MX9304787A - Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen. - Google Patents

Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen.

Info

Publication number
MX9304787A
MX9304787A MX9304787A MX9304787A MX9304787A MX 9304787 A MX9304787 A MX 9304787A MX 9304787 A MX9304787 A MX 9304787A MX 9304787 A MX9304787 A MX 9304787A MX 9304787 A MX9304787 A MX 9304787A
Authority
MX
Mexico
Prior art keywords
pharmaceutical compositions
prodroges
imidazolcarboxilic
acids
contain
Prior art date
Application number
MX9304787A
Other languages
English (en)
Inventor
Robert John Ardecky
Carol Lee Ensinger
James Russell Prutt
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX9304787A publication Critical patent/MX9304787A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con prodrogas de ácidosimidazolcarboxílicos los cuales son antagonistas de la AII útiles en eltratamiento de la hipertensión, las composiciones farmacéuticas de losmismos y un método de tratamiento de la hipertensión utilizando talesprodrogas.
MX9304787A 1992-08-06 1993-08-06 Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen. MX9304787A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists

Publications (1)

Publication Number Publication Date
MX9304787A true MX9304787A (es) 1995-01-31

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304787A MX9304787A (es) 1992-08-06 1993-08-06 Prodrogas de acidos de imidazolcarboxilicos y composiciones farmaceuticasque las contienen.

Country Status (18)

Country Link
US (1) US5310929A (es)
EP (1) EP0654027A1 (es)
JP (1) JP2892838B2 (es)
CN (1) CN1090275A (es)
AU (1) AU688735B2 (es)
BR (1) BR9306911A (es)
CA (1) CA2141692C (es)
FI (1) FI950485A (es)
HU (1) HU9500349D0 (es)
IL (1) IL106553A0 (es)
MX (1) MX9304787A (es)
NO (1) NO950404D0 (es)
PL (1) PL307309A1 (es)
SG (1) SG47108A1 (es)
SK (1) SK13195A3 (es)
TW (1) TW239131B (es)
WO (1) WO1994003435A1 (es)
ZA (1) ZA935693B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
RU2109736C1 (ru) * 1992-12-17 1998-04-27 Санкио Компани Лимитед Производные бифенила и способ их получения
RU2123847C1 (ru) * 1994-03-16 1998-12-27 Санкио Компани Лимитед Лекарственное средство и способ лечения повышенного глазного давления и/или глаукомы
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
DE60222409T2 (de) 2001-05-31 2008-09-25 Vicore Pharma Ab Trizyklische verbindungen, nützlich als angiotensin ii agonisten
ATE398121T1 (de) * 2003-01-16 2008-07-15 Teva Pharma Neue synthese von irbesartan
CN101434647A (zh) 2004-01-20 2009-05-20 爱知县 由HLA-A2402-限制的Ep-CAM-特异的CTL识别的表位/肽及其应用
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US20060074117A1 (en) * 2004-09-02 2006-04-06 Lilach Hedvati Purification of olmesartan medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
WO2006115834A1 (en) * 2005-04-20 2006-11-02 Merck & Co., Inc. Angiotensin ii receptor antagonists
ES2302671T1 (es) * 2006-08-29 2008-08-01 Teva Pharmaceutical Industries Ltd. Procedimientos para la sintesis de 5-fenil-1-tritil-1h-tetrazol.
KR101458369B1 (ko) * 2006-10-09 2014-11-05 씨아이피엘에이 엘티디. 트리틸 올메사탄 메독소밀 및 올메사탄 메독소밀의 제조방법
WO2008067687A1 (fr) * 2006-12-06 2008-06-12 Shanghai Allist Pharmaceutical., Inc. Sels de dérivés d'acide imidazol-5-carboxylique, procédés de préparation et utilisation
WO2011084848A2 (en) * 2010-01-07 2011-07-14 Alkermes, Inc. Prodrugs of heteraromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN111018841B (zh) * 2013-11-01 2023-04-07 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
JP2022542437A (ja) 2019-08-02 2022-10-03 ランティオペプ ベスローテン ヴェンノーツハップ 癌の処置に用いるアンジオテンシン２型（ａｔ２）受容体アゴニスト

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
WO1991000277A1 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
SG50669A1 (en) * 1989-06-30 1998-07-20 Du Pont Fused-ring aryl subtituted imidazoles
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
PT573218E (pt) * 1992-06-02 2001-06-29 Sankyo Co 4-carbonilimidazoles como antagonistas de angiotensina ii e sua utilizacao terapeutica

Also Published As

Publication number Publication date
CA2141692A1 (en) 1994-02-17
JP2892838B2 (ja) 1999-05-17
FI950485A0 (fi) 1995-02-03
WO1994003435A1 (en) 1994-02-17
HU9500349D0 (en) 1995-03-28
BR9306911A (pt) 1998-12-08
SG47108A1 (en) 1998-03-20
CN1090275A (zh) 1994-08-03
AU4790393A (en) 1994-03-03
AU688735B2 (en) 1998-03-19
EP0654027A1 (en) 1995-05-24
CA2141692C (en) 2006-05-30
NO950404D0 (no) 1995-02-03
TW239131B (es) 1995-01-21
JPH08500103A (ja) 1996-01-09
SK13195A3 (en) 1995-07-11
IL106553A0 (en) 1993-12-08
ZA935693B (en) 1995-02-06
US5310929A (en) 1994-05-10
FI950485A (fi) 1995-02-03
PL307309A1 (en) 1995-05-15

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