HUP0001237A2 - Módszerek érrendszeri rendellenességek gyógykezeléséhez - Google Patents

Módszerek érrendszeri rendellenességek gyógykezeléséhez

Info

Publication number
HUP0001237A2
HUP0001237A2 HU0001237A HUP0001237A HUP0001237A2 HU P0001237 A2 HUP0001237 A2 HU P0001237A2 HU 0001237 A HU0001237 A HU 0001237A HU P0001237 A HUP0001237 A HU P0001237A HU P0001237 A2 HUP0001237 A2 HU P0001237A2
Authority
HU
Hungary
Prior art keywords
methods
vascular disorders
treating vascular
apc
treatment
Prior art date
Application number
HU0001237A
Other languages
English (en)
Inventor
Brian W. Grinnell
Daniel C. Howey
Charles V. Jackson
Original Assignee
Eli Lilly & Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly & Company filed Critical Eli Lilly & Company
Publication of HUP0001237A2 publication Critical patent/HUP0001237A2/hu
Publication of HUP0001237A3 publication Critical patent/HUP0001237A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Surgery (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Atalálmány tárgyát egy, az érelzáródással és artériástrőmbűsembóliával kapcsőlatős rendellenességekben szenvedő hűmánpáciensek számára kidőlgőzőtt gyógykezelési módszer képezi, melyneksőrán az említett páciensnél aktivált prőtein C 0,01-0,05mg/kg/órásadagja kerül beadásra. Atalálmány tárgyát képezi tővábbá egy egyszeriadagős, 5-20mg aktivált prőtein C-t tartalmazó fiőla, valamint azaktivált prőtein C 0,01-0,05mg/kg/órás dózisban gyógyszerként történőalkalmazása az érelzáródással és artériás trőmbűsembóliávalkapcsőlatős rendellenességek gyógykezelésében. ŕ
HU0001237A 1997-10-20 1998-03-24 Methods for treating vascular disorders HUP0001237A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6254997P 1997-10-20 1997-10-20
US6476597P 1997-11-07 1997-11-07

Publications (2)

Publication Number Publication Date
HUP0001237A2 true HUP0001237A2 (hu) 2000-08-28
HUP0001237A3 HUP0001237A3 (en) 2002-01-28

Family

ID=26742406

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0001237A HUP0001237A3 (en) 1997-10-20 1998-03-24 Methods for treating vascular disorders
HU0100025A HU224901B1 (en) 1997-10-20 1998-10-14 Methods for treating hypercoagulable states or acquired protein c deficiency

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0100025A HU224901B1 (en) 1997-10-20 1998-10-14 Methods for treating hypercoagulable states or acquired protein c deficiency

Country Status (28)

Country Link
US (7) US6037322A (hu)
EP (2) EP0913156B1 (hu)
JP (2) JP3805981B2 (hu)
KR (1) KR100798174B1 (hu)
CN (1) CN1276726A (hu)
AT (1) ATE292979T1 (hu)
AU (1) AU748417B2 (hu)
BR (1) BR9812965A (hu)
CA (1) CA2306983A1 (hu)
DE (1) DE69829721T2 (hu)
DK (1) DK0913156T3 (hu)
EA (1) EA002496B1 (hu)
ES (1) ES2239382T3 (hu)
HK (1) HK1020529A1 (hu)
HU (2) HUP0001237A3 (hu)
ID (1) ID24901A (hu)
IL (2) IL135712A0 (hu)
MY (1) MY117655A (hu)
NO (1) NO20002005L (hu)
NZ (1) NZ504026A (hu)
PL (1) PL200515B1 (hu)
PT (1) PT913156E (hu)
SI (1) SI0913156T1 (hu)
TR (1) TR200001059T2 (hu)
TW (1) TWI225404B (hu)
UA (1) UA72194C2 (hu)
WO (1) WO1999020293A1 (hu)
ZA (1) ZA989385B (hu)

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JP4846799B2 (ja) 2005-07-05 2011-12-28 バイオテンプト ベー．フェー． 腫瘍の治療
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RU2445365C1 (ru) * 2010-11-03 2012-03-20 Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат") Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты)
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Also Published As

Publication number Publication date
IL135712A (en) 2010-12-30
DK0913156T3 (da) 2005-06-27
EA200000445A1 (ru) 2000-10-30
JP2005097313A (ja) 2005-04-14
PL340096A1 (en) 2001-01-15
EP0913156A1 (en) 1999-05-06
WO1999020293A1 (en) 1999-04-29
US6156734A (en) 2000-12-05
IL135712A0 (en) 2001-05-20
SI0913156T1 (en) 2005-10-31
EP0913156B1 (en) 2005-04-13
KR20010031217A (ko) 2001-04-16
US6489296B1 (en) 2002-12-03
KR100798174B1 (ko) 2008-01-24
ES2239382T3 (es) 2005-09-16
ATE292979T1 (de) 2005-04-15
CA2306983A1 (en) 1999-04-29
US6008199A (en) 1999-12-28
PL200515B1 (pl) 2009-01-30
DE69829721D1 (de) 2005-05-19
CN1276726A (zh) 2000-12-13
HUP0100025A3 (en) 2003-08-28
PT913156E (pt) 2005-08-31
HU224901B1 (en) 2006-04-28
DE69829721T2 (de) 2006-02-09
JP2001520199A (ja) 2001-10-30
EP1449537A2 (en) 2004-08-25
EA002496B1 (ru) 2002-06-27
JP3805981B2 (ja) 2006-08-09
US20010036456A1 (en) 2001-11-01
US6268337B1 (en) 2001-07-31
BR9812965A (pt) 2001-03-20
MY117655A (en) 2004-07-31
HUP0100025A2 (hu) 2001-05-28
AU9804098A (en) 1999-05-10
UA72194C2 (en) 2005-02-15
US6268344B1 (en) 2001-07-31
TWI225404B (en) 2004-12-21
HK1020529A1 (en) 2000-05-12
TR200001059T2 (tr) 2000-10-23
ID24901A (id) 2000-08-31
ZA989385B (en) 2000-04-14
AU748417B2 (en) 2002-06-06
EP1449537A3 (en) 2005-09-21
NO20002005L (no) 2000-05-16
US6037322A (en) 2000-03-14
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US6426071B2 (en) 2002-07-30
NO20002005D0 (no) 2000-04-17

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