DK0693478T3 - Quinolinforbindelser - Google Patents
QuinolinforbindelserInfo
- Publication number
- DK0693478T3 DK0693478T3 DK95116041T DK95116041T DK0693478T3 DK 0693478 T3 DK0693478 T3 DK 0693478T3 DK 95116041 T DK95116041 T DK 95116041T DK 95116041 T DK95116041 T DK 95116041T DK 0693478 T3 DK0693478 T3 DK 0693478T3
- Authority
- DK
- Denmark
- Prior art keywords
- quinoline compounds
- quinoline
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14340792 | 1992-05-08 | ||
| JP17618892 | 1992-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0693478T3 true DK0693478T3 (da) | 1999-05-10 |
Family
ID=26475148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95116041T DK0693478T3 (da) | 1992-05-08 | 1993-05-06 | Quinolinforbindelser |
| DK93107366.2T DK0569013T3 (da) | 1992-05-08 | 1993-05-06 | Quinolinforbindelser som angiotensin II antagonister |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93107366.2T DK0569013T3 (da) | 1992-05-08 | 1993-05-06 | Quinolinforbindelser som angiotensin II antagonister |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5478832A (da) |
| EP (2) | EP0569013B1 (da) |
| KR (1) | KR100227437B1 (da) |
| CA (1) | CA2095680A1 (da) |
| DE (2) | DE69304243T2 (da) |
| DK (2) | DK0693478T3 (da) |
| ES (2) | ES2092172T3 (da) |
| TW (1) | TW369533B (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| FR2699174B1 (fr) * | 1992-12-14 | 1995-01-20 | Synthelabo | Dérivés de 3-(quinoléin-6-yl-méthyl)-4H-imidazol-4-one, leur préparation et leur application en thérapeutique. |
| FR2710914B1 (fr) * | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de 2-[2-(tétrazol-5-yl)phényl]-1,2-dihydroquinoléine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
| FR2716196B1 (fr) * | 1994-02-16 | 1996-04-05 | Synthelabo | Dérivés de 8-[2-(1H-tétrazol-5-yl) phényl] quinoléine, leur préparation et leur application en thérapeutique. |
| EP0709377B1 (en) * | 1994-10-27 | 1999-09-29 | Asahi Glass Company Ltd. | Process for producing quinolin-2-yl benzoic acid compounds |
| JPH0959277A (ja) * | 1995-08-17 | 1997-03-04 | Green Cross Corp:The | ６−アミノメチル置換キノリン安息香酸類の製造方法 |
| JPH09202774A (ja) * | 1996-01-25 | 1997-08-05 | Green Cross Corp:The | ２−アリールキノリン類およびその製造方法 |
| JPH101471A (ja) * | 1996-06-13 | 1998-01-06 | Green Cross Corp:The | Ｎ−［（キノリン−２−イル）フェニル］スルホンアミド類の結晶およびその製造方法 |
| US6060480A (en) * | 1996-08-30 | 2000-05-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Preventives/remedies for muscle tissue degenerations |
| GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7208502B2 (en) * | 2002-01-18 | 2007-04-24 | Maniv Energy Capital | Methods of treating conditions associated with an Edg-3 receptor |
| EP1541149A1 (en) * | 2002-06-26 | 2005-06-15 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| US20040167181A1 (en) * | 2003-01-16 | 2004-08-26 | David Solow-Cordero | Methods of treating conditions associated with an Edg-3 receptor |
| AU2004220548A1 (en) | 2003-03-07 | 2004-09-23 | The Trustees Of Columbia University, In The City Of New York | Type 1 ryanodine receptor-based methods |
| US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| EP2343279B1 (en) * | 2008-10-15 | 2018-02-28 | Kissei Pharmaceutical Co., Ltd. | Fused-ring derivative and medical application of same |
| CA2888210C (en) | 2012-10-16 | 2021-02-09 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| WO2014062655A1 (en) | 2012-10-16 | 2014-04-24 | Janssen Pharmaceutica Nv | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt |
| AU2013331505A1 (en) | 2012-10-16 | 2015-04-30 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ROR-gamma-t |
| JP6423423B2 (ja) | 2013-10-15 | 2018-11-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｒｏｒγｔのアルキル結合キノリニルモジュレーター |
| EP3057422B1 (en) | 2013-10-15 | 2019-05-15 | Janssen Pharmaceutica NV | Quinolinyl modulators of ror(gamma)t |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| JP2024500919A (ja) * | 2020-12-23 | 2024-01-10 | ジェンザイム・コーポレーション | 重水素化コロニー刺激因子－１受容体（ｃｓｆ－１ｒ）阻害剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| DK0528762T3 (da) * | 1991-08-15 | 1997-08-25 | Ciba Geigy Ag | N-acyl-N-heterocyclyl- eller naphthylalkyl-aminosyrer som angiotensin II antagonister |
| FR2683819B1 (fr) * | 1991-10-28 | 1994-02-11 | Synthelabo | Derives de quinoleine, leur procede de preparation et leur application en therapeutique. |
| US5371227A (en) * | 1991-10-28 | 1994-12-06 | Synthelabo | Quinoline derivatives, process for their preparation, and their therapeutic applications |
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
-
1993
- 1993-05-04 US US08/055,873 patent/US5478832A/en not_active Expired - Fee Related
- 1993-05-06 DE DE69304243T patent/DE69304243T2/de not_active Expired - Fee Related
- 1993-05-06 ES ES93107366T patent/ES2092172T3/es not_active Expired - Lifetime
- 1993-05-06 CA CA002095680A patent/CA2095680A1/en not_active Abandoned
- 1993-05-06 EP EP93107366A patent/EP0569013B1/en not_active Expired - Lifetime
- 1993-05-06 ES ES95116041T patent/ES2121273T3/es not_active Expired - Lifetime
- 1993-05-06 DK DK95116041T patent/DK0693478T3/da active
- 1993-05-06 DE DE69320371T patent/DE69320371T2/de not_active Expired - Fee Related
- 1993-05-06 DK DK93107366.2T patent/DK0569013T3/da active
- 1993-05-06 EP EP95116041A patent/EP0693478B1/en not_active Expired - Lifetime
- 1993-05-08 KR KR1019930007901A patent/KR100227437B1/ko not_active IP Right Cessation
- 1993-05-19 TW TW082103956A patent/TW369533B/zh active
-
1995
- 1995-10-10 US US08/541,965 patent/US5665881A/en not_active Expired - Fee Related
- 1995-10-27 US US08/549,142 patent/US5780634A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0569013A1 (en) | 1993-11-10 |
| TW369533B (en) | 1999-09-11 |
| EP0569013B1 (en) | 1996-08-28 |
| KR100227437B1 (ko) | 1999-11-01 |
| DE69320371D1 (de) | 1998-09-17 |
| US5780634A (en) | 1998-07-14 |
| DE69304243T2 (de) | 1997-03-06 |
| ES2092172T3 (es) | 1996-11-16 |
| US5665881A (en) | 1997-09-09 |
| KR940005566A (ko) | 1994-03-21 |
| EP0693478B1 (en) | 1998-08-12 |
| DE69304243D1 (de) | 1996-10-02 |
| DE69320371T2 (de) | 1999-01-28 |
| US5478832A (en) | 1995-12-26 |
| ES2121273T3 (es) | 1998-11-16 |
| CA2095680A1 (en) | 1993-11-09 |
| DK0569013T3 (da) | 1996-09-16 |
| EP0693478A1 (en) | 1996-01-24 |
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