DE69818823D1 - Dipohosphonsäuresalze für die behandlung von osteoporose - Google Patents
Dipohosphonsäuresalze für die behandlung von osteoporoseInfo
- Publication number
- DE69818823D1 DE69818823D1 DE69818823T DE69818823T DE69818823D1 DE 69818823 D1 DE69818823 D1 DE 69818823D1 DE 69818823 T DE69818823 T DE 69818823T DE 69818823 T DE69818823 T DE 69818823T DE 69818823 D1 DE69818823 D1 DE 69818823D1
- Authority
- DE
- Germany
- Prior art keywords
- osteoporosis
- dipohosphonic
- treatment
- acid salts
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3839—Polyphosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI971628 | 1997-07-09 | ||
IT97MI001628A IT1293305B1 (it) | 1997-07-09 | 1997-07-09 | Sali di acidi difosfonici e loro impiego farmacologico nel trattamento dell'osteoporosi |
PCT/EP1998/004238 WO1999002539A1 (en) | 1997-07-09 | 1998-07-08 | Diphosphonic acid salts for the treatment of osteoporosis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69818823D1 true DE69818823D1 (de) | 2003-11-13 |
DE69818823T2 DE69818823T2 (de) | 2004-05-06 |
Family
ID=11377528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69818823T Expired - Fee Related DE69818823T2 (de) | 1997-07-09 | 1998-07-08 | Dipohosphonsäuresalze für die behandlung von osteoporose |
Country Status (17)
Country | Link |
---|---|
US (1) | US6410782B1 (de) |
EP (1) | EP0994884B1 (de) |
JP (1) | JP3681637B2 (de) |
KR (1) | KR100396036B1 (de) |
CN (1) | CN1161363C (de) |
AT (1) | ATE251631T1 (de) |
AU (1) | AU8806798A (de) |
BR (1) | BR9810561A (de) |
CA (1) | CA2303210A1 (de) |
DE (1) | DE69818823T2 (de) |
DK (1) | DK0994884T3 (de) |
ES (1) | ES2207853T3 (de) |
HU (1) | HUP0004679A3 (de) |
IL (1) | IL133172A (de) |
IT (1) | IT1293305B1 (de) |
PT (1) | PT994884E (de) |
WO (1) | WO1999002539A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100317935B1 (ko) * | 1999-10-20 | 2001-12-22 | 유승필 | 대사성 골질환 치료용 약제조성물 및 이의 제조방법 |
US20080269184A1 (en) * | 2004-03-04 | 2008-10-30 | Makoto Yuasa | Niosome Having Metal Porphyrin Complex Embedded Therein, Process For Producing The Same And Drug With The Use Thereof |
US20080286359A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
US20080287400A1 (en) | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US7645460B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of risedronate |
FR2926081B1 (fr) * | 2008-01-03 | 2010-02-19 | Univ Nantes | Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux |
EP2266578A4 (de) * | 2008-03-18 | 2011-08-17 | Dikovskiy Aleksander Vladimirovich | Pharmazeutische zusammensetzung zur prävention und behandlung von knochenresorption unterschiedlicher ätiologie |
KR20110079813A (ko) | 2008-09-22 | 2011-07-08 | 아이시스 이노베이션 리미티드 | 이미다조〔1,2-α〕피리디닐 비스포스포네이트 |
US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
EP3084483A1 (de) * | 2013-12-19 | 2016-10-26 | 3M Innovative Properties Company | Artikel mit selbstorganisierten schichten mit nanopartikeln mit einer phosphoroberflächenbehandlung |
CN106361701B (zh) * | 2016-08-31 | 2019-08-27 | 上海交通大学 | 一种脂质体药物载体及其制备方法和应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3751372A (en) | 1971-06-18 | 1973-08-07 | Hercules Inc | Scale and corrosion control in circulating water using polyphosphates and organophonic acids |
GB1508772A (en) | 1975-04-04 | 1978-04-26 | Shell Int Research | Biologically active compositions |
DD150744A1 (de) | 1980-04-02 | 1981-09-16 | Sigurd Wobst | Verfahren zur kontinuierlichen herstellung von cycloalkylhydroperoxiden |
