PT923570E - Amidas de acidos piridil-alcenoicos e piridil-alcinicos como agentes citostaticos e imunossupressivos - Google Patents
Amidas de acidos piridil-alcenoicos e piridil-alcinicos como agentes citostaticos e imunossupressivosInfo
- Publication number
- PT923570E PT923570E PT97928261T PT97928261T PT923570E PT 923570 E PT923570 E PT 923570E PT 97928261 T PT97928261 T PT 97928261T PT 97928261 T PT97928261 T PT 97928261T PT 923570 E PT923570 E PT 923570E
- Authority
- PT
- Portugal
- Prior art keywords
- pyridyl
- citostatic
- alcinic
- alcenoic
- amides
- Prior art date
Links
- 230000001506 immunosuppresive effect Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- -1 pyridyl alkene Chemical class 0.000 abstract 2
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19624659A DE19624659A1 (de) | 1996-06-20 | 1996-06-20 | Neue Pyridylalken- und Pyridylalkinsäureamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT923570E true PT923570E (pt) | 2002-12-31 |
Family
ID=7797501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97928261T PT923570E (pt) | 1996-06-20 | 1997-06-20 | Amidas de acidos piridil-alcenoicos e piridil-alcinicos como agentes citostaticos e imunossupressivos |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US7241745B2 (OSRAM) |
| EP (1) | EP0923570B1 (OSRAM) |
| JP (1) | JP4225572B2 (OSRAM) |
| CN (2) | CN1152032C (OSRAM) |
| AT (1) | ATE224888T1 (OSRAM) |
| AU (1) | AU736206B2 (OSRAM) |
| BR (1) | BR9709823B1 (OSRAM) |
| CA (1) | CA2257448C (OSRAM) |
| CZ (1) | CZ291791B6 (OSRAM) |
| DE (2) | DE19624659A1 (OSRAM) |
| DK (1) | DK0923570T3 (OSRAM) |
| ES (1) | ES2179351T3 (OSRAM) |
| HU (1) | HU225715B1 (OSRAM) |
| IL (1) | IL127352A (OSRAM) |
| PT (1) | PT923570E (OSRAM) |
| RU (1) | RU2200734C2 (OSRAM) |
| TR (1) | TR199802651T2 (OSRAM) |
| WO (1) | WO1997048696A1 (OSRAM) |
| ZA (1) | ZA975437B (OSRAM) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE19756236A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
| DE19756212A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
| DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| DE19756261A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
| DE19818044A1 (de) * | 1998-04-22 | 1999-10-28 | Klinge Co Chem Pharm Fab | Verwendung von Vitamin-PP-Verbindungen |
| BR9915403A (pt) * | 1998-11-17 | 2001-08-14 | Hoffmann La Roche | Antagonistas receptores iii de 4-aroil-piperidin-ccr-3 |
| EP1031564A1 (en) * | 1999-02-26 | 2000-08-30 | Klinge Pharma GmbH | Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy |
| US6432432B1 (en) | 1999-03-05 | 2002-08-13 | Arch Chemicals, Inc. | Chemical method of making a suspension, emulsion or dispersion of pyrithione particles |
| CO5180550A1 (es) | 1999-04-19 | 2002-07-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| CO5370679A1 (es) | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| US6730684B1 (en) | 1999-10-08 | 2004-05-04 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| PE20010635A1 (es) | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
| US6762201B1 (en) | 1999-10-08 | 2004-07-13 | Affinium Pharmaceuticals, Inc. | Fab I inhibitors |
| DK1560584T3 (da) | 2001-04-06 | 2009-05-18 | Affinium Pharm Inc | Fab I inhibitorer |
| FR2823975B1 (fr) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | Nouvelle utilisation de pyridoindolone |
| EP1348434A1 (en) * | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
