EG19154A - Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate - Google Patents

Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate

Info

Publication number
EG19154A
EG19154A EG28490A EG28490A EG19154A EG 19154 A EG19154 A EG 19154A EG 28490 A EG28490 A EG 28490A EG 28490 A EG28490 A EG 28490A EG 19154 A EG19154 A EG 19154A
Authority
EG
Egypt
Prior art keywords
dideoxy
monohydrate
salts
fluoroinosine
dideoxyinosine
Prior art date
Application number
EG28490A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of EG19154A publication Critical patent/EG19154A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
EG28490A 1989-05-15 1990-05-14 Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate EG19154A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35206589A 1989-05-15 1989-05-15
US51426190A 1990-05-01 1990-05-01

Publications (1)

Publication Number Publication Date
EG19154A true EG19154A (en) 1994-09-29

Family

ID=26997373

Family Applications (1)

Application Number Title Priority Date Filing Date
EG28490A EG19154A (en) 1989-05-15 1990-05-14 Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate

Country Status (16)

Country Link
EP (1) EP0398230B1 (pt)
KR (1) KR970001160B1 (pt)
CN (2) CN1027896C (pt)
AT (1) ATE162528T1 (pt)
AU (1) AU617614B2 (pt)
BG (1) BG60517B1 (pt)
DE (1) DE69031962T2 (pt)
DK (1) DK0398230T3 (pt)
EG (1) EG19154A (pt)
ES (1) ES2113851T3 (pt)
FI (1) FI95269C (pt)
GR (1) GR3025984T3 (pt)
HU (1) HU206628B (pt)
IE (1) IE81107B1 (pt)
NO (2) NO174102C (pt)
PT (1) PT94040B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO920714L (no) * 1991-03-01 1992-09-02 Bristol Myers Squibb Co Tetrahydrofuran-mellomprodukt
US5221611A (en) * 1991-06-19 1993-06-22 Sigma Chemical Company Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
NZ279030A (en) * 1994-01-07 1997-05-26 Merrell Pharma Inc 2'-deoxy-2'-(fluoromethylene)cytidine
JP5017103B2 (ja) * 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 薬剤共結晶組成物および関連した使用方法
US8445669B2 (en) 2008-04-10 2013-05-21 Hamari Chemicals, Ltd. Production process of ethynylthymidine compounds from 5-methyluridine as a starting material

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Also Published As

Publication number Publication date
NO176609B (no) 1995-01-23
NO902148L (no) 1990-11-16
ES2113851T3 (es) 1998-05-16
BG60517B1 (bg) 1995-07-28
KR970001160B1 (ko) 1997-01-29
PT94040B (pt) 1996-12-31
PT94040A (pt) 1991-01-08
EP0398230B1 (en) 1998-01-21
ATE162528T1 (de) 1998-02-15
EP0398230A2 (en) 1990-11-22
FI95269B (fi) 1995-09-29
EP0398230A3 (en) 1991-06-26
FI95269C (fi) 1996-01-10
DK0398230T3 (da) 1998-09-21
NO933367D0 (no) 1993-09-22
IE901734L (en) 1990-11-15
GR3025984T3 (en) 1998-04-30
NO902148D0 (no) 1990-05-15
CN1047676A (zh) 1990-12-12
DE69031962D1 (de) 1998-02-26
DE69031962T2 (de) 1998-09-17
IE81107B1 (en) 2000-03-08
CN1027896C (zh) 1995-03-15
CN1109755A (zh) 1995-10-11
NO174102C (no) 1994-03-16
AU617614B2 (en) 1991-11-28
FI902360A0 (fi) 1990-05-11
BG92000A (bg) 1993-12-24
CN1057443C (zh) 2000-10-18
HU206628B (en) 1992-12-28
NO933367L (no) 1990-11-16
NO174102B (no) 1993-12-06
KR900017591A (ko) 1990-12-19
HU903038D0 (en) 1990-09-28
HUT53528A (en) 1990-11-28
AU5501190A (en) 1990-11-15
NO176609C (no) 1995-05-03

Similar Documents

Publication Publication Date Title
PL292101A1 (en) Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
ZA944739B (en) Amide and urea derivatives having anti-hypercholesteremic activity their preparation and their therapeutic uses
IL90271A0 (en) Antiviral drug
GR3004139T3 (pt)
GR852758B (pt)
HK1012341A1 (en) Pyrrolocarbazole
GB8607921D0 (en) 3,4-disubstituted-2-azetidinone derivatives
EP0314098A3 (en) Imide derivatives, their production and use
GR3007460T3 (pt)
EG19154A (en) Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate
EP0285284A3 (en) N-phenethylaminoalkyl-benzamide anti-arrhythmia agents
MY116824A (en) Antivaral,highly water soluble,stable,crystalline salts of 2'',3''-dideoxyinosine monohydrate,2'',3''-dideoxy-2'' ,3''-didehydrothymidine monohydrate and 2'',3''-dideoxy-2''-fluoroinosine hemihydrate
GR3006108T3 (pt)
EP0421668A3 (en) 1,4-dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents
HUT38607A (en) Process for producing phenyl-ethyl-amino-propiophenone derivatives and pharmaceutical composition containing them as active agents
EP0381114A3 (en) Exo-3',4'-0-benzylidene-3"-demethylchartreusin and its salts
EP0272849A3 (en) Use of 2-oxo-imidazolidine derivatives in the treatment of kidney diseases
TH8713EX (th) ผลึกเกลือ 2',3'-ไดดีออกซิไอโนซีน โมโนไฮเดรท 2',3'-ไดดีออกซิ-2',3'-ไดดีไฮโดรไธมิดีนโมโนไฮเดรท และ 2',3'-ไดดีออกซิ-2'-ฟลูออโรไอโนซีน เฮมิไฮเดรทสำหรับต่อต้านไวรัสซึ่งละลายน้ำได้ดีและเสถียร