PT913156E - Utilizacao de proteina c activada para tratar estados hipercoagulaveis associados com sepsia - Google Patents

Utilizacao de proteina c activada para tratar estados hipercoagulaveis associados com sepsia

Info

Publication number
PT913156E
PT913156E PT98308413T PT98308413T PT913156E PT 913156 E PT913156 E PT 913156E PT 98308413 T PT98308413 T PT 98308413T PT 98308413 T PT98308413 T PT 98308413T PT 913156 E PT913156 E PT 913156E
Authority
PT
Portugal
Prior art keywords
protein
activated
sepsia
hyperceragulate
treat
Prior art date
Application number
PT98308413T
Other languages
English (en)
Inventor
Sau-Chi Betty Yan
Grinnell Brian William
Hartman Daniel Lawrence
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT913156E publication Critical patent/PT913156E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
PT98308413T 1997-10-20 1998-10-15 Utilizacao de proteina c activada para tratar estados hipercoagulaveis associados com sepsia PT913156E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6254997P 1997-10-20 1997-10-20
US6476597P 1997-11-07 1997-11-07

Publications (1)

Publication Number Publication Date
PT913156E true PT913156E (pt) 2005-08-31

Family

ID=26742406

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98308413T PT913156E (pt) 1997-10-20 1998-10-15 Utilizacao de proteina c activada para tratar estados hipercoagulaveis associados com sepsia

Country Status (28)

Country Link
US (7) US6037322A (pt)
EP (2) EP0913156B1 (pt)
JP (2) JP3805981B2 (pt)
KR (1) KR100798174B1 (pt)
CN (1) CN1276726A (pt)
AT (1) ATE292979T1 (pt)
AU (1) AU748417B2 (pt)
BR (1) BR9812965A (pt)
CA (1) CA2306983A1 (pt)
DE (1) DE69829721T2 (pt)
DK (1) DK0913156T3 (pt)
EA (1) EA002496B1 (pt)
ES (1) ES2239382T3 (pt)
HK (1) HK1020529A1 (pt)
HU (2) HUP0001237A3 (pt)
ID (1) ID24901A (pt)
IL (2) IL135712A0 (pt)
MY (1) MY117655A (pt)
NO (1) NO20002005L (pt)
NZ (1) NZ504026A (pt)
PL (1) PL200515B1 (pt)
PT (1) PT913156E (pt)
SI (1) SI0913156T1 (pt)
TR (1) TR200001059T2 (pt)
TW (1) TWI225404B (pt)
UA (1) UA72194C2 (pt)
WO (1) WO1999020293A1 (pt)
ZA (1) ZA989385B (pt)

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AU2002302192B2 (en) * 2001-06-13 2007-08-16 Zz Biotech Llc Treatment and composition for wound healing
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US20030220259A1 (en) * 2001-12-21 2003-11-27 Robbert Benner Treatment of neurological disorders
EA200400548A1 (ru) 2001-10-15 2005-06-30 Чирон Корпорейшн Лечение тяжёлой пневмонии путём введения ингибитора пути тканевого фактора (tfpi)
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US7786084B2 (en) 2001-12-21 2010-08-31 Biotempt B.V. Treatment of burns
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US20030220260A1 (en) * 2001-12-21 2003-11-27 Khan Nisar Ahmed Peptide compositions
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US20030224995A1 (en) * 2001-12-21 2003-12-04 Khan Nisar Ahmed Treatment of burns
JP2005528351A (ja) * 2002-03-08 2005-09-22 イーライ・リリー・アンド・カンパニー 活性化プロテインｃ製剤
TW200407335A (en) * 2002-07-22 2004-05-16 Chugai Pharmaceutical Co Ltd Non-neutralizing antibody to inhibit the inactivation of activated protein C
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GR1005700B (el) * 2006-09-01 2007-10-22 (40%) ����� �������� Τροπος αντιμετωπισης της 1ης φασης του εγκαυματοσσε μη σηπτικους ασθενεις με συνεχη ενδοφλεβια χορηγηση ενεργοποιημενης πρωτεινης-c για 48 ωρες με στοχο τη μειωση της τελικης εγκαυματικης βλαβης καιαυξηση της ταχυτητας επουλωσης κατα τα πρωτα επτα μετεγκαυματικα 24ωρα
EP2078074A4 (en) * 2006-10-31 2011-09-28 Scripps Research Inst DOSAGE SCHEME OF ACTIVATED PROTEIN C AND ITS VARIANTS WITH REDUCED ANTICOAGULANT ACTIVITY
RU2445365C1 (ru) * 2010-11-03 2012-03-20 Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат") Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты)
RU2490722C1 (ru) * 2012-04-24 2013-08-20 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Способ восстановления кровотока в регионе тромбированной вены в эксперименте
ES2676422T3 (es) 2012-07-04 2018-07-19 Zz Biotech Llc Proteína C activada para su uso en el tratamiento de trastornos inflamatorios de la piel
CN106573040B (zh) 2014-04-16 2021-07-06 Zz生物技术有限责任公司 治疗异常皮肤瘢痕形成
CN112292467A (zh) 2018-06-15 2021-01-29 山特维克材料技术公司 双相不锈钢带及其制造方法

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Also Published As

Publication number Publication date
NZ504026A (en) 2002-12-20
US6156734A (en) 2000-12-05
EP0913156B1 (en) 2005-04-13
US6037322A (en) 2000-03-14
US6489296B1 (en) 2002-12-03
BR9812965A (pt) 2001-03-20
EA200000445A1 (ru) 2000-10-30
DE69829721D1 (de) 2005-05-19
EP0913156A1 (en) 1999-05-06
NO20002005L (no) 2000-05-16
HU224901B1 (en) 2006-04-28
IL135712A (en) 2010-12-30
US6268344B1 (en) 2001-07-31
JP2005097313A (ja) 2005-04-14
EP1449537A3 (en) 2005-09-21
HUP0100025A2 (hu) 2001-05-28
US6008199A (en) 1999-12-28
IL135712A0 (en) 2001-05-20
JP2001520199A (ja) 2001-10-30
KR100798174B1 (ko) 2008-01-24
TR200001059T2 (tr) 2000-10-23
KR20010031217A (ko) 2001-04-16
ID24901A (id) 2000-08-31
JP3805981B2 (ja) 2006-08-09
ES2239382T3 (es) 2005-09-16
TWI225404B (en) 2004-12-21
SI0913156T1 (en) 2005-10-31
US6426071B2 (en) 2002-07-30
HUP0100025A3 (en) 2003-08-28
DE69829721T2 (de) 2006-02-09
PL200515B1 (pl) 2009-01-30
MY117655A (en) 2004-07-31
HUP0001237A3 (en) 2002-01-28
ZA989385B (en) 2000-04-14
DK0913156T3 (da) 2005-06-27
HK1020529A1 (en) 2000-05-12
CA2306983A1 (en) 1999-04-29
UA72194C2 (en) 2005-02-15
PL340096A1 (en) 2001-01-15
WO1999020293A1 (en) 1999-04-29
HUP0001237A2 (hu) 2000-08-28
EA002496B1 (ru) 2002-06-27
ATE292979T1 (de) 2005-04-15
EP1449537A2 (en) 2004-08-25
AU748417B2 (en) 2002-06-06
CN1276726A (zh) 2000-12-13
US20010036456A1 (en) 2001-11-01
US6268337B1 (en) 2001-07-31
AU9804098A (en) 1999-05-10
NO20002005D0 (no) 2000-04-17

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