| PT1599468E (pt) | 2003-01-14 | 2008-01-14 | Arena Pharm Inc | Derivados de arilo e heteroarilo 1,2,3.-trissubstituídos comomoduladores do metabolismo, e profilaxia e tratamento dedesordens relacionadas tais como diabetes e hiperglicemia |
| EP2583678A3 (en) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
| US20110045065A1 (en) * | 2005-07-11 | 2011-02-24 | Ashok Vasantray Vyas | Substance having antioxidant, geroprotective and anti-ischemic activity and method for the preparation thereof |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| WO2008009122A1 (en) | 2006-07-20 | 2008-01-24 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as fab i inhibitors |
| WO2008026018A1 (en) | 2006-09-01 | 2008-03-06 | Topotarget Switzerland Sa | New method for the treatment of inflammatory diseases |
| WO2008098374A1 (en) | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| EP2098231A1 (en) | 2008-03-05 | 2009-09-09 | Topotarget Switzerland SA | Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury |
| CN102123988B (zh) | 2008-06-24 | 2013-08-14 | 顶标公司 | 作为烟酰胺抑制剂的方酸衍生物 |
| RU2011111728A (ru) | 2008-08-29 | 2012-10-10 | Топотаргет А/С (Dk) | Новые производные мочевины и тиомочевины |
| CN102421754B (zh) * | 2009-05-12 | 2013-11-27 | 北京世桥生物制药有限公司 | 丙烯酰胺类衍生物及其制备药物的用途 |
| CA2768338A1 (en) | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| JP5881705B2 (ja) | 2010-09-03 | 2016-03-09 | フォーマ ティーエム， エルエルシー． | Ｎａｍｐｔの阻害のための新規化合物及び組成物 |
| KR20130114119A (ko) | 2010-09-03 | 2013-10-16 | 포르마 티엠, 엘엘씨. | Ｎａｍｐｔ의 억제를 위한 신규 화합물 및 조성물 |
| CN106986856A (zh) | 2010-09-03 | 2017-07-28 | 福马Tm有限责任公司 | 作为用于治疗疾病诸如癌症的nampt抑制剂的4‑{[(吡啶‑3‑基‑甲基)氨基羰基]氨基}苯‑砜衍生物 |
| JP5941916B2 (ja) | 2010-09-22 | 2016-06-29 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置 |
| AR083200A1 (es) * | 2010-09-29 | 2013-02-06 | Intervet Int Bv | Compuestos de n-heteroarilo |
| WO2012067963A1 (en) | 2010-11-15 | 2012-05-24 | Abbott Laboratories | Nampt inhibitors |
| AR083855A1 (es) | 2010-11-15 | 2013-03-27 | Abbott Lab | Inhibidores de nampt y rock |
| AU2011367222B2 (en) | 2011-05-04 | 2017-04-13 | Forma Tm, Llc | Novel compounds and compositions for the inhibition of NAMPT |
| TW201245188A (en) | 2011-05-09 | 2012-11-16 | Forma Therapeutics Inc | Novel compounds and compositions for the inhibition of NAMPT |
| PL2736887T3 (pl) | 2011-07-29 | 2018-03-30 | Karyopharm Therapeutics, Inc. | Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania |
| PT2858991T (pt) | 2012-05-09 | 2018-12-17 | Biogen Ma Inc | Moduladores do transporte nuclear e usos dos mesmos |
| US8975398B2 (en) | 2012-05-11 | 2015-03-10 | Abbvie Inc. | NAMPT inhibitors |
| EP2852585A1 (en) | 2012-05-11 | 2015-04-01 | AbbVie Inc. | Nampt inhibitors |
| CA2870566A1 (en) | 2012-05-11 | 2013-11-14 | Abbvie Inc. | Thiazolecarboxamide derivatives for use as nampt inhibitors |
| MX2014013734A (es) | 2012-05-11 | 2015-06-10 | Abbvie Inc | Inhibidores de nampt. |
| NZ702695A (en) | 2012-06-19 | 2015-10-30 | Debiopharm Int Sa | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| US9938258B2 (en) | 2012-11-29 | 2018-04-10 | Karyopharm Therapeutics Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
| WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| RS58581B1 (sr) | 2013-06-21 | 2019-05-31 | Karyopharm Therapeutics Inc | 1,2,4-triazoli kao modulatori jedarnog transporta i njihova primena |
