DK0569013T3 - Quinolinforbindelser som angiotensin II antagonister - Google Patents
Quinolinforbindelser som angiotensin II antagonisterInfo
- Publication number
- DK0569013T3 DK0569013T3 DK93107366.2T DK93107366T DK0569013T3 DK 0569013 T3 DK0569013 T3 DK 0569013T3 DK 93107366 T DK93107366 T DK 93107366T DK 0569013 T3 DK0569013 T3 DK 0569013T3
- Authority
- DK
- Denmark
- Prior art keywords
- angiotensin
- antagonists
- quinoline compounds
- quinoline
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14340792 | 1992-05-08 | ||
| JP17618892 | 1992-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0569013T3 true DK0569013T3 (da) | 1996-09-16 |
Family
ID=26475148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95116041T DK0693478T3 (da) | 1992-05-08 | 1993-05-06 | Quinolinforbindelser |
| DK93107366.2T DK0569013T3 (da) | 1992-05-08 | 1993-05-06 | Quinolinforbindelser som angiotensin II antagonister |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95116041T DK0693478T3 (da) | 1992-05-08 | 1993-05-06 | Quinolinforbindelser |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5478832A (da) |
| EP (2) | EP0693478B1 (da) |
| KR (1) | KR100227437B1 (da) |
| CA (1) | CA2095680A1 (da) |
| DE (2) | DE69320371T2 (da) |
| DK (2) | DK0693478T3 (da) |
| ES (2) | ES2092172T3 (da) |
| TW (1) | TW369533B (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| FR2699174B1 (fr) * | 1992-12-14 | 1995-01-20 | Synthelabo | Dérivés de 3-(quinoléin-6-yl-méthyl)-4H-imidazol-4-one, leur préparation et leur application en thérapeutique. |
| FR2710914B1 (fr) * | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de 2-[2-(tétrazol-5-yl)phényl]-1,2-dihydroquinoléine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
| FR2716196B1 (fr) * | 1994-02-16 | 1996-04-05 | Synthelabo | Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique. |
| ES2136782T3 (es) * | 1994-10-27 | 1999-12-01 | Asahi Glass Co Ltd | Procedimiento para producir compuestos de acido quinolin-2-il-benzoico. |
| JPH0959277A (ja) * | 1995-08-17 | 1997-03-04 | Green Cross Corp:The | ６−アミノメチル置換キノリン安息香酸類の製造方法 |
| JPH09202774A (ja) * | 1996-01-25 | 1997-08-05 | Green Cross Corp:The | ２−アリールキノリン類およびその製造方法 |
| JPH101471A (ja) * | 1996-06-13 | 1998-01-06 | Green Cross Corp:The | Ｎ−［（キノリン−２−イル）フェニル］スルホンアミド類の結晶およびその製造方法 |
| CN1235546A (zh) * | 1996-08-30 | 1999-11-17 | 吉富制药株式会社 | 肌肉组织变性的预防或治疗剂 |
| GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7208502B2 (en) * | 2002-01-18 | 2007-04-24 | Maniv Energy Capital | Methods of treating conditions associated with an Edg-3 receptor |
| EP1541149A1 (en) * | 2002-06-26 | 2005-06-15 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| US20040167181A1 (en) * | 2003-01-16 | 2004-08-26 | David Solow-Cordero | Methods of treating conditions associated with an Edg-3 receptor |
| JP2007525165A (ja) | 2003-03-07 | 2007-09-06 | トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | タイプ１ライアノジン受容体に基づく方法 |
| US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| MX2011004088A (es) * | 2008-10-15 | 2011-09-06 | Kissei Pharmaceutical | Derivado de anillo fusionado y su aplicacion medica. |
| MY189505A (en) | 2012-10-16 | 2022-02-16 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of roryt |
| KR20150070350A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | Ror-감마-t의 페닐 결합 퀴놀리닐 조절제 |
| ES2619610T3 (es) | 2012-10-16 | 2017-06-26 | Janssen Pharmaceutica Nv | Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo |
| US9346782B2 (en) | 2013-10-15 | 2016-05-24 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| CA2927182A1 (en) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Quinolinyl modulators of ror.gamma.t |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| JP2024500919A (ja) * | 2020-12-23 | 2024-01-10 | ジェンザイム・コーポレーション | 重水素化コロニー刺激因子－１受容体（ｃｓｆ－１ｒ）阻害剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| DE59208448D1 (de) * | 1991-08-15 | 1997-06-12 | Ciba Geigy Ag | N-Acyl-N-Heterocyclyl- oder Naphthylalkyl-Aminosäuren als Angiotensin II Antagonisten |
