DK1395566T3 - Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister - Google Patents
Tricycliske forbindelser, der er nyttige som angiotensin Il-agonisterInfo
- Publication number
- DK1395566T3 DK1395566T3 DK02727773T DK02727773T DK1395566T3 DK 1395566 T3 DK1395566 T3 DK 1395566T3 DK 02727773 T DK02727773 T DK 02727773T DK 02727773 T DK02727773 T DK 02727773T DK 1395566 T3 DK1395566 T3 DK 1395566T3
- Authority
- DK
- Denmark
- Prior art keywords
- agonists
- angiotensin
- compounds useful
- tricyclic compounds
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0113129A GB0113129D0 (en) | 2001-05-31 | 2001-05-31 | Pharmaceutically-useful compounds |
GB0121611A GB0121611D0 (en) | 2001-09-07 | 2001-09-07 | Pharmaceutically-useful-compounds |
US35095902P | 2002-01-25 | 2002-01-25 | |
GB0201794A GB0201794D0 (en) | 2002-01-26 | 2002-01-26 | Pharmaceutically-useful compounds |
PCT/GB2002/002563 WO2002096883A1 (en) | 2001-05-31 | 2002-05-30 | Tricyclic compounds useful as angiotensin ii agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1395566T3 true DK1395566T3 (da) | 2008-01-07 |
Family
ID=27447951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02727773T DK1395566T3 (da) | 2001-05-31 | 2002-05-30 | Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister |
Country Status (11)
Country | Link |
---|---|
US (2) | US7652054B2 (da) |
EP (1) | EP1395566B1 (da) |
CN (1) | CN1529697B (da) |
AT (1) | ATE372987T1 (da) |
AU (1) | AU2002257970B2 (da) |
CA (1) | CA2449150C (da) |
DE (1) | DE60222409T2 (da) |
DK (1) | DK1395566T3 (da) |
ES (1) | ES2295339T3 (da) |
MX (1) | MXPA03011693A (da) |
WO (1) | WO2002096883A1 (da) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004085420A1 (en) * | 2003-03-24 | 2004-10-07 | Vicore Pharma Ab | Bicyclic compounds useful as angiotensin ii agonists |
WO2006099244A1 (en) * | 2005-03-11 | 2006-09-21 | Hong Kong Nitric Oxide Limited | Combination therapy for endothelial dysfunction, angina and diabetes |
EP1869009B1 (en) | 2005-04-12 | 2016-06-01 | Vicore Pharma AB | New bicyclic angiotensin ii agonists |
WO2006109056A1 (en) | 2005-04-12 | 2006-10-19 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
AU2006235698B2 (en) | 2005-04-12 | 2012-03-29 | Vicore Pharma Ab | New tricyclic angiotensin II agonists |
PL2172450T3 (pl) * | 2007-06-20 | 2014-03-31 | Mitsubishi Tanabe Pharma Corp | Nowe pochodne sulfonamidowe kwasu malonowego i ich zastosowanie farmaceutyczne |
EP2319525A1 (en) | 2009-11-05 | 2011-05-11 | Universitätsklinikum Hamburg-Eppendorf | Composition for treating insulin resistance |
US8835471B2 (en) | 2010-06-11 | 2014-09-16 | Vicore Pharma Ab | Use of angiotensin II agonists |
EP2455388A1 (en) | 2010-11-23 | 2012-05-23 | LanthioPep B.V. | Novel angiotensin type 2 (AT2) receptor agonists and uses thereof. |
CN102816126A (zh) * | 2011-06-07 | 2012-12-12 | 中国药科大学 | 具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途 |
EP2832357A1 (en) * | 2013-07-29 | 2015-02-04 | Charité - Universitätsmedizin Berlin | Selective AT2 receptor agonists for use in treatment of cachexia |
WO2015152393A1 (ja) | 2014-04-03 | 2015-10-08 | 国立研究開発法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
AU2015328174B2 (en) | 2014-10-06 | 2020-05-21 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
US20180078529A1 (en) | 2015-03-02 | 2018-03-22 | Vicore Pharma Ab | Angiotensin ii receptor agonist for treating pulmonary fibrosis |
WO2017173274A1 (en) | 2016-03-31 | 2017-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
WO2017205610A1 (en) * | 2016-05-25 | 2017-11-30 | University Of Florida Research Foundation, Inc. | Use of angiotensin ii receptor agonists in the treatment and prevention of stroke |
WO2017221012A1 (en) | 2016-06-21 | 2017-12-28 | Vicore Pharma Ab | Methods and compositions for preventing or reducing the risk of cancer treatment-related cardiotoxicity |
CA3029630A1 (en) | 2016-06-29 | 2018-01-04 | Universite De Montreal | Biarylmethyl heterocycles |
KR102531491B1 (ko) | 2016-09-30 | 2023-05-10 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조절제, 제약 조성물, 치료 방법, 및 상기 조절제의 제조 방법 |
JOP20190125B1 (ar) | 2016-12-09 | 2022-03-14 | Vertex Pharma | مُعدِّل لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل |
AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
GB201710906D0 (en) * | 2017-07-06 | 2017-08-23 | Vicore Pharma Ab | Compounds and methods for treating peripheral neuropathy |
BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
AU2018309043B2 (en) | 2017-08-02 | 2022-03-31 | Vertex Pharmaceuticals Incorporated | Processes for preparing pyrrolidine compounds |
AU2018351533B2 (en) | 2017-10-19 | 2023-02-02 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
JP7245834B2 (ja) | 2017-12-08 | 2023-03-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを作成するためのプロセス |
TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
WO2019183513A1 (en) * | 2018-03-22 | 2019-09-26 | University Of Iowa Research Foundation | Compositions and methods for the treatment and prevention of muscular dystrophy |
US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
WO2019238962A1 (en) | 2018-06-14 | 2019-12-19 | University College Cork - National University Of Ireland, Cork | Peptide for disease treatment |
US20220257698A1 (en) | 2019-08-02 | 2022-08-18 | Lanthiopep B.V. | Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer |
GB201913603D0 (en) | 2019-09-20 | 2019-11-06 | Vicore Pharma Ab | New compounds |
GB201917327D0 (en) | 2019-11-28 | 2020-01-15 | Vicore Pharma Ab | New pharmaceutical use |
BR112022018549A2 (pt) | 2020-03-19 | 2022-11-29 | Vicore Pharma Ab | Compostos inovadores úteis no tratamento e/ou prevenção de uma doença, distúrbio ou afecção associada à angiotensina ii |
GB202004094D0 (en) | 2020-03-20 | 2020-05-06 | Vicore Pharma Ab | New compounds and uses |
US11123329B1 (en) | 2020-03-23 | 2021-09-21 | Vicore Pharma Ab | Use of angiotensin II type 2 receptor agonist |
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GB202006074D0 (en) | 2020-04-24 | 2020-06-10 | Vicore Pharma Ab | New composition |
GB202007122D0 (en) | 2020-05-14 | 2020-07-01 | Vicore Pharma Ab | New process |
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GB202104033D0 (en) | 2021-03-23 | 2021-05-05 | Vicore Pharma Ab | New compounds |
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-
2002
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- 2002-05-30 DK DK02727773T patent/DK1395566T3/da active
- 2002-05-30 ES ES02727773T patent/ES2295339T3/es not_active Expired - Lifetime
- 2002-05-30 CA CA2449150A patent/CA2449150C/en not_active Expired - Fee Related
- 2002-05-30 CN CN028143213A patent/CN1529697B/zh not_active Expired - Fee Related
- 2002-05-30 DE DE60222409T patent/DE60222409T2/de not_active Expired - Lifetime
- 2002-05-30 WO PCT/GB2002/002563 patent/WO2002096883A1/en active IP Right Grant
- 2002-05-30 EP EP02727773A patent/EP1395566B1/en not_active Expired - Lifetime
- 2002-05-30 AU AU2002257970A patent/AU2002257970B2/en not_active Ceased
- 2002-05-30 MX MXPA03011693A patent/MXPA03011693A/es active IP Right Grant
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2009
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US20040167176A1 (en) | 2004-08-26 |
CN1529697A (zh) | 2004-09-15 |
US8124638B2 (en) | 2012-02-28 |
MXPA03011693A (es) | 2004-12-06 |
WO2002096883A1 (en) | 2002-12-05 |
US7652054B2 (en) | 2010-01-26 |
CA2449150A1 (en) | 2002-12-05 |
CA2449150C (en) | 2011-07-12 |
DE60222409T2 (de) | 2008-09-25 |
EP1395566B1 (en) | 2007-09-12 |
DE60222409D1 (de) | 2007-10-25 |
ES2295339T3 (es) | 2008-04-16 |
EP1395566A1 (en) | 2004-03-10 |
ATE372987T1 (de) | 2007-09-15 |
US20090326026A1 (en) | 2009-12-31 |
CN1529697B (zh) | 2010-09-22 |
AU2002257970B2 (en) | 2007-08-02 |
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