DK1395566T3 - Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister - Google Patents

Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister

Info

Publication number
DK1395566T3
DK1395566T3 DK02727773T DK02727773T DK1395566T3 DK 1395566 T3 DK1395566 T3 DK 1395566T3 DK 02727773 T DK02727773 T DK 02727773T DK 02727773 T DK02727773 T DK 02727773T DK 1395566 T3 DK1395566 T3 DK 1395566T3
Authority
DK
Denmark
Prior art keywords
agonists
angiotensin
compounds useful
tricyclic compounds
compounds
Prior art date
Application number
DK02727773T
Other languages
English (en)
Inventor
Anders Hallberg
Mathias Alterman
Original Assignee
Vicore Pharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0113129A external-priority patent/GB0113129D0/en
Priority claimed from GB0121611A external-priority patent/GB0121611D0/en
Priority claimed from GB0201794A external-priority patent/GB0201794D0/en
Application filed by Vicore Pharma Ab filed Critical Vicore Pharma Ab
Application granted granted Critical
Publication of DK1395566T3 publication Critical patent/DK1395566T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
DK02727773T 2001-05-31 2002-05-30 Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister DK1395566T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0113129A GB0113129D0 (en) 2001-05-31 2001-05-31 Pharmaceutically-useful compounds
GB0121611A GB0121611D0 (en) 2001-09-07 2001-09-07 Pharmaceutically-useful-compounds
US35095902P 2002-01-25 2002-01-25
GB0201794A GB0201794D0 (en) 2002-01-26 2002-01-26 Pharmaceutically-useful compounds
PCT/GB2002/002563 WO2002096883A1 (en) 2001-05-31 2002-05-30 Tricyclic compounds useful as angiotensin ii agonists

Publications (1)

Publication Number Publication Date
DK1395566T3 true DK1395566T3 (da) 2008-01-07

Family

ID=27447951

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02727773T DK1395566T3 (da) 2001-05-31 2002-05-30 Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister

Country Status (11)

Country Link
US (2) US7652054B2 (da)
EP (1) EP1395566B1 (da)
CN (1) CN1529697B (da)
AT (1) ATE372987T1 (da)
AU (1) AU2002257970B2 (da)
CA (1) CA2449150C (da)
DE (1) DE60222409T2 (da)
DK (1) DK1395566T3 (da)
ES (1) ES2295339T3 (da)
MX (1) MXPA03011693A (da)
WO (1) WO2002096883A1 (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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WO2004085420A1 (en) * 2003-03-24 2004-10-07 Vicore Pharma Ab Bicyclic compounds useful as angiotensin ii agonists
WO2006099244A1 (en) * 2005-03-11 2006-09-21 Hong Kong Nitric Oxide Limited Combination therapy for endothelial dysfunction, angina and diabetes
EP1869009B1 (en) 2005-04-12 2016-06-01 Vicore Pharma AB New bicyclic angiotensin ii agonists
WO2006109056A1 (en) 2005-04-12 2006-10-19 Vicore Pharma Ab New tricyclic angiotensin ii agonists
AU2006235698B2 (en) 2005-04-12 2012-03-29 Vicore Pharma Ab New tricyclic angiotensin II agonists
PL2172450T3 (pl) * 2007-06-20 2014-03-31 Mitsubishi Tanabe Pharma Corp Nowe pochodne sulfonamidowe kwasu malonowego i ich zastosowanie farmaceutyczne
EP2319525A1 (en) 2009-11-05 2011-05-11 Universitätsklinikum Hamburg-Eppendorf Composition for treating insulin resistance
US8835471B2 (en) 2010-06-11 2014-09-16 Vicore Pharma Ab Use of angiotensin II agonists
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN102816126A (zh) * 2011-06-07 2012-12-12 中国药科大学 具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途
EP2832357A1 (en) * 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selective AT2 receptor agonists for use in treatment of cachexia
WO2015152393A1 (ja) 2014-04-03 2015-10-08 国立研究開発法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
AU2015328174B2 (en) 2014-10-06 2020-05-21 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
US20180078529A1 (en) 2015-03-02 2018-03-22 Vicore Pharma Ab Angiotensin ii receptor agonist for treating pulmonary fibrosis
WO2017173274A1 (en) 2016-03-31 2017-10-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2017205610A1 (en) * 2016-05-25 2017-11-30 University Of Florida Research Foundation, Inc. Use of angiotensin ii receptor agonists in the treatment and prevention of stroke
WO2017221012A1 (en) 2016-06-21 2017-12-28 Vicore Pharma Ab Methods and compositions for preventing or reducing the risk of cancer treatment-related cardiotoxicity
CA3029630A1 (en) 2016-06-29 2018-01-04 Universite De Montreal Biarylmethyl heterocycles
KR102531491B1 (ko) 2016-09-30 2023-05-10 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막횡단 전도 조절자의 조절제, 제약 조성물, 치료 방법, 및 상기 조절제의 제조 방법
JOP20190125B1 (ar) 2016-12-09 2022-03-14 Vertex Pharma مُعدِّل‏ لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل
AU2018279646B2 (en) 2017-06-08 2023-04-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
GB201710906D0 (en) * 2017-07-06 2017-08-23 Vicore Pharma Ab Compounds and methods for treating peripheral neuropathy
BR112020000941A2 (pt) 2017-07-17 2020-07-21 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
AU2018309043B2 (en) 2017-08-02 2022-03-31 Vertex Pharmaceuticals Incorporated Processes for preparing pyrrolidine compounds
AU2018351533B2 (en) 2017-10-19 2023-02-02 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of CFTR modulators
JP7245834B2 (ja) 2017-12-08 2023-03-24 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを作成するためのプロセス
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
WO2019183513A1 (en) * 2018-03-22 2019-09-26 University Of Iowa Research Foundation Compositions and methods for the treatment and prevention of muscular dystrophy
US11414439B2 (en) 2018-04-13 2022-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
WO2019238962A1 (en) 2018-06-14 2019-12-19 University College Cork - National University Of Ireland, Cork Peptide for disease treatment
US20220257698A1 (en) 2019-08-02 2022-08-18 Lanthiopep B.V. Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer
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DE60222409D1 (de) 2007-10-25
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EP1395566A1 (en) 2004-03-10
ATE372987T1 (de) 2007-09-15
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