FI (1) FI95269C (de)
GR (1) GR3025984T3 (de)
HU (1) HU206628B (de)
IE (1) IE81107B1 (de)
NO (2) NO174102C (de)
PT (1) PT94040B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
ATE186732T1 (de) * 1994-01-07 1999-12-15 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
US7803786B2 (en) * 2004-06-17 2010-09-28 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions and related methods of use
WO2009125841A1 (ja) 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62501712A (ja) * 1985-08-26 1987-07-09 アメリカ合衆国 ２′、３′―ジデオキシイノシン、２′，３′―ジデオキシグアノシンまたは２′，３′―ジデオキシアデノシンを含有する抗ｈｔｌｖ―３／ｌａｖ剤
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
IL89258A0 (en) * 1988-02-16 1989-09-10 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoro-nucleosides
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
EP0398230A2 (de) 1990-11-22
CN1109755A (zh) 1995-10-11
NO176609B (no) 1995-01-23
DE69031962D1 (de) 1998-02-26
HU903038D0 (en) 1990-09-28
ES2113851T3 (es) 1998-05-16
NO176609C (no) 1995-05-03
BG60517B1 (bg) 1995-07-28
NO933367D0 (no) 1993-09-22
EP0398230B1 (de) 1998-01-21
BG92000A (bg) 1993-12-24
IE81107B1 (en) 2000-03-08
EP0398230A3 (de) 1991-06-26
HUT53528A (en) 1990-11-28
KR970001160B1 (ko) 1997-01-29
AU5501190A (en) 1990-11-15
PT94040A (pt) 1991-01-08
PT94040B (pt) 1996-12-31
DE69031962T2 (de) 1998-09-17
CN1057443C (zh) 2000-10-18
DK0398230T3 (da) 1998-09-21
IE901734L (en) 1990-11-15
KR900017591A (ko) 1990-12-19
NO933367L (no) 1990-11-16
GR3025984T3 (en) 1998-04-30
NO174102C (no) 1994-03-16
FI95269B (fi) 1995-09-29
CN1027896C (zh) 1995-03-15
FI902360A0 (fi) 1990-05-11
EG19154A (en) 1994-09-29
CN1047676A (zh) 1990-12-12
AU617614B2 (en) 1991-11-28
NO902148D0 (no) 1990-05-15
FI95269C (fi) 1996-01-10
NO902148L (no) 1990-11-16
NO174102B (no) 1993-12-06
HU206628B (en) 1992-12-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee