DE60222409D1 - Trizyklische verbindungen, nützlich als angiotensin ii agonisten - Google Patents

Trizyklische verbindungen, nützlich als angiotensin ii agonisten

Info

Publication number
DE60222409D1
DE60222409D1 DE60222409T DE60222409T DE60222409D1 DE 60222409 D1 DE60222409 D1 DE 60222409D1 DE 60222409 T DE60222409 T DE 60222409T DE 60222409 T DE60222409 T DE 60222409T DE 60222409 D1 DE60222409 D1 DE 60222409D1
Authority
DE
Germany
Prior art keywords
useful
agonists
angiotensin
tricyclic
connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60222409T
Other languages
English (en)
Other versions
DE60222409T2 (de
Inventor
Anders Hallberg
Mathias Alterman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vicore Pharma AB
Original Assignee
Vicore Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0113129A external-priority patent/GB0113129D0/en
Priority claimed from GB0121611A external-priority patent/GB0121611D0/en
Priority claimed from GB0201794A external-priority patent/GB0201794D0/en
Application filed by Vicore Pharma AB filed Critical Vicore Pharma AB
Publication of DE60222409D1 publication Critical patent/DE60222409D1/de
Application granted granted Critical
Publication of DE60222409T2 publication Critical patent/DE60222409T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
DE60222409T 2001-05-31 2002-05-30 Trizyklische verbindungen, nützlich als angiotensin ii agonisten Expired - Lifetime DE60222409T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0113129A GB0113129D0 (en) 2001-05-31 2001-05-31 Pharmaceutically-useful compounds
GB0113129 2001-05-31
GB0121611 2001-09-07
GB0121611A GB0121611D0 (en) 2001-09-07 2001-09-07 Pharmaceutically-useful-compounds
US35095902P 2002-01-25 2002-01-25
US350959P 2002-01-25
GB0201794 2002-01-26
GB0201794A GB0201794D0 (en) 2002-01-26 2002-01-26 Pharmaceutically-useful compounds
PCT/GB2002/002563 WO2002096883A1 (en) 2001-05-31 2002-05-30 Tricyclic compounds useful as angiotensin ii agonists

Publications (2)

Publication Number Publication Date
DE60222409D1 true DE60222409D1 (de) 2007-10-25
DE60222409T2 DE60222409T2 (de) 2008-09-25

Family

ID=27447951

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60222409T Expired - Lifetime DE60222409T2 (de) 2001-05-31 2002-05-30 Trizyklische verbindungen, nützlich als angiotensin ii agonisten

Country Status (11)

Country Link
US (2) US7652054B2 (de)
EP (1) EP1395566B1 (de)
CN (1) CN1529697B (de)
AT (1) ATE372987T1 (de)
AU (1) AU2002257970B2 (de)
CA (1) CA2449150C (de)
DE (1) DE60222409T2 (de)
DK (1) DK1395566T3 (de)
ES (1) ES2295339T3 (de)
MX (1) MXPA03011693A (de)
WO (1) WO2002096883A1 (de)

Families Citing this family (48)

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JP2008533044A (ja) * 2005-03-11 2008-08-21 ホン コン ナイトリック オキサイド リミテッド 内皮機能不全、アンギナおよび糖尿病のための組合せ治療
CA2603254C (en) 2005-04-12 2013-10-29 Vicore Pharma Ab New bicyclic angiotensin ii agonists
EP1869024B1 (de) 2005-04-12 2010-11-10 Vicore Pharma AB Neue tricyclische angiotensin-ii-agonisten
WO2006109048A1 (en) * 2005-04-12 2006-10-19 Vicore Pharma Ab New tricyclic angiotensin ii agonists
PL2172450T3 (pl) * 2007-06-20 2014-03-31 Mitsubishi Tanabe Pharma Corp Nowe pochodne sulfonamidowe kwasu malonowego i ich zastosowanie farmaceutyczne
EP2319525A1 (de) 2009-11-05 2011-05-11 Universitätsklinikum Hamburg-Eppendorf Zusammensetzung zur Behandlung der Insulinresistenz
US8835471B2 (en) 2010-06-11 2014-09-16 Vicore Pharma Ab Use of angiotensin II agonists
EP2455388A1 (de) 2010-11-23 2012-05-23 LanthioPep B.V. Neuartige Rezeptoragonisten von Angiotensin des Typs 2 (AT2) und Verwendungen dafür
CN102816126A (zh) * 2011-06-07 2012-12-12 中国药科大学 具有心血管活性的胺磺酰芳基取代的三氮唑类衍生物、其制备方法及用途
EP2832357A1 (de) 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selektive AT2-Rezeptoragonisten zur Verwendung bei der Behandlung von Kachexie
US10071099B2 (en) 2014-04-03 2018-09-11 National Cerebral And Cardiovascular Center Medicament for suppressing malignant tumor metastasis
TWI735416B (zh) 2014-10-06 2021-08-11 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
KR20170122754A (ko) 2015-03-02 2017-11-06 바이코어 파마 아베 폐섬유증을 치료하기 위한 안지오텐신 ii 수용체 작용제
US10738030B2 (en) 2016-03-31 2020-08-11 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2017205610A1 (en) * 2016-05-25 2017-11-30 University Of Florida Research Foundation, Inc. Use of angiotensin ii receptor agonists in the treatment and prevention of stroke
WO2017221012A1 (en) 2016-06-21 2017-12-28 Vicore Pharma Ab Methods and compositions for preventing or reducing the risk of cancer treatment-related cardiotoxicity
WO2018005591A1 (en) 2016-06-29 2018-01-04 Universite De Montreal Biarylmethyl heterocycles
SG10201913595YA (en) 2016-09-30 2020-02-27 Vertex Pharma Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
WO2018107100A1 (en) 2016-12-09 2018-06-14 Vertex Pharmaceuticals Incorporated Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CA3066084A1 (en) 2017-06-08 2018-12-13 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
GB201710906D0 (en) * 2017-07-06 2017-08-23 Vicore Pharma Ab Compounds and methods for treating peripheral neuropathy
MA49631A (fr) 2017-07-17 2020-05-27 Vertex Pharma Méthodes de traitement de la fibrose kystique
ES2912657T3 (es) 2017-08-02 2022-05-26 Vertex Pharma Procesos para preparar compuestos de pirrolidina
CA3078893A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
WO2019113476A2 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
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US7652054B2 (en) 2010-01-26
EP1395566B1 (de) 2007-09-12
US20090326026A1 (en) 2009-12-31
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