PT712862E - Acilacao selectiva de grupos epsilon-amino em ensulina - Google Patents

Acilacao selectiva de grupos epsilon-amino em ensulina

Info

Publication number
PT712862E
PT712862E PT95308167T PT95308167T PT712862E PT 712862 E PT712862 E PT 712862E PT 95308167 T PT95308167 T PT 95308167T PT 95308167 T PT95308167 T PT 95308167T PT 712862 E PT712862 E PT 712862E
Authority
PT
Portugal
Prior art keywords
ensulina
acilacation
epsilon
selective
amino groups
Prior art date
Application number
PT95308167T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT712862E publication Critical patent/PT712862E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT95308167T 1994-11-17 1995-11-14 Acilacao selectiva de grupos epsilon-amino em ensulina PT712862E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
PT712862E true PT712862E (pt) 2006-08-31

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95308167T PT712862E (pt) 1994-11-17 1995-11-14 Acilacao selectiva de grupos epsilon-amino em ensulina

Country Status (27)

Country Link
US (2) US5646242A (OSRAM)
EP (2) EP1227107A1 (OSRAM)
JP (1) JP4312828B2 (OSRAM)
CN (1) CN1171742A (OSRAM)
AR (1) AR003915A1 (OSRAM)
AT (1) ATE328902T1 (OSRAM)
AU (2) AU691066B2 (OSRAM)
BR (1) BR9509652A (OSRAM)
CA (1) CA2205061A1 (OSRAM)
CO (1) CO4520285A1 (OSRAM)
CZ (1) CZ287731B6 (OSRAM)
DE (1) DE69535031T2 (OSRAM)
DK (1) DK0712862T3 (OSRAM)
ES (1) ES2264124T3 (OSRAM)
HU (2) HU217585B (OSRAM)
IL (1) IL115972A (OSRAM)
IN (1) IN179820B (OSRAM)
NO (1) NO972185D0 (OSRAM)
NZ (1) NZ297256A (OSRAM)
PL (1) PL320556A1 (OSRAM)
PT (1) PT712862E (OSRAM)
RU (1) RU2155773C2 (OSRAM)
SI (1) SI0712862T1 (OSRAM)
TR (1) TR199501421A2 (OSRAM)
WO (1) WO1996015803A1 (OSRAM)
YU (1) YU71495A (OSRAM)
ZA (1) ZA959680B (OSRAM)

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US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
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US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
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US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
US7595172B2 (en) 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
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US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
PT1430082E (pt) 2001-09-07 2010-01-15 Biocon Ltd Métodos de síntese de conjugados de polipéptido de insulina-oligómero, e conjugados de polipéptido de pró-insulina-oligómero e método de síntese dos mesmos
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
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CN105636979B (zh) 2013-10-07 2020-01-10 诺和诺德股份有限公司 胰岛素类似物的新衍生物
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CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
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Also Published As

Publication number Publication date
AU4237296A (en) 1996-06-17
HU9903007D0 (en) 1999-11-29
MX9703506A (es) 1997-07-31
JPH10509176A (ja) 1998-09-08
IN179820B (OSRAM) 1997-12-13
IL115972A0 (en) 1996-01-31
CN1171742A (zh) 1998-01-28
USRE37971E1 (en) 2003-01-28
NO972185L (no) 1997-05-13
AR003915A1 (es) 1998-09-30
US5646242A (en) 1997-07-08
EP0712862A3 (en) 1998-03-04
ES2264124T3 (es) 2006-12-16
TR199501421A2 (tr) 1996-06-21
DE69535031T2 (de) 2006-12-28
DE69535031D1 (de) 2006-07-20
ZA959680B (en) 1997-05-14
EP0712862A2 (en) 1996-05-22
JP4312828B2 (ja) 2009-08-12
ATE328902T1 (de) 2006-06-15
WO1996015803A1 (en) 1996-05-30
AU691066B2 (en) 1998-05-07
CZ145697A3 (en) 1997-12-17
AU7885498A (en) 1998-11-05
EP0712862B1 (en) 2006-06-07
IL115972A (en) 2000-09-28
CA2205061A1 (en) 1996-05-30
CO4520285A1 (es) 1997-10-15
YU71495A (sh) 1998-09-18
NZ297256A (en) 2000-01-28
SI0712862T1 (sl) 2006-10-31
RU2155773C2 (ru) 2000-09-10
HUT77737A (hu) 1998-07-28
PL320556A1 (en) 1997-10-13
HU217585B (hu) 2000-02-28
CZ287731B6 (en) 2001-01-17
NO972185D0 (no) 1997-05-13
EP1227107A1 (en) 2002-07-31
HK1014007A1 (en) 1999-09-17
AU720820B2 (en) 2000-06-15
DK0712862T3 (da) 2006-09-25
BR9509652A (pt) 1997-09-16

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