| US9856241B2 (en) * | 2013-07-03 | 2018-01-02 | Karyopharm Therapeutics Inc. | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof |
| WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
| EP3055304A1 (en) * | 2013-10-09 | 2016-08-17 | Eli Lilly and Company | Novel pyridyloxyacetyl tetrahydroisoquinoline compounds useful as nampt inhibitors |
| CN106661013A (zh) | 2014-07-23 | 2017-05-10 | 奥瑞基尼探索技术有限公司 | 用作nampt抑制剂的4，5‑二氢异噁唑衍生物 |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| CN104447483B (zh) * | 2015-01-13 | 2016-07-27 | 佛山市赛维斯医药科技有限公司 | 含苯胺和二烯金刚烷结构的化合物、其制备方法和用途 |
| CN104447484B (zh) * | 2015-01-13 | 2016-06-08 | 佛山市赛维斯医药科技有限公司 | 含烷氧苯基和二烯金刚烷结构的化合物、其制备方法和用途 |
| CN104447486B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 二烯氟代金刚烷类化合物、其制备方法和用途 |
| DK3310760T3 (da) | 2015-06-22 | 2022-10-24 | Arena Pharm Inc | Krystallinsk L-argininsalt af (R)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3- yl)eddikesyre til anvendelse ved S1P1-receptor-associerede lidelser |
| JP2018528196A (ja) | 2015-08-18 | 2018-09-27 | カリオファーム セラピューティクス，インコーポレイテッド | 癌の治療のための（ｓ，ｅ）−３−（６−アミノピリジン−３−イル）−ｎ−（（５−（４−（３−フルオロ−３−メチルピロリジン−１−カルボニル）フェニル）−７−（４−フルオロフェニル）ベンゾフラン−２−イル）メチル）アクリルアミド |
| TW201720802A (zh) * | 2015-09-15 | 2017-06-16 | 艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| WO2017117447A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| ES2842443T3 (es) | 2016-02-26 | 2021-07-14 | Debiopharm Int Sa | Medicamento para el tratamiento de infecciones del pie diabético |
| EP3279192A1 (en) | 2016-08-05 | 2018-02-07 | Centre Hospitalier Universitaire Vaudois (CHUV) | Piperidine derivatives for use in the treatment of pancreatic cancer |
| WO2018086703A1 (en) | 2016-11-11 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Dihydropyridazinones substituted with phenylureas |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| CN107827897A (zh) * | 2017-10-23 | 2018-03-23 | 青岛大学 | 一种手性七元螺环吲哚酮类化合物的合成方法 |
| CA3089754A1 (en) | 2018-01-31 | 2019-08-08 | Bayer Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
| CN108558840B (zh) * | 2018-06-04 | 2020-11-06 | 上海交通大学 | 水溶性氮杂α-萘黄酮类化合物及其制备方法和医药用途 |
| BR112020024762A2 (pt) | 2018-06-06 | 2021-03-23 | Arena Pharmaceuticals, Inc. | métodos de tratamento de condições relacionadas ao receptor s1p1 |
| IL285204B2 (en) | 2019-02-14 | 2025-02-01 | Debiopharm Int Sa | Formulation of apavicin, method for its preparation |
| EP3982975A1 (en) | 2019-06-14 | 2022-04-20 | Debiopharm International SA | Afabicin for use for treating bacterial infections involving biofilm |
| WO2021013693A1 (en) | 2019-07-23 | 2021-01-28 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) with nampt inhibitors |
| KR20220110744A (ko) | 2019-11-06 | 2022-08-09 | 레미디 플랜, 인크. | 암 줄기 세포를 표적화하는 암 치료 |
| JP2024518089A (ja) | 2021-05-13 | 2024-04-24 | リメディー プラン，インコーポレーテッド | Ｎａｍｐｔ阻害剤とその使用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283541A (en) | 1980-05-27 | 1981-08-11 | Usv Pharmaceutical Corporation | Pyridylacyl-hydroxamates |
| NL8005133A (nl) | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| US5326772A (en) | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
| US4778796A (en) | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE3641822A1 (de) | 1986-12-06 | 1988-06-16 | Goedecke Ag | Verwendung von dihydrophenylaminosaeurederivaten und diese enthaltende arzneimittel zur immunmodulation und cytostase |
| JPS63179869A (ja) | 1987-01-20 | 1988-07-23 | Dainippon Pharmaceut Co Ltd | ピペリジン誘導体 |
| JP2832979B2 (ja) * | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
| HU206181B (en) | 1988-02-19 | 1992-09-28 | Byk Gulden Lomberg Chem Fab | Process for producing pharmaceutical compositions comprising optically pure r-(+)-niguldipin and its derivatives and suitable for treating tumoros diseases |
| EP0343307A1 (en) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinealkanamine derivatives |
| IE903196A1 (en) | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
| US5125957A (en) * | 1989-11-01 | 1992-06-30 | Sumitomo Chemical Company, Limited | Pyrimidine derivatives |
| IE903957A1 (en) | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| AU7652391A (en) | 1990-04-10 | 1991-10-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyridine esters |
| JPH05506216A (ja) | 1990-04-10 | 1993-09-16 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 医薬としてのピリジン |
| US5260323A (en) | 1990-06-28 | 1993-11-09 | Hoechst Aktiengesellschaft | 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use |
| DE4020570A1 (de) | 1990-06-28 | 1992-01-02 | Hoechst Ag | 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung |
| US5244908A (en) | 1990-07-30 | 1993-09-14 | Takeda Chemical Industries, Ltd. | Imidazopyridine derivatives and their pharmaceutical use |
| US5229400A (en) | 1990-10-05 | 1993-07-20 | Ajinomoto Co., Inc. | Piperidine compounds and their use as antiarrhythmic agents |
| FR2676053B1 (fr) | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| EP0612729B1 (en) | 1991-05-10 | 1997-04-23 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, their production and use |
| US5208247A (en) | 1991-08-01 | 1993-05-04 | American Cyanamid Company | Pyridinium compounds which are useful as antagonists of platelet activating factor |
| EP0548883A1 (de) | 1991-12-24 | 1993-06-30 | Hoechst Aktiengesellschaft | Substituierte Pyridin-N-oxide, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| US5622976A (en) | 1991-12-31 | 1997-04-22 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
| GB9200535D0 (en) | 1992-01-10 | 1992-02-26 | Fujisawa Pharmaceutical Co | New compound |
| FR2686084B1 (fr) | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| US5612336A (en) | 1992-07-13 | 1997-03-18 | Merck, Sharp & Dohme Ltd. | Heterocyclic amide derivatives as tachykinin antagonists |
| IL111257A0 (en) | 1993-10-15 | 1994-12-29 | Schering Corp | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL111235A (en) | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| AU699043B2 (en) | 1993-10-15 | 1998-11-19 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| EP0750496A1 (en) | 1994-03-14 | 1997-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents |
| IL117798A (en) | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| FR2738245B1 (fr) | 1995-08-28 | 1997-11-21 | Sanofi Sa | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| US6451816B1 (en) * | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| DE19624668A1 (de) | 1996-06-20 | 1998-02-19 | Klinge Co Chem Pharm Fab | Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden |
| DE19624704A1 (de) | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalkansäureamide |
-
1996
- 1996-06-20 DE DE19624659A patent/DE19624659A1/de not_active Ceased
-
1997
