DE602004014107D1 - Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen - Google Patents

Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen

Info

Publication number
DE602004014107D1
DE602004014107D1 DE602004014107T DE602004014107T DE602004014107D1 DE 602004014107 D1 DE602004014107 D1 DE 602004014107D1 DE 602004014107 T DE602004014107 T DE 602004014107T DE 602004014107 T DE602004014107 T DE 602004014107T DE 602004014107 D1 DE602004014107 D1 DE 602004014107D1
Authority
DE
Germany
Prior art keywords
sub
antibiotics
suffering
hydrogen
hydroxymethyl substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004014107T
Other languages
English (en)
Inventor
Michael B Gravestock
Neil J Hales
Daniel R Carcanague
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0304723A external-priority patent/GB0304723D0/en
Priority claimed from GB0318607A external-priority patent/GB0318607D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE602004014107D1 publication Critical patent/DE602004014107D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE602004014107T 2003-03-01 2004-02-24 Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen Expired - Fee Related DE602004014107D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0304723A GB0304723D0 (en) 2003-03-01 2003-03-01 Chemical compounds
GB0318607A GB0318607D0 (en) 2003-08-08 2003-08-08 Chemical compounds
PCT/GB2004/000730 WO2004078753A1 (en) 2003-03-01 2004-02-24 Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents

Publications (1)

Publication Number Publication Date
DE602004014107D1 true DE602004014107D1 (de) 2008-07-10

Family

ID=32964061

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014107T Expired - Fee Related DE602004014107D1 (de) 2003-03-01 2004-02-24 Hydroxymethylsubstituierte dihydroisoxazolderivate, die sich als antibiotika eignen

Country Status (17)

Country Link
US (1) US7192974B2 (de)
EP (1) EP1599471B1 (de)
JP (1) JP2006519247A (de)
KR (1) KR20050106064A (de)
AT (1) ATE396991T1 (de)
AU (1) AU2004218206A1 (de)
BR (1) BRPI0407835A (de)
CA (1) CA2517706A1 (de)
CL (1) CL2004000400A1 (de)
DE (1) DE602004014107D1 (de)
ES (1) ES2305732T3 (de)
HK (1) HK1083097A1 (de)
MX (1) MXPA05009205A (de)
NO (1) NO20054523L (de)
TW (1) TW200500360A (de)
UY (1) UY28211A1 (de)
WO (1) WO2004078753A1 (de)