IT1201087B (it) | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
DE3434667A1 (de) * | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
IT1187828B (it) * | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
JPS63165457A (ja) | 1986-12-27 | 1988-07-08 | Lion Corp | 導電性樹脂組成物 |
JPS63286478A (ja) | 1987-05-19 | 1988-11-24 | Lion Corp | 導電性塗料組成物 |
DD273650A1 (de) | 1988-07-01 | 1989-11-22 | Robotron Elektronik | Verfahren zur chemischen anschlagvernicklung von kupferstrukturen auf dielektrika |
HUT63323A (en) | 1990-07-13 | 1993-08-30 | Procter & Gamble | Composition against dental deposits, comprissing azacycloalkane diphosphonates |
EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
CA2077312C (en) * | 1992-09-01 | 2000-02-08 | Ronald L. Oleka | Condensate polisher regenerant system |
JPH06100576A (ja) * | 1992-09-21 | 1994-04-12 | Kirin Brewery Co Ltd | 骨粗鬆症治療剤または予防剤 |
JP3238304B2 (ja) * | 1995-08-11 | 2001-12-10 | 三菱重工業株式会社 | スケール溶解液 |
JP3445426B2 (ja) | 1995-12-26 | 2003-09-08 | 花王株式会社 | 高吸水性樹脂組成物 |
-
1997
- 1997-07-08 US US09/446,617 patent/US6410782B1/en not_active Expired - Fee Related
- 1997-07-09 IT IT97MI001628A patent/IT1293305B1/it active IP Right Grant
-
1998
- 1998-07-08 KR KR10-2000-7000135A patent/KR100396036B1/ko not_active IP Right Cessation
- 1998-07-08 DE DE69818823T patent/DE69818823T2/de not_active Expired - Fee Related
- 1998-07-08 IL IL13317298A patent/IL133172A/xx not_active IP Right Cessation
- 1998-07-08 JP JP2000502060A patent/JP3681637B2/ja not_active Expired - Fee Related
- 1998-07-08 AT AT98939625T patent/ATE251631T1/de not_active IP Right Cessation
- 1998-07-08 AU AU88067/98A patent/AU8806798A/en not_active Abandoned
- 1998-07-08 CN CNB988069326A patent/CN1161363C/zh not_active Expired - Fee Related
- 1998-07-08 BR BR9810561-2A patent/BR9810561A/pt not_active Application Discontinuation
- 1998-07-08 CA CA002303210A patent/CA2303210A1/en not_active Abandoned
- 1998-07-08 ES ES98939625T patent/ES2207853T3/es not_active Expired - Lifetime
- 1998-07-08 WO PCT/EP1998/004238 patent/WO1999002539A1/en active IP Right Grant
- 1998-07-08 EP EP98939625A patent/EP0994884B1/de not_active Expired - Lifetime
- 1998-07-08 DK DK98939625T patent/DK0994884T3/da active
- 1998-07-08 HU HU0004679A patent/HUP0004679A3/hu unknown
- 1998-07-08 PT PT98939625T patent/PT994884E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
US6410782B1 (en) | 2002-06-25 |
JP3681637B2 (ja) | 2005-08-10 |
HUP0004679A2 (hu) | 2001-08-28 |
KR100396036B1 (ko) | 2003-08-27 |
JP2001509510A (ja) | 2001-07-24 |
ATE251631T1 (de) | 2003-10-15 |
ITMI971628A1 (it) | 1999-01-09 |
EP0994884B1 (de) | 2003-10-08 |
DK0994884T3 (da) | 2004-02-16 |
CN1261892A (zh) | 2000-08-02 |
IL133172A0 (en) | 2001-03-19 |
HUP0004679A3 (en) | 2002-04-29 |
IL133172A (en) | 2005-03-20 |
IT1293305B1 (it) | 1999-02-16 |
PT994884E (pt) | 2004-02-27 |
CA2303210A1 (en) | 1999-01-21 |
ITMI971628A0 (de) | 1997-07-09 |
KR20010021577A (ko) | 2001-03-15 |
ES2207853T3 (es) | 2004-06-01 |
CN1161363C (zh) | 2004-08-11 |
DE69818823T2 (de) | 2004-05-06 |
BR9810561A (pt) | 2000-08-15 |
EP0994884A1 (de) | 2000-04-26 |
WO1999002539A1 (en) | 1999-01-21 |
AU8806798A (en) | 1999-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: EURODRUG LTD., HONG KONG, CN Owner name: LIPOTEC, S.A., L'HOSPITALET DE LLOBREGAT, BARCELON |
|
8339 | Ceased/non-payment of the annual fee |