- 1997-06-19 ZA ZA9705437A patent/ZA975437B/xx unknown
- 1997-06-20 CA CA002257448A patent/CA2257448C/en not_active Expired - Fee Related
- 1997-06-20 TR TR1998/02651T patent/TR199802651T2/xx unknown
- 1997-06-20 PT PT97928261T patent/PT923570E/pt unknown
- 1997-06-20 CN CNB971974241A patent/CN1152032C/zh not_active Expired - Fee Related
- 1997-06-20 AU AU32625/97A patent/AU736206B2/en not_active Ceased
- 1997-06-20 CN CNA2004100325866A patent/CN1546472A/zh active Pending
- 1997-06-20 EP EP97928261A patent/EP0923570B1/en not_active Expired - Lifetime
- 1997-06-20 DE DE69715888T patent/DE69715888T2/de not_active Expired - Lifetime
- 1997-06-20 JP JP50231898A patent/JP4225572B2/ja not_active Expired - Fee Related
- 1997-06-20 IL IL12735297A patent/IL127352A/xx not_active IP Right Cessation
- 1997-06-20 CZ CZ19984093A patent/CZ291791B6/cs not_active IP Right Cessation
- 1997-06-20 ES ES97928261T patent/ES2179351T3/es not_active Expired - Lifetime
- 1997-06-20 BR BRPI9709823-0B1A patent/BR9709823B1/pt not_active IP Right Cessation
- 1997-06-20 DK DK97928261T patent/DK0923570T3/da active
- 1997-06-20 RU RU99101069/04A patent/RU2200734C2/ru not_active IP Right Cessation
- 1997-06-20 HU HU9903766A patent/HU225715B1/hu not_active IP Right Cessation
- 1997-06-20 WO PCT/EP1997/003245 patent/WO1997048696A1/en not_active Ceased
- 1997-06-20 AT AT97928261T patent/ATE224888T1/de active
-
2002
- 2002-08-05 US US10/213,952 patent/US7241745B2/en not_active Expired - Fee Related
-
2006
- 2006-12-07 US US11/635,157 patent/US20070219197A1/en not_active Abandoned
-
2007
- 2007-02-26 US US11/678,980 patent/US20070142377A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT923570E (pt) | Amidas de acidos piridil-alcenoicos e piridil-alcinicos como agentes citostaticos e imunossupressivos | |
| PT934309E (pt) | Novas piridil-alcano-amidas como agentes citostaticos e imunossupressivos | |
| ZA975443B (en) | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides. | |
| DK1060163T3 (da) | Nye piperazinyl-substituerede pyridylalkan-, -alken og -alkyncarboxamider | |
| MY133647A (en) | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | |
| TR200200068T2 (tr) | Nematisital triflüorobütenler | |
| PT1044197E (pt) | Carboxamidas de piridilalcano, -alceno e -alcino substituidas por piperidinilo como agentes citostaticos e imunossupressores | |
| PT1042291E (pt) | Piridilalcano, alceno e alcino carboxamidas substituidas com arilo, uteis como agentes citostaticos e imunossupressores | |
| AR007828A1 (es) | Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos | |
| DE60220525D1 (de) | Pyrazolo-pyridine für die behandlung von herpes-ansteckungen | |
| TR199901949T2 (xx) | Lemfositik t�m�rler i�in �areler. | |
| ATE188873T1 (de) | Tris-platin-komplexe | |
| DK0952853T3 (da) | Konjugat omfattende et aktivt middel, et polypeptid og en polyether | |
| AR002272A1 (es) | Uso de amidas de fenilciclohexilcarboxilicos | |
| DE69818823D1 (de) | Dipohosphonsäuresalze für die behandlung von osteoporose | |
| ES2082212T3 (es) | Nuevos inhibidores de alfa-glucosidasa. | |
| SE9803107D0 (sv) | Novel Compunds | |
| DE69807200D1 (de) | Inklusionskomplexe in waessriger loesung | |
| TR200000916T2 (tr) | İkameli piperidin türevleri. | |
| ATE221068T1 (de) | Anellierte beta-carboline | |
| ES8106493A1 (es) | Nuevo procedimiento para la obtencion de n(25-3-mercapto-2- metil-propanoil)-l-prolina. |