| US5371227A (en) * | 1991-10-28 | 1994-12-06 | Synthelabo | Quinoline derivatives, process for their preparation, and their therapeutic applications |
| FR2683819B1 (fr) * | 1991-10-28 | 1994-02-11 | Synthelabo | Derives de quinoleine, leur procede de preparation et leur application en therapeutique. |
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
-
1993
- 1993-05-04 US US08/055,873 patent/US5478832A/en not_active Expired - Fee Related
- 1993-05-06 ES ES93107366T patent/ES2092172T3/es not_active Expired - Lifetime
- 1993-05-06 DE DE69320371T patent/DE69320371T2/de not_active Expired - Fee Related
- 1993-05-06 EP EP95116041A patent/EP0693478B1/en not_active Expired - Lifetime
- 1993-05-06 DK DK95116041T patent/DK0693478T3/da active
- 1993-05-06 ES ES95116041T patent/ES2121273T3/es not_active Expired - Lifetime
- 1993-05-06 EP EP93107366A patent/EP0569013B1/en not_active Expired - Lifetime
- 1993-05-06 DK DK93107366.2T patent/DK0569013T3/da active
- 1993-05-06 CA CA002095680A patent/CA2095680A1/en not_active Abandoned
- 1993-05-06 DE DE69304243T patent/DE69304243T2/de not_active Expired - Fee Related
- 1993-05-08 KR KR1019930007901A patent/KR100227437B1/ko not_active IP Right Cessation
- 1993-05-19 TW TW082103956A patent/TW369533B/zh active
-
1995
- 1995-10-10 US US08/541,965 patent/US5665881A/en not_active Expired - Fee Related
- 1995-10-27 US US08/549,142 patent/US5780634A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW369533B (en) | 1999-09-11 |
| EP0693478A1 (en) | 1996-01-24 |
| US5780634A (en) | 1998-07-14 |
| KR100227437B1 (ko) | 1999-11-01 |
| US5665881A (en) | 1997-09-09 |
| DE69304243D1 (de) | 1996-10-02 |
| EP0693478B1 (en) | 1998-08-12 |
| EP0569013A1 (en) | 1993-11-10 |
| ES2121273T3 (es) | 1998-11-16 |
| CA2095680A1 (en) | 1993-11-09 |
| US5478832A (en) | 1995-12-26 |
| DE69320371T2 (de) | 1999-01-28 |
| EP0569013B1 (en) | 1996-08-28 |
| ES2092172T3 (es) | 1996-11-16 |
| DK0693478T3 (da) | 1999-05-10 |
| DE69320371D1 (de) | 1998-09-17 |
| KR940005566A (ko) | 1994-03-21 |
| DE69304243T2 (de) | 1997-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0569013T3 (da) | Quinolinforbindelser som angiotensin II antagonister | |
| NO932005D0 (no) | Angiotensin-ii-antagonister | |
| FI943876A (fi) | Heterobisykliset yhdisteet | |
| FI932695A (fi) | Angiotensin i kymas-inhibitorer inklusive humant hjaertkymas | |
| NO965036L (no) | Kinolinderivater som techykinin NK3 reseptor-antagonister | |
| DK0738150T3 (da) | Bicykliske fibrinogene antagonister | |
| DK154192D0 (da) | Heterocycliske forbindelser | |
| KR950700304A (ko) | 5ht4-수용체 길항질로서 축합 인돌 유도체(condensed indole derivatives as 5ht4-receptor antagonists) | |
| ID15999A (id) | Antagonis oksitokin | |
| EP0574787A3 (en) | Benzimidazole derivatives as angiotensin ii antagonists | |
| NO991384D0 (no) | Substituerte heterocykler som anti-tumormidler | |
| DK0922034T3 (da) | Tetrahydroquinolinderivater som EAA-antagonister | |
| ITMI920347A0 (it) | Composizioni poliolefiniche termosaldabili | |
| DE69204920T2 (de) | Angiotensin-II-Antagoniste. | |
| FI951798A0 (fi) | Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina | |
| NO961333D0 (no) | Nye pyrazolderivater som angiotensin-II-antagonister | |
| FI943359A (fi) | Atsasykliset-heterosykliset yhdisteet angiotensiini II reseptoriantagonisteina | |
| NO950684L (no) | Nye imidazopyridinderivater som angiotensin II-antagonister | |
| EP0591891A3 (en) | Benzimidazole derivatives as angiotensin ii antagonists | |
| FI941118A0 (fi) | Bentsyyli-imidatsopyridiinijohdannainen angiotensiini II reseptoriantagonistina | |
| DK0882044T3 (da) | 1,4-dihydropyridinforbindelser som bradykinin-antagonister | |
| AU5376194A (en) | Heterocyclic compounds as angiotensin ii antagonists | |
| FI941117A (fi) | Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina | |
| KR970702876A (ko) | 뉴로키닌 길항제(Neurokinine (tachykinine) antagonists) | |
| FI970143A (fi) | Kinoliinijohdannaiset leukotrieeniantagonisteina |