FI950485A0 - Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina - Google Patents
Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteinaInfo
- Publication number
- FI950485A0 FI950485A0 FI950485A FI950485A FI950485A0 FI 950485 A0 FI950485 A0 FI 950485A0 FI 950485 A FI950485 A FI 950485A FI 950485 A FI950485 A FI 950485A FI 950485 A0 FI950485 A0 FI 950485A0
- Authority
- FI
- Finland
- Prior art keywords
- angiotensin
- receptor antagonists
- prodrug forms
- imidazolecarboxylic
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/926,795 US5310929A (en) | 1992-08-06 | 1992-08-06 | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
PCT/US1993/007103 WO1994003435A1 (en) | 1992-08-06 | 1993-08-02 | Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
FI950485A0 true FI950485A0 (fi) | 1995-02-03 |
FI950485A FI950485A (fi) | 1995-02-03 |
Family
ID=25453732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI950485A FI950485A (fi) | 1992-08-06 | 1995-02-03 | Imidatsolikarboksyylihappojen prodrugmuotoja angiotensiini II-reseptorin antagonisteina |
Country Status (18)
Country | Link |
---|---|
US (1) | US5310929A (fi) |
EP (1) | EP0654027A1 (fi) |
JP (1) | JP2892838B2 (fi) |
CN (1) | CN1090275A (fi) |
AU (1) | AU688735B2 (fi) |
BR (1) | BR9306911A (fi) |
CA (1) | CA2141692C (fi) |
FI (1) | FI950485A (fi) |
HU (1) | HU9500349D0 (fi) |
IL (1) | IL106553A0 (fi) |
MX (1) | MX9304787A (fi) |
NO (1) | NO950404D0 (fi) |
PL (1) | PL307309A1 (fi) |
SG (1) | SG47108A1 (fi) |
SK (1) | SK13195A3 (fi) |
TW (1) | TW239131B (fi) |
WO (1) | WO1994003435A1 (fi) |
ZA (1) | ZA935693B (fi) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
TW259786B (fi) * | 1992-12-17 | 1995-10-11 | Sankyo Co | |
WO1995024902A1 (fr) * | 1994-03-16 | 1995-09-21 | Sankyo Company, Limited | Reducteur de tension oculaire |
US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
US5510495A (en) * | 1994-09-19 | 1996-04-23 | The Du Pont Merck Pharmaceutical Company | Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis |
ES2129850T3 (es) * | 1994-09-20 | 1999-06-16 | Wakunaga Seiyaku Kk | Procedimiento de produccion de un derivado de n-bifenilmetiltiadiazolina o una sal de este y su producto intermediario de produccion. |
IT1292437B1 (it) * | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
IT1295405B1 (it) * | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
ES2154191B1 (es) * | 1998-11-24 | 2001-10-16 | Ferrer Int | Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. |
GR20000100281A (el) * | 2000-08-17 | 2002-05-24 | Ιωαννης Ματσουκας | Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων |
DK1395566T3 (da) | 2001-05-31 | 2008-01-07 | Vicore Pharma Ab | Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister |
EP2189457A1 (en) * | 2003-01-16 | 2010-05-26 | Teva Pharmaceutical Industries Ltd. | Novel synthesis of irbesartan |
JP4779067B2 (ja) | 2004-01-20 | 2011-09-21 | 愛知県 | HLA−A2402拘束性Ep−CAM特異的CTLが認識するエピトープ・ペプチド及びその用途 |
US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
CA2575177A1 (en) * | 2004-09-02 | 2006-03-16 | Teva Pharmaceutical Industries Ltd. | Purification of olmesartan medoxomil |
US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
US20090123538A1 (en) * | 2005-04-20 | 2009-05-14 | Alani Laman L | Angiotensin II Receptor Antagonists |