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IL163688A0 (en) 2002-02-28 2005-12-18 Astrazeneca Ab 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents
KR20040086465A (ko) 2002-02-28 2004-10-08 아스트라제네카 아베 화합물
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
PL1656370T3 (pl) * 2003-06-03 2013-03-29 Melinta Subsidiary Corp Biarylowe związki heterocykliczne oraz sposoby ich wytwarzania i stosowania
AU2004256084B2 (en) * 2003-07-02 2007-10-18 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
RU2348628C2 (ru) * 2003-07-02 2009-03-10 Мерк Энд Ко., Инк. Замещенные циклопропильной группой оксазолидиноновые антибиотики и их производные
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
EP1646630A1 (de) * 2003-07-02 2006-04-19 Merck & Co., Inc. Oxazolidinonantibiotika und derivate davon
EP1660465B1 (de) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Verfahren zur synthese von biaryloxazolidinonen
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
EP1713785A1 (de) 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenierte heterocyclische biarylverbindungen und verfahren zu deren herstellung und verwendung
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US20050241110A1 (en) * 2004-04-09 2005-11-03 Bruce Baker Ergonomic handles, especially for garden tools
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
MXPA06013540A (es) * 2004-05-25 2007-01-26 Astrazeneca Ab Derivados de 3-(4-(2 -dihidroisoxasol -3-ilpiridin-5-il) fenil)-5- triazol-1- ilmetiloxazolidin -2-ona como inhibidores de mao para el tratamiento de infecciones bacterianas.
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
EP1864980A4 (de) 2005-03-30 2010-08-18 Eisai R&D Man Co Ltd Ein pyridinderivat enthaltendes antipilzmittel
WO2006133397A2 (en) * 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP1946840B1 (de) * 2005-11-04 2019-08-21 NGK Insulators, Ltd. Wabenstruktur und wabenkatalysator
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US8183264B2 (en) 2006-09-21 2012-05-22 Eisai R&D Managment Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
US20080190341A1 (en) * 2007-02-08 2008-08-14 Baruh Bradford G System and method of adjusting the location and position of the foresail on a sailboat
US8258394B2 (en) * 2007-02-08 2012-09-04 Bradford G Baruh Retractable solar panel system
US20100065104A1 (en) * 2007-08-31 2010-03-18 Baruh Bradford G Retractable solar panel system
KR100848232B1 (ko) * 2007-04-12 2008-07-24 일동제약주식회사 신규 헤테로 고리 또는 알콕시아미노메틸 옥사졸리디논 및그 제조방법
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
KR20100015897A (ko) * 2007-04-27 2010-02-12 에자이 알앤드디 매니지먼트 가부시키가이샤 헤테로환 치환 피리딘 유도체의 염 또는 그의 결정
WO2008156559A2 (en) * 2007-06-01 2008-12-24 Chx Technologies, Inc. Topical dental solution of chlorhexidine in sumatra benzoin bp/ep and methods of manufacturing and evaluating same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US20110118219A1 (en) * 2008-03-25 2011-05-19 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
WO2009120789A1 (en) 2008-03-26 2009-10-01 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
MX2011003820A (es) * 2008-10-10 2011-06-16 Trius Therapeutics Metodos para preparar oxazolidinonas y composiciones que las contienen.
US8188119B2 (en) * 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
MY156354A (en) 2009-02-03 2016-02-15 Merck Sharp & Dohme Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
ES2552087T3 (es) 2009-02-05 2015-11-25 Tokai Pharmaceuticals, Inc. Nuevos profármacos de inhibidores de CYP17 esteroidales/antiandrógenos
ES2605472T3 (es) * 2009-03-13 2017-03-14 Sun Chemical B.V. Compuesto de carbamato cíclico útil en composiciones curables con energía
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101653570B1 (ko) * 2011-03-30 2016-09-02 주식회사 레고켐 바이오사이언스 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
EP2626356A1 (de) * 2012-02-08 2013-08-14 Rheinische Friedrich-Wilhelms-Universität Bonn Thiamin Analoga und ihre Verwendung als Antibiotika
EP4066841A1 (de) 2013-03-14 2022-10-05 University of Maryland, Baltimore Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon
EP3033088A4 (de) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarker zur behandlung neoplastischer störungen mit androgen-anzielenden therapien
CN112707779B (zh) * 2020-12-26 2023-06-30 蚌埠中实化学技术有限公司 一种乙烯基环己烷的制备方法

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Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
JP2003535860A (ja) * 2000-06-05 2003-12-02 ドン・ア・ファーム・カンパニー・リミテッド 新規なオキサゾリジノン誘導体及びその製造方法
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
CA2459766A1 (en) 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
NZ540147A (en) * 2002-11-28 2008-03-28 Astrazeneca Ab Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
AU2004218206A1 (en) 2004-09-16
HK1083097A1 (en) 2006-06-23
UY28211A1 (es) 2004-09-30
US20060270637A1 (en) 2006-11-30
BRPI0407835A (pt) 2006-02-14
KR20050106064A (ko) 2005-11-08
EP1599471B1 (de) 2008-05-28
JP2006519247A (ja) 2006-08-24
MXPA05009205A (es) 2005-10-18
US7192974B2 (en) 2007-03-20
ES2305732T3 (es) 2008-11-01
CL2004000400A1 (es) 2005-04-22
NO20054523D0 (no) 2005-09-30
TW200500360A (en) 2005-01-01
WO2004078753A1 (en) 2004-09-16
CA2517706A1 (en) 2004-09-16
ATE396991T1 (de) 2008-06-15
EP1599471A1 (de) 2005-11-30
NO20054523L (no) 2005-12-01

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