WO2008027385A2 (en) * | 2006-08-29 | 2008-03-06 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole |
EP2074116A2 (en) * | 2006-10-09 | 2009-07-01 | Cipla Limited | Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil |
AU2006351517B8 (en) * | 2006-12-06 | 2012-01-19 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof |
EP2521545B1 (en) * | 2010-01-07 | 2019-11-27 | Alkermes Pharma Ireland Limited | Prodrugs of heteroaromatic compounds |
EP2455388A1 (en) | 2010-11-23 | 2012-05-23 | LanthioPep B.V. | Novel angiotensin type 2 (AT2) receptor agonists and uses thereof. |
CN104610232B (zh) * | 2013-11-01 | 2019-09-20 | 深圳信立泰药业股份有限公司 | 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物 |
EP4007592A1 (en) | 2019-08-02 | 2022-06-08 | LanthioPep B.V. | Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
HU217958B (hu) * | 1989-06-30 | 2000-05-28 | E. I. Du Pont De Nemours And Co. | Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
JP2568315B2 (ja) * | 1989-06-30 | 1997-01-08 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 縮合環アリール置換イミダゾール |
GB8927277D0 (en) * | 1989-12-01 | 1990-01-31 | Glaxo Group Ltd | Chemical compounds |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
ATE199548T1 (de) * | 1992-06-02 | 2001-03-15 | Sankyo Co | 4-carboxyimidazolderivate als angiotensin-ii- antagonisten und ihre therapeutische verwendung |
-
1992
- 1992-08-06 US US07/926,795 patent/US5310929A/en not_active Expired - Lifetime
-
1993
- 1993-08-02 JP JP6505415A patent/JP2892838B2/ja not_active Expired - Lifetime
- 1993-08-02 HU HU9500349A patent/HU9500349D0/hu unknown
- 1993-08-02 IL IL106553A patent/IL106553A0/xx unknown
- 1993-08-02 AU AU47903/93A patent/AU688735B2/en not_active Ceased
- 1993-08-02 EP EP93918463A patent/EP0654027A1/en not_active Withdrawn
- 1993-08-02 SK SK131-95A patent/SK13195A3/sk unknown
- 1993-08-02 PL PL93307309A patent/PL307309A1/xx unknown
- 1993-08-02 SG SG1996008109A patent/SG47108A1/en unknown
- 1993-08-02 WO PCT/US1993/007103 patent/WO1994003435A1/en not_active Application Discontinuation
- 1993-08-02 CA CA002141692A patent/CA2141692C/en not_active Expired - Lifetime
- 1993-08-02 BR BR9306911A patent/BR9306911A/pt not_active Application Discontinuation
- 1993-08-05 ZA ZA935693A patent/ZA935693B/xx unknown
- 1993-08-06 MX MX9304787A patent/MX9304787A/es unknown
- 1993-08-06 CN CN93117634A patent/CN1090275A/zh active Pending
- 1993-08-06 TW TW082106302A patent/TW239131B/zh active
-
1995
- 1995-02-03 FI FI950485A patent/FI950485A/fi not_active Application Discontinuation
- 1995-02-03 NO NO950404A patent/NO950404D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2141692C (en) | 2006-05-30 |
TW239131B (fi) | 1995-01-21 |
SG47108A1 (en) | 1998-03-20 |
HU9500349D0 (en) | 1995-03-28 |
EP0654027A1 (en) | 1995-05-24 |
MX9304787A (es) | 1995-01-31 |
CA2141692A1 (en) | 1994-02-17 |
NO950404D0 (no) | 1995-02-03 |
WO1994003435A1 (en) | 1994-02-17 |
SK13195A3 (en) | 1995-07-11 |
JPH08500103A (ja) | 1996-01-09 |
US5310929A (en) | 1994-05-10 |
CN1090275A (zh) | 1994-08-03 |
AU4790393A (en) | 1994-03-03 |
PL307309A1 (en) | 1995-05-15 |
IL106553A0 (en) | 1993-12-08 |
FI950485A (fi) | 1995-02-03 |
JP2892838B2 (ja) | 1999-05-17 |
ZA935693B (en) | 1995-02-06 |
BR9306911A (pt) | 1998-12-08 |
AU688735B2 (en) | 